SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q4q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 2q4q UPF0366 PROTEIN
C11ORF67
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 114
TRP A  29
 None
 0.94A 1av2C-2q4qA:
undetectable
1av2D-2q4qA:
undetectable		 1av2C-2q4qA:
8.41
1av2D-2q4qA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 2q4q UPF0366 PROTEIN
C11ORF67
(Homo
sapiens) 		3 / 3 ARG A  69
THR A  81
VAL A  77
 None
 0.95A 1hxbA-2q4qA:
undetectable		 1hxbA-2q4qA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 2q4q UPF0366 PROTEIN
C11ORF67
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 114
TRP A  29
 None
 0.95A 1w5uC-2q4qA:
undetectable
1w5uD-2q4qA:
undetectable		 1w5uC-2q4qA:
8.41
1w5uD-2q4qA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 2q4q UPF0366 PROTEIN
C11ORF67
(Homo
sapiens) 		4 / 8 THR A  64
VAL A 114
ASN A 105
ALA A 100
 None
 1.18A 2ij7C-2q4qA:
undetectable		 2ij7C-2q4qA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 2q4q UPF0366 PROTEIN
C11ORF67
(Homo
sapiens) 		4 / 4 GLU A  40
GLY A  42
THR A  43
GLU A  44
 None
 0.77A 3e9xA-2q4qA:
undetectable		 3e9xA-2q4qA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 2q4q UPF0366 PROTEIN
C11ORF67
(Homo
sapiens) 		3 / 3 VAL A  57
VAL A 114
TRP A  29
 None
 0.95A 3l8lC-2q4qA:
undetectable
3l8lD-2q4qA:
undetectable		 3l8lC-2q4qA:
8.41
3l8lD-2q4qA:
8.41