SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q5e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		6 / 12 GLY A 257
ALA A 258
ASP A 260
ILE A 251
VAL A 104
ILE A 102
 None
 1.43A 1muiB-2q5eA:
undetectable		 1muiB-2q5eA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		5 / 9 LEU A 156
PHE A 157
GLY A 257
ALA A 258
LEU A 268
 None
 0.99A 1nr6A-2q5eA:
undetectable		 1nr6A-2q5eA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		6 / 12 GLY A 257
ALA A 258
ASP A 260
ILE A 251
VAL A 104
ILE A 102
 None
 1.45A 2ienA-2q5eA:
undetectable		 2ienA-2q5eA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		4 / 5 PHE A 252
PHE A 149
LEU A 150
PHE A 183
 None
 1.27A 3abmC-2q5eA:
undetectable
3abmJ-2q5eA:
undetectable		 3abmC-2q5eA:
18.73
3abmJ-2q5eA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		4 / 5 LEU A 150
GLY A 181
GLU A 155
CYH A 159
 None
 1.11A 3aiaA-2q5eA:
undetectable
3aiaB-2q5eA:
undetectable		 3aiaA-2q5eA:
21.21
3aiaB-2q5eA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		6 / 12 GLY A 257
ALA A 258
ASP A 260
ILE A 251
VAL A 104
ILE A 102
 None
 1.32A 3jw2A-2q5eA:
undetectable		 3jw2A-2q5eA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		6 / 12 GLY A 257
ALA A 258
ASP A 260
ILE A 251
VAL A 104
ILE A 102
 None
 1.39A 3jw2B-2q5eA:
undetectable		 3jw2B-2q5eA:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		5 / 7 ASP A 109
PHE A 117
ILE A 131
SER A 165
TYR A 169
 None
 0.81A 3pglA-2q5eA:
30.8		 3pglA-2q5eA:
75.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		4 / 7 ASP A 109
SER A 165
TYR A 169
ARG A 189
 None
 0.83A 3pglA-2q5eA:
30.8		 3pglA-2q5eA:
75.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		6 / 12 GLY A 257
ALA A 258
ASP A 260
ILE A 251
VAL A 104
ILE A 102
 None
 1.41A 3tkwB-2q5eA:
undetectable		 3tkwB-2q5eA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		5 / 12 THR A 163
PHE A 188
SER A 165
LEU A 177
VAL A 113
 None
 1.37A 3u9fP-2q5eA:
undetectable
3u9fS-2q5eA:
undetectable		 3u9fP-2q5eA:
21.65
3u9fS-2q5eA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		4 / 4 LEU A 216
LEU A 150
GLN A 234
GLU A 110
 None
 1.08A 4i41A-2q5eA:
undetectable		 4i41A-2q5eA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		4 / 5 LEU A 108
ALA A 167
VAL A 127
ILE A 129
 None
 0.81A 4xe3B-2q5eA:
undetectable		 4xe3B-2q5eA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		4 / 6 PHE A 162
SER A 165
ALA A 164
LEU A 108
 None
 1.11A 5dzkB-2q5eA:
undetectable
5dzkP-2q5eA:
undetectable		 5dzkB-2q5eA:
21.74
5dzkP-2q5eA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		4 / 7 PHE A 162
SER A 165
ALA A 164
LEU A 108
 None
 0.98A 5dzkD-2q5eA:
undetectable
5dzkR-2q5eA:
undetectable		 5dzkD-2q5eA:
21.74
5dzkR-2q5eA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		4 / 6 ILE A 249
ILE A 215
LEU A 214
PHE A 157
 None
 1.01A 5vkqB-2q5eA:
undetectable
5vkqC-2q5eA:
undetectable		 5vkqB-2q5eA:
7.57
5vkqC-2q5eA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens) 		4 / 6 ILE A 249
ILE A 215
LEU A 214
PHE A 157
 None
 1.00A 5vkqC-2q5eA:
undetectable
5vkqD-2q5eA:
undetectable		 5vkqC-2q5eA:
7.57
5vkqD-2q5eA:
7.57