SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q3r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H60_A_STRA500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		5 / 9 THR A  33
TYR A  74
HIS A 183
TYR A 188
TYR A 354
 FMN  A 373 (-3.8A)
None
FMN  A 373 (-3.8A)
None
FMN  A 373 (-3.8A)
 0.62A 1h60A-2q3rA:
50.4		 1h60A-2q3rA:
43.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ABA_A_STRA1500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		5 / 9 THR A  33
TYR A  74
HIS A 183
TYR A 188
TYR A 354
 FMN  A 373 (-3.8A)
None
FMN  A 373 (-3.8A)
None
FMN  A 373 (-3.8A)
 0.61A 2abaA-2q3rA:
50.6		 2abaA-2q3rA:
43.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		4 / 7 PHE A 103
TYR A 362
TRP A  89
GLU A  63
 None
 1.38A 2aowA-2q3rA:
undetectable		 2aowA-2q3rA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		3 / 3 ASP A 321
VAL A  28
PRO A  31
 None
None
FMN  A 373 (-4.2A)
 0.68A 2avvA-2q3rA:
undetectable		 2avvA-2q3rA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		5 / 11 ILE A 102
GLY A 233
LEU A 322
PHE A  59
TYR A  16
 None
 1.04A 2azyA-2q3rA:
undetectable		 2azyA-2q3rA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		4 / 8 ILE A 161
ARG A 151
LEU A 153
GLU A 157
 None
 0.64A 2cdqA-2q3rA:
undetectable		 2cdqA-2q3rA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		3 / 3 THR A  70
PRO A 125
PRO A 120
 None
 0.88A 2d55C-2q3rA:
undetectable		 2d55C-2q3rA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		4 / 5 ALA A 185
ALA A 303
ALA A 324
GLN A 106
 None
FMN  A 373 (-3.5A)
None
FMN  A 373 (-2.8A)
 0.89A 2nyrB-2q3rA:
undetectable		 2nyrB-2q3rA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		4 / 8 TYR A 188
TYR A 242
ILE A 272
SER A 245
 None
 1.05A 2xz5B-2q3rA:
undetectable
2xz5E-2q3rA:
undetectable		 2xz5B-2q3rA:
19.89
2xz5E-2q3rA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		4 / 7 ILE A 272
SER A 245
TYR A 188
TYR A 242
 None
 1.04A 2xz5D-2q3rA:
undetectable
2xz5E-2q3rA:
undetectable		 2xz5D-2q3rA:
19.89
2xz5E-2q3rA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		3 / 3 LEU A 153
VAL A 198
ARG A 201
 None
 0.60A 3b0wB-2q3rA:
undetectable		 3b0wB-2q3rA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		5 / 12 ILE A 190
MET A 257
LEU A 217
ILE A 266
ILE A 182
 None
 1.12A 3ql3A-2q3rA:
undetectable		 3ql3A-2q3rA:
18.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		5 / 9 THR A  33
ALA A  64
HIS A 183
TYR A 188
TYR A 354
 FMN  A 373 (-3.8A)
FMN  A 373 (-3.3A)
FMN  A 373 (-3.8A)
None
FMN  A 373 (-3.8A)
 0.40A 3upwA-2q3rA:
46.2		 3upwA-2q3rA:
35.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1003_1
(HEMOLYTIC LECTIN
CEL-III)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		4 / 4 ASP A 203
GLU A 156
GLY A 154
TYR A 205
 None
 1.43A 3w9tA-2q3rA:
0.0		 3w9tA-2q3rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB507_1
(HEMOLYTIC LECTIN
CEL-III)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		4 / 4 ASP A 203
GLU A 156
GLY A 154
TYR A 205
 None
 1.42A 3w9tB-2q3rA:
0.0		 3w9tB-2q3rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		4 / 5 ASP A 203
GLU A 156
GLY A 154
TYR A 205
 None
 1.42A 3w9tD-2q3rA:
undetectable		 3w9tD-2q3rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE503_1
(HEMOLYTIC LECTIN
CEL-III)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		4 / 4 ASP A 203
GLU A 156
GLY A 154
TYR A 205
 None
 1.43A 3w9tE-2q3rA:
0.0		 3w9tE-2q3rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF502_1
(HEMOLYTIC LECTIN
CEL-III)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		4 / 4 ASP A 203
GLU A 156
GLY A 154
TYR A 205
 None
 1.43A 3w9tF-2q3rA:
0.0		 3w9tF-2q3rA:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		5 / 7 THR A  33
HIS A 183
ASN A 186
TYR A 188
TYR A 354
 FMN  A 373 (-3.8A)
FMN  A 373 (-3.8A)
FMN  A 373 ( 4.9A)
None
FMN  A 373 (-3.8A)
 0.61A 4a3uA-2q3rA:
49.6		 4a3uA-2q3rA:
40.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		5 / 7 THR A  33
HIS A 183
ASN A 186
TYR A 188
TYR A 354
 FMN  A 373 (-3.8A)
FMN  A 373 (-3.8A)
FMN  A 373 ( 4.9A)
None
FMN  A 373 (-3.8A)
 0.65A 4a3uB-2q3rA:
49.8		 4a3uB-2q3rA:
40.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		4 / 7 THR A  33
HIS A 183
ASN A 186
TYR A 188
 FMN  A 373 (-3.8A)
FMN  A 373 (-3.8A)
FMN  A 373 ( 4.9A)
None
 0.50A 4awuA-2q3rA:
50.4		 4awuA-2q3rA:
40.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		3 / 3 ASN A 199
LEU A 253
PHE A 215
 None
 0.76A 4dajB-2q3rA:
undetectable		 4dajB-2q3rA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		5 / 6 THR A  33
TYR A  74
HIS A 183
TYR A 188
TYR A 354
 FMN  A 373 (-3.8A)
None
FMN  A 373 (-3.8A)
None
FMN  A 373 (-3.8A)
 1.00A 4df2A-2q3rA:
46.1		 4df2A-2q3rA:
35.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		4 / 6 PRO A  31
ARG A 235
GLY A 184
ALA A  64
 FMN  A 373 (-4.2A)
FMN  A 373 (-2.7A)
None
FMN  A 373 (-3.3A)
 0.97A 4g0uA-2q3rA:
undetectable		 4g0uA-2q3rA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 209
SER A 260
LEU A 261
TYR A 256
ASP A 191
 None
 1.46A 4j7xJ-2q3rA:
3.6		 4j7xJ-2q3rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		4 / 5 PRO A  15
LEU A  60
TYR A 325
PHE A 306
 None
 1.37A 5igjA-2q3rA:
undetectable		 5igjA-2q3rA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		5 / 12 ARG A  26
LEU A 322
GLY A 101
HIS A  97
GLY A  57
 None
 1.12A 5l6eA-2q3rA:
undetectable		 5l6eA-2q3rA:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		5 / 8 THR A  33
HIS A 183
ASN A 186
TYR A 188
TYR A 354
 FMN  A 373 (-3.8A)
FMN  A 373 (-3.8A)
FMN  A 373 ( 4.9A)
None
FMN  A 373 (-3.8A)
 0.74A 5v4vA-2q3rA:
47.5		 5v4vA-2q3rA:
39.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		5 / 8 THR A  33
HIS A 183
ASN A 186
TYR A 188
TYR A 354
 FMN  A 373 (-3.8A)
FMN  A 373 (-3.8A)
FMN  A 373 ( 4.9A)
None
FMN  A 373 (-3.8A)
 0.73A 5v4vB-2q3rA:
47.6		 5v4vB-2q3rA:
39.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1
(Arabidopsis
thaliana) 		3 / 3 GLY A 206
ASN A 199
ARG A 152
 None
 0.78A 5w7bD-2q3rA:
undetectable		 5w7bD-2q3rA:
11.89