SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2q4x SEED MATURATION
PROTEIN PM36 HOMOLOG
(Arabidopsis
thaliana) 		4 / 8 ASP A  74
GLY A  70
MET A 133
ARG A 186
 None
 0.89A 1n13A-2q4xA:
undetectable
1n13F-2q4xA:
undetectable		 1n13A-2q4xA:
12.44
1n13F-2q4xA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2q4x SEED MATURATION
PROTEIN PM36 HOMOLOG
(Arabidopsis
thaliana) 		4 / 7 ASP A  74
GLY A  70
MET A 133
ARG A 186
 None
 0.86A 1n13G-2q4xA:
undetectable
1n13J-2q4xA:
undetectable		 1n13G-2q4xA:
12.44
1n13J-2q4xA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2q4x SEED MATURATION
PROTEIN PM36 HOMOLOG
(Arabidopsis
thaliana) 		4 / 8 GLU A 210
VAL A 142
TRP A  43
GLU A  88
 HMH  A1300 (-2.8A)
None
None
HMH  A1300 ( 4.8A)
 1.02A 1s3zA-2q4xA:
undetectable
1s3zB-2q4xA:
undetectable		 1s3zA-2q4xA:
22.51
1s3zB-2q4xA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 2q4x SEED MATURATION
PROTEIN PM36 HOMOLOG
(Arabidopsis
thaliana) 		4 / 5 PRO A 158
VAL A 159
VAL A  28
ILE A  30
 None
 0.83A 1z2bC-2q4xA:
undetectable		 1z2bC-2q4xA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2q4x SEED MATURATION
PROTEIN PM36 HOMOLOG
(Arabidopsis
thaliana) 		4 / 8 MET A 133
ARG A 186
ASP A  74
GLY A  70
 None
 0.84A 2qqcH-2q4xA:
undetectable
2qqcK-2q4xA:
undetectable		 2qqcH-2q4xA:
18.47
2qqcK-2q4xA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 2q4x SEED MATURATION
PROTEIN PM36 HOMOLOG
(Arabidopsis
thaliana) 		4 / 5 SER A 146
GLU A 210
THR A  22
TYR A  18
 None
HMH  A1300 (-2.8A)
None
None
 1.35A 3zs3A-2q4xA:
undetectable		 3zs3A-2q4xA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2q4x SEED MATURATION
PROTEIN PM36 HOMOLOG
(Arabidopsis
thaliana) 		5 / 7 PRO A 158
VAL A 159
PHE A  40
VAL A  28
ILE A  30
 None
 1.18A 5bmvC-2q4xA:
undetectable		 5bmvC-2q4xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 2q4x SEED MATURATION
PROTEIN PM36 HOMOLOG
(Arabidopsis
thaliana) 		4 / 6 GLU A  88
PHE A  57
TYR A 143
PHE A  92
 HMH  A1300 ( 4.8A)
None
HMH  A1300 (-3.6A)
None
 1.40A 5lrbA-2q4xA:
undetectable		 5lrbA-2q4xA:
12.74