SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 2q5c NTRC FAMILY
TRANSCRIPTIONAL
REGULATOR
(Clostridium
acetobutylicum) 		3 / 3 ASP A  51
LEU A   1
LEU A   3
 None
SO4  A 601 (-4.3A)
None
 0.54A 1ikeA-2q5cA:
undetectable		 1ikeA-2q5cA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 2q5c NTRC FAMILY
TRANSCRIPTIONAL
REGULATOR
(Clostridium
acetobutylicum) 		3 / 3 ASP A  51
LEU A   1
LEU A   3
 None
SO4  A 601 (-4.3A)
None
 0.58A 1np1B-2q5cA:
undetectable		 1np1B-2q5cA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q5c NTRC FAMILY
TRANSCRIPTIONAL
REGULATOR
(Clostridium
acetobutylicum) 		5 / 11 ILE A 175
ALA A 178
ASN A  26
LEU A   3
ALA A  52
 None
 1.01A 2aclE-2q5cA:
undetectable		 2aclE-2q5cA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 2q5c NTRC FAMILY
TRANSCRIPTIONAL
REGULATOR
(Clostridium
acetobutylicum) 		5 / 12 ILE A 155
THR A 151
ALA A  88
ARG A  90
PHE A  91
 None
 1.33A 4pbhA-2q5cA:
undetectable		 4pbhA-2q5cA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 2q5c NTRC FAMILY
TRANSCRIPTIONAL
REGULATOR
(Clostridium
acetobutylicum) 		5 / 9 ALA A 174
LEU A  15
LEU A 171
LEU A   7
ARG A  56
 None
None
None
None
GOL  A 701 ( 4.3A)
 1.25A 4x30A-2q5cA:
undetectable		 4x30A-2q5cA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2q5c NTRC FAMILY
TRANSCRIPTIONAL
REGULATOR
(Clostridium
acetobutylicum) 		3 / 3 LYS A  64
SER A  55
SER A  73
 None
 1.15A 6gbfA-2q5cA:
6.8		 6gbfA-2q5cA:
18.32