SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		4 / 7 GLU A 329
SER A 365
PHE A 392
ALA A 395
 None
 1.00A 1fo4B-2q3zA:
1.7		 1fo4B-2q3zA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 4 VAL A 393
TRP A 332
TRP A 337
 None
 1.37A 1gmkC-2q3zA:
undetectable
1gmkD-2q3zA:
undetectable		 1gmkC-2q3zA:
3.47
1gmkD-2q3zA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		5 / 11 LEU A 197
GLY A 224
VAL A 338
LEU A 357
LEU A 291
 None
 1.33A 1mx1B-2q3zA:
undetectable		 1mx1B-2q3zA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 ALA A 281
VAL A 283
TRP A 180
 None
 0.87A 1nrmA-2q3zA:
undetectable		 1nrmA-2q3zA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 ALA A 281
VAL A 283
TRP A 180
 None
 0.87A 1nrmB-2q3zA:
undetectable		 1nrmB-2q3zA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 ALA A 281
VAL A 283
TRP A 180
 None
 0.83A 1nt5A-2q3zA:
undetectable		 1nt5A-2q3zA:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 ALA A 281
VAL A 283
TRP A 180
 None
 0.83A 1nt5B-2q3zA:
undetectable		 1nt5B-2q3zA:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 GLN A  37
HIS A  22
ARG A  19
 None
 1.07A 1zlqA-2q3zA:
0.8		 1zlqA-2q3zA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 LEU A 532
TRP A 404
TYR A 503
 None
 0.80A 3aicA-2q3zA:
undetectable		 3aicA-2q3zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 LEU A 532
TRP A 404
TYR A 503
 None
 0.84A 3aicB-2q3zA:
undetectable		 3aicB-2q3zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 LEU A 532
TRP A 404
TYR A 503
 None
 0.85A 3aicE-2q3zA:
undetectable		 3aicE-2q3zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 LEU A 532
TRP A 404
TYR A 503
 None
 0.84A 3aicF-2q3zA:
undetectable		 3aicF-2q3zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 LEU A 532
TRP A 404
TYR A 503
 None
 0.83A 3aicG-2q3zA:
undetectable		 3aicG-2q3zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 LEU A 532
TRP A 404
TYR A 503
 None
 0.85A 3aicH-2q3zA:
undetectable		 3aicH-2q3zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		4 / 7 GLY A 183
ASP A 259
TRP A 254
ARG A 263
 None
 0.80A 3arrA-2q3zA:
3.2		 3arrA-2q3zA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		4 / 7 GLY A 183
ASP A 259
TRP A 254
ARG A 263
 None
 0.87A 3aruA-2q3zA:
4.5		 3aruA-2q3zA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		4 / 8 GLU A 329
SER A 365
PHE A 392
ALA A 395
 None
 1.01A 3ax9B-2q3zA:
undetectable		 3ax9B-2q3zA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		4 / 6 THR A 286
VAL A 287
LEU A 261
CYH A 193
 None
 1.17A 3b6rB-2q3zA:
undetectable		 3b6rB-2q3zA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		4 / 4 VAL A 160
ARG A  35
ILE A 136
THR A 295
 None
 1.26A 3cl9A-2q3zA:
undetectable		 3cl9A-2q3zA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		5 / 12 GLN A 270
VAL A 228
VAL A 283
LEU A 261
ILE A 192
 None
 0.99A 3gwxB-2q3zA:
undetectable		 3gwxB-2q3zA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 LEU A 261
TRP A 264
GLY A 235
 None
 0.53A 3l35A-2q3zA:
undetectable
3l35H-2q3zA:
undetectable		 3l35A-2q3zA:
5.21
3l35H-2q3zA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 LEU A 261
TRP A 264
GLY A 235
 None
 0.46A 3l35B-2q3zA:
undetectable
3l35K-2q3zA:
undetectable		 3l35B-2q3zA:
5.21
3l35K-2q3zA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 ASP A 389
GLY A 367
TYR A 388
 None
SO4  A 688 (-3.1A)
None
 0.68A 3w9tC-2q3zA:
undetectable		 3w9tC-2q3zA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 ASP A 389
GLY A 367
TYR A 388
 None
SO4  A 688 (-3.1A)
None
 0.68A 3w9tG-2q3zA:
undetectable		 3w9tG-2q3zA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		4 / 8 SER A 419
GLU A 314
ILE A 313
ASN A 417
 None
 0.98A 4d33A-2q3zA:
undetectable		 4d33A-2q3zA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		4 / 7 SER A 419
GLU A 314
ILE A 313
ASN A 417
 None
 1.00A 4d33B-2q3zA:
undetectable		 4d33B-2q3zA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		4 / 8 SER A 419
GLU A 314
ILE A 313
ASN A 417
 None
 1.01A 4d39A-2q3zA:
undetectable		 4d39A-2q3zA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		4 / 7 SER A 419
GLU A 314
ILE A 313
ASN A 417
 None
 0.98A 4d39B-2q3zA:
undetectable		 4d39B-2q3zA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		5 / 12 LEU A 534
LEU A 544
LYS A 540
MET A 475
LEU A 507
 None
 1.21A 4x61A-2q3zA:
undetectable		 4x61A-2q3zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		4 / 6 ASN A 300
ASP A 358
THR A 442
THR A 440
 None
 1.11A 4yoaA-2q3zA:
undetectable		 4yoaA-2q3zA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		5 / 10 LEU A 132
LEU A  43
LEU A 102
LEU A 104
LEU A 117
 None
 1.04A 4z91A-2q3zA:
3.2
4z91B-2q3zA:
3.2
4z91C-2q3zA:
3.3
4z91D-2q3zA:
3.1
4z91E-2q3zA:
3.1		 4z91A-2q3zA:
18.70
4z91B-2q3zA:
18.70
4z91C-2q3zA:
18.70
4z91D-2q3zA:
18.70
4z91E-2q3zA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		4 / 5 LEU A 567
ALA A 565
LEU A 576
VAL A 563
 None
 1.12A 5cr1A-2q3zA:
undetectable		 5cr1A-2q3zA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		4 / 8 ARG A 289
ILE A 112
ASP A 191
LEU A 190
 None
 0.84A 5nooD-2q3zA:
undetectable		 5nooD-2q3zA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		4 / 8 LEU A 311
VAL A 563
ARG A 564
ILE A 477
 None
 0.99A 5v0vA-2q3zA:
undetectable		 5v0vA-2q3zA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 GLY A 353
THR A 162
PRO A 294
 None
 0.58A 5v5zA-2q3zA:
undetectable		 5v5zA-2q3zA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		5 / 9 VAL A 220
GLY A 292
LEU A 138
VAL A 287
CYH A 290
 None
 1.05A 6czmD-2q3zA:
undetectable
6czmE-2q3zA:
undetectable		 6czmD-2q3zA:
21.12
6czmE-2q3zA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		5 / 10 VAL A 220
GLY A 292
LEU A 138
VAL A 287
CYH A 290
 None
 1.04A 6czmE-2q3zA:
undetectable
6czmF-2q3zA:
undetectable		 6czmE-2q3zA:
21.12
6czmF-2q3zA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2q3z TRANSGLUTAMINASE 2
(Homo
sapiens) 		3 / 3 VAL A  54
ALA A   2
GLN A  51
 None
 0.70A 6gb9A-2q3zA:
undetectable		 6gb9A-2q3zA:
21.34