SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q3f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1F5L_A_AMRA301_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	2q3f	RAS-RELATED GTP-BINDING PROTEIN D (Homo sapiens)	4 / 8	SER A 54 SER A 57 GLY A 101 GLY A 50	GNP A 401 (-3.5A) MG A 301 ( 2.1A) GNP A 401 (-3.2A) None	0.69A	1f5lA-2q3fA: undetectable	1f5lA-2q3fA: 19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HSH_C_MK1C402_2 (HIV-II PROTEASE)	2q3f	RAS-RELATED GTP-BINDING PROTEIN D (Homo sapiens)	5 / 8	ALA A 121 GLY A 118 ILE A 115 ILE A 96 ILE A 46	None	1.22A	1hshD-2q3fA: undetectable	1hshD-2q3fA: 19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2KCE_A_D16A566_2 (THYMIDYLATE SYNTHASE)	2q3f	RAS-RELATED GTP-BINDING PROTEIN D (Homo sapiens)	3 / 3	HIS A 178 ILE A 159 LEU A 139	None	0.72A	2kceA-2q3fA: undetectable	2kceA-2q3fA: 21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OTV_A_NCAA1301_0 (CATIONIC TRYPSIN)	2q3f	RAS-RELATED GTP-BINDING PROTEIN D (Homo sapiens)	4 / 6	SER A 54 SER A 57 GLY A 101 GLY A 50	GNP A 401 (-3.5A) MG A 301 ( 2.1A) GNP A 401 (-3.2A) None	0.76A	2otvA-2q3fA: undetectable	2otvA-2q3fA: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	2q3f	RAS-RELATED GTP-BINDING PROTEIN D (Homo sapiens)	4 / 8	SER A 54 SER A 57 GLY A 101 GLY A 50	GNP A 401 (-3.5A) MG A 301 ( 2.1A) GNP A 401 (-3.2A) None	0.75A	2vinA-2q3fA: undetectable	2vinA-2q3fA: 19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RXF_A_4APA9_1 (CATIONIC TRYPSIN)	2q3f	RAS-RELATED GTP-BINDING PROTEIN D (Homo sapiens)	4 / 6	SER A 54 SER A 57 GLY A 101 GLY A 50	GNP A 401 (-3.5A) MG A 301 ( 2.1A) GNP A 401 (-3.2A) None	0.68A	3rxfA-2q3fA: undetectable	3rxfA-2q3fA: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WGQ_A_ESTA601_1 (ESTROGEN RECEPTOR)	2q3f	RAS-RELATED GTP-BINDING PROTEIN D (Homo sapiens)	5 / 9	ALA A 135 GLU A 134 LEU A 51 GLY A 55 HIS A 160	None None None GNP A 401 (-3.3A) GNP A 401 (-3.5A)	1.49A	5wgqA-2q3fA: undetectable	5wgqA-2q3fA: 16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CK2_C_IPHC101_0 (INSULIN A CHAIN INSULIN B CHAIN)	2q3f	RAS-RELATED GTP-BINDING PROTEIN D (Homo sapiens)	4 / 4	ILE A 159 LEU A 139 HIS A 178 ALA A 181	None	1.05A	6ck2C-2q3fA: undetectable 6ck2D-2q3fA: undetectable	6ck2C-2q3fA: 6.63 6ck2D-2q3fA: 14.05

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1F5L_A_AMRA301_1","UROKINASE-TYPE PLASMINOGEN ACTIVATOR","2q3f","RAS-RELATED GTP-BINDING PROTEIN D","Homo sapiens",4,"SER A  54;SER A  57;GLY A 101;GLY A  50","GNP A 401 (-3.5A); MG A 301 ( 2.1A);GNP A 401 (-3.2A);None","0.69A","1f5lA-2q3fA:undetectable","1f5lA-2q3fA:19.77"],["1HSH_C_MK1C402_2","HIV-II PROTEASE;HIV-II PROTEASE","2q3f","RAS-RELATED GTP-BINDING PROTEIN D","Homo sapiens",5,"ALA A 121;GLY A 118;ILE A 115;ILE A  96;ILE A  46","None","1.22A","1hshD-2q3fA:undetectable","1hshD-2q3fA:19.21"],["2KCE_A_D16A566_2","THYMIDYLATE SYNTHASE","2q3f","RAS-RELATED GTP-BINDING PROTEIN D","Homo sapiens",3,"HIS A 178;ILE A 159;LEU A 139","None","0.72A","2kceA-2q3fA:undetectable","2kceA-2q3fA:21.62"],["2OTV_A_NCAA1301_0","CATIONIC TRYPSIN","2q3f","RAS-RELATED GTP-BINDING PROTEIN D","Homo sapiens",4,"SER A  54;SER A  57;GLY A 101;GLY A  50","GNP A 401 (-3.5A); MG A 301 ( 2.1A);GNP A 401 (-3.2A);None","0.76A","2otvA-2q3fA:undetectable","2otvA-2q3fA:21.05"],["2VIN_A_505A1247_1","UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B","2q3f","RAS-RELATED GTP-BINDING PROTEIN D","Homo sapiens",4,"SER A  54;SER A  57;GLY A 101;GLY A  50","GNP A 401 (-3.5A); MG A 301 ( 2.1A);GNP A 401 (-3.2A);None","0.75A","2vinA-2q3fA:undetectable","2vinA-2q3fA:19.77"],["3RXF_A_4APA9_1","CATIONIC TRYPSIN","2q3f","RAS-RELATED GTP-BINDING PROTEIN D","Homo sapiens",4,"SER A  54;SER A  57;GLY A 101;GLY A  50","GNP A 401 (-3.5A); MG A 301 ( 2.1A);GNP A 401 (-3.2A);None","0.68A","3rxfA-2q3fA:undetectable","3rxfA-2q3fA:21.05"],["5WGQ_A_ESTA601_1","ESTROGEN RECEPTOR","2q3f","RAS-RELATED GTP-BINDING PROTEIN D","Homo sapiens",5,"ALA A 135;GLU A 134;LEU A  51;GLY A  55;HIS A 160","None;None;None;GNP A 401 (-3.3A);GNP A 401 (-3.5A)","1.49A","5wgqA-2q3fA:undetectable","5wgqA-2q3fA:16.94"],["6CK2_C_IPHC101_0","INSULIN A CHAIN;INSULIN B CHAIN","2q3f","RAS-RELATED GTP-BINDING PROTEIN D","Homo sapiens",4,"ILE A 159;LEU A 139;HIS A 178;ALA A 181","None","1.05A","6ck2C-2q3fA:undetectable;6ck2D-2q3fA:undetectable","6ck2C-2q3fA:6.63;6ck2D-2q3fA:14.05"]]