SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360
(Arabidopsis
thaliana) 		4 / 6 HIS A 121
LEU A 312
TYR A  17
VAL A 246
 None
 1.31A 1ibgH-2q4aA:
undetectable		 1ibgH-2q4aA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360
(Arabidopsis
thaliana) 		5 / 12 GLN A  13
ILE A  26
VAL A  64
ALA A  63
LEU A  54
 None
 1.05A 1vptA-2q4aA:
undetectable		 1vptA-2q4aA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_2
(MINERALOCORTICOID
RECEPTOR)		 2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360
(Arabidopsis
thaliana) 		4 / 4 LEU A 312
LEU A 286
MET A 159
CYH A 293
 None
 1.10A 2oaxC-2q4aA:
0.0		 2oaxC-2q4aA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360
(Arabidopsis
thaliana) 		4 / 5 LEU A 312
LEU A 286
MET A 159
CYH A 293
 None
 1.23A 2oaxD-2q4aA:
undetectable		 2oaxD-2q4aA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360
(Arabidopsis
thaliana) 		3 / 3 ARG A 322
GLU A 146
THR A 147
 SO4  A 801 (-3.3A)
None
SO4  A 801 (-2.7A)
 0.73A 3v4tA-2q4aA:
undetectable		 3v4tA-2q4aA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360
(Arabidopsis
thaliana) 		4 / 5 THR A  44
ILE A  47
LYS A  48
PHE A 134
 None
 0.88A 4ac9C-2q4aA:
undetectable		 4ac9C-2q4aA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360
(Arabidopsis
thaliana) 		4 / 5 THR A  44
ILE A  47
LYS A  48
PHE A 134
 None
 0.90A 4acaC-2q4aA:
undetectable		 4acaC-2q4aA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360
(Arabidopsis
thaliana) 		4 / 5 THR A  44
ILE A  47
LYS A  48
PHE A 134
 None
 0.80A 4acbC-2q4aA:
undetectable		 4acbC-2q4aA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360
(Arabidopsis
thaliana) 		4 / 6 ILE A  47
VAL A  64
PHE A 134
ARG A 104
 None
 1.19A 4xe5A-2q4aA:
undetectable		 4xe5A-2q4aA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360
(Arabidopsis
thaliana) 		4 / 7 LYS A 237
TYR A 156
LEU A 312
PHE A 119
 None
 1.18A 4yv5B-2q4aA:
undetectable		 4yv5B-2q4aA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M67_B_ACTB505_0
(ADENOSYLHOMOCYSTEINA
SE)		 2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360
(Arabidopsis
thaliana) 		4 / 4 ASP A 284
ILE A 288
ARG A 158
ARG A 287
 None
None
SO4  A 802 (-4.1A)
SO4  A 802 ( 4.0A)
 1.02A 5m67B-2q4aA:
0.0		 5m67B-2q4aA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M67_C_ACTC504_0
(ADENOSYLHOMOCYSTEINA
SE)		 2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360
(Arabidopsis
thaliana) 		4 / 4 ASP A 260
ILE A 191
ARG A 193
ARG A 262
 None
 1.43A 5m67C-2q4aA:
0.0		 5m67C-2q4aA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360
(Arabidopsis
thaliana) 		3 / 3 ARG A 316
LYS A 116
ARG A 179
 None
 1.05A 6c06D-2q4aA:
undetectable		 6c06D-2q4aA:
undetectable