SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		3 / 3 GLU A 227
HIS A 224
ASP A 114
 None
 0.81A 1i9gA-2q49A:
3.4		 1i9gA-2q49A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		5 / 9 LEU A 352
VAL A 329
TYR A 305
GLY A 302
LEU A 353
 None
 1.33A 1ikvA-2q49A:
undetectable		 1ikvA-2q49A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 6 THR A 297
ASN A 327
LEU A 328
ASP A 326
 None
 0.86A 1mxdA-2q49A:
undetectable		 1mxdA-2q49A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 8 ARG A 116
THR A  28
GLY A 334
ALA A 336
 None
 0.87A 2a1hA-2q49A:
undetectable
2a1hB-2q49A:
undetectable		 2a1hA-2q49A:
21.78
2a1hB-2q49A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		5 / 11 LEU A  36
ILE A  32
VAL A 109
CYH A  89
LEU A 340
 None
 1.41A 2bxeA-2q49A:
undetectable		 2bxeA-2q49A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 4 GLN A 169
GLU A 229
ILE A 228
PRO A 165
 None
 1.44A 2fcnA-2q49A:
undetectable		 2fcnA-2q49A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 TYR A 217
TYR A 127
GLU A 227
GLY A 162
 None
 1.27A 2ha4B-2q49A:
undetectable		 2ha4B-2q49A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 PHE A  42
GLY A 345
GLY A 334
LEU A 337
LEU A  35
 None
 1.06A 2hw2A-2q49A:
undetectable		 2hw2A-2q49A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 6 LEU A  72
MET A  57
LEU A  69
MET A  47
 None
 1.12A 2kuhA-2q49A:
undetectable		 2kuhA-2q49A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMN_B_IPHB401_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 4 PRO A 347
HIS A  41
PRO A  40
TYR A 346
 None
 1.42A 2omnA-2q49A:
0.3
2omnB-2q49A:
1.0		 2omnA-2q49A:
20.90
2omnB-2q49A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		5 / 6 LEU A 272
VAL A 310
ILE A 321
MET A 263
ILE A 181
 None
 1.28A 2piwA-2q49A:
undetectable		 2piwA-2q49A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_1
(PHOSPHOLIPASE A2)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		5 / 10 VAL A 329
GLU A  31
GLY A 331
THR A 145
ARG A  34
 None
 1.29A 3bjwD-2q49A:
0.0		 3bjwD-2q49A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 5 GLU A 348
LEU A 352
GLN A 335
GLY A 334
 None
 1.31A 3pp1A-2q49A:
0.8		 3pp1A-2q49A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		3 / 3 GLN A  96
GLU A  97
LYS A 132
 None
 1.16A 3su9A-2q49A:
undetectable		 3su9A-2q49A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 HIS A  41
MET A 343
GLY A 345
ALA A 155
ASN A 341
 None
 1.16A 3tm4A-2q49A:
3.2		 3tm4A-2q49A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 HIS A  41
MET A 343
GLY A 345
ALA A 155
ASN A 341
 None
 1.17A 3tm4B-2q49A:
3.1		 3tm4B-2q49A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 ILE A 228
ILE A 259
GLU A 184
LEU A 176
 None
 0.82A 3ua5B-2q49A:
undetectable		 3ua5B-2q49A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 ILE A 321
VAL A 240
ILE A 186
GLU A 184
ARG A 318
 None
 1.10A 4i41A-2q49A:
undetectable		 4i41A-2q49A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 5 LEU A 172
PRO A 171
LEU A 175
ILE A 181
 None
 1.07A 4klrA-2q49A:
2.0		 4klrA-2q49A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 ALA A  24
THR A  95
ILE A  98
LEU A 102
PRO A 103
 None
 1.02A 4p3qA-2q49A:
undetectable		 4p3qA-2q49A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 LEU A  21
PHE A  61
VAL A  33
THR A  28
GLY A 196
 None
 1.32A 4q15A-2q49A:
2.4		 4q15A-2q49A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 PHE A  61
GLU A  58
ARG A 199
VAL A  33
 None
 1.49A 5adaA-2q49A:
undetectable
5adaB-2q49A:
undetectable		 5adaA-2q49A:
22.97
5adaB-2q49A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		3 / 3 TYR A  27
TYR A 217
SER A 192
 None
 0.77A 5iktB-2q49A:
undetectable		 5iktB-2q49A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 6 PHE A  61
GLU A  58
ARG A 199
VAL A  33
 None
 1.48A 5unvA-2q49A:
undetectable
5unvB-2q49A:
undetectable		 5unvA-2q49A:
22.97
5unvB-2q49A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 ARG A 199
VAL A  33
PHE A  61
GLU A  58
 None
 1.49A 5unyA-2q49A:
undetectable
5unyB-2q49A:
undetectable		 5unyA-2q49A:
22.97
5unyB-2q49A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 PHE A  61
GLU A  58
ARG A 199
VAL A  33
 None
 1.49A 5unzA-2q49A:
undetectable
5unzB-2q49A:
undetectable		 5unzA-2q49A:
22.97
5unzB-2q49A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 PHE A  61
GLU A  58
ARG A 199
VAL A  33
 None
 1.48A 5uo0A-2q49A:
undetectable
5uo0B-2q49A:
undetectable		 5uo0A-2q49A:
22.97
5uo0B-2q49A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 PHE A  61
GLU A  58
ARG A 199
VAL A  33
 None
 1.49A 5uo3A-2q49A:
undetectable
5uo3B-2q49A:
undetectable		 5uo3A-2q49A:
21.69
5uo3B-2q49A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 PHE A  61
GLU A  58
ARG A 199
VAL A  33
 None
 1.50A 5vusA-2q49A:
undetectable
5vusB-2q49A:
undetectable		 5vusA-2q49A:
22.97
5vusB-2q49A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 ARG A 199
VAL A  33
PHE A  61
GLU A  58
 None
 1.49A 5vuyA-2q49A:
undetectable
5vuyB-2q49A:
undetectable		 5vuyA-2q49A:
21.69
5vuyB-2q49A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 ARG A 199
VAL A  33
PHE A  61
GLU A  58
 None
 1.48A 6av1A-2q49A:
undetectable
6av1B-2q49A:
undetectable		 6av1A-2q49A:
11.61
6av1B-2q49A:
11.61