SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q2v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 LEU A  61
THR A  11
LEU A  34
GLY A  36
 None
 0.95A 1gtiA-2q2vA:
undetectable		 1gtiA-2q2vA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
putida) 		4 / 8 LEU A 112
VAL A 115
VAL A 165
VAL A 166
 None
 0.74A 1iwiA-2q2vA:
undetectable		 1iwiA-2q2vA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 ILE A 135
ILE A 180
THR A 176
 None
 0.37A 1rg7A-2q2vA:
undetectable		 1rg7A-2q2vA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 LEU A  61
ASN A  35
LEU A   9
PHE A  71
 None
 1.40A 1rukH-2q2vA:
undetectable
1rukL-2q2vA:
undetectable		 1rukH-2q2vA:
22.26
1rukL-2q2vA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
putida) 		4 / 8 LEU A 112
VAL A 115
VAL A 165
VAL A 166
 None
 0.79A 1t86A-2q2vA:
undetectable		 1t86A-2q2vA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
putida) 		5 / 9 GLY A  20
ILE A 180
THR A 163
VAL A  85
VAL A 115
 None
 1.07A 2nnhB-2q2vA:
undetectable		 2nnhB-2q2vA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 LEU A  70
ALA A 114
LEU A 110
ALA A  88
 None
 0.99A 2vcvB-2q2vA:
undetectable		 2vcvB-2q2vA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
putida) 		4 / 8 GLY A 142
ILE A 135
VAL A 166
SER A 139
 None
 0.95A 2yoeB-2q2vA:
undetectable
2yoeC-2q2vA:
undetectable		 2yoeB-2q2vA:
22.05
2yoeC-2q2vA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 LEU A 112
VAL A 115
VAL A 165
VAL A 166
 None
 0.80A 2z97A-2q2vA:
undetectable		 2z97A-2q2vA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
putida) 		4 / 8 LEU A 112
VAL A 115
VAL A 165
VAL A 166
 None
 0.77A 2zujA-2q2vA:
undetectable		 2zujA-2q2vA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
putida) 		5 / 9 LEU A 232
VAL A  85
ILE A 135
ILE A  83
GLY A 239
 None
 1.04A 4kukA-2q2vA:
undetectable		 4kukA-2q2vA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 ARG A 133
ILE A 137
ALA A 138
ALA A 245
GLY A 167
 None
 1.11A 5veuA-2q2vA:
undetectable		 5veuA-2q2vA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 227
ILE A  17
GLY A  18
ILE A 180
ILE A 137
 None
 1.06A 6emuB-2q2vA:
undetectable		 6emuB-2q2vA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 227
ILE A  17
GLY A  18
ILE A 180
ILE A 137
 None
 1.06A 6emuC-2q2vA:
3.2		 6emuC-2q2vA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
putida) 		4 / 8 GLY A 145
GLY A 183
SER A 139
ALA A 138
 None
 0.76A 6hu9H-2q2vA:
undetectable
6hu9e-2q2vA:
undetectable		 6hu9H-2q2vA:
16.06
6hu9e-2q2vA:
21.61