SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2q3x REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1
(Rattus
norvegicus) 		4 / 7 PHE A1533
LEU A1504
LEU A1566
LEU A1542
 None
 0.88A 3bgdB-2q3xA:
undetectable		 3bgdB-2q3xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 2q3x REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1
(Rattus
norvegicus) 		3 / 3 GLU A1479
GLY A1468
SER A1530
 None
 0.66A 4b53B-2q3xA:
3.7		 4b53B-2q3xA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2q3x REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1
(Rattus
norvegicus) 		4 / 8 LEU A1571
ILE A1564
VAL A1544
GLY A1468
 None
 0.69A 4eq4B-2q3xA:
undetectable		 4eq4B-2q3xA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 2q3x REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1
(Rattus
norvegicus) 		5 / 12 LEU A1531
VAL A1502
ILE A1465
VAL A1575
LEU A1569
 None
 1.03A 4y0pA-2q3xA:
undetectable		 4y0pA-2q3xA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 2q3x REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1
(Rattus
norvegicus) 		3 / 3 CYH A1557
LYS A1556
HIS A1555
 None
SO4  A 201 ( 2.7A)
None
 1.06A 5js5A-2q3xA:
undetectable		 5js5A-2q3xA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 2q3x REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1
(Rattus
norvegicus) 		4 / 5 TYR A1527
GLN A1529
GLY A1577
ILE A1465
 None
 1.34A 6debB-2q3xA:
undetectable		 6debB-2q3xA:
19.53