SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q5o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 10 GLY A 436
ASN A 441
LEU A 453
VAL A 451
ASP A 429
 None
None
None
None
MG  A4002 ( 2.7A)
 1.37A 1fpqA-2q5oA:
2.4		 1fpqA-2q5oA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 7 VAL A 148
LEU A 161
SER A  97
ALA A  76
 None
 0.68A 1j8uA-2q5oA:
undetectable		 1j8uA-2q5oA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 11 PHE A 301
ALA A 300
VAL A 222
LEU A 225
ALA A 226
 None
 0.95A 1jinA-2q5oA:
undetectable		 1jinA-2q5oA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 12 PHE A 301
ALA A 300
VAL A 222
LEU A 225
ALA A 226
 None
 0.94A 1jipA-2q5oA:
undetectable		 1jipA-2q5oA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 8 LEU A 149
VAL A 175
GLY A 176
LEU A   7
 None
 0.90A 1jlbA-2q5oA:
undetectable		 1jlbA-2q5oA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 11 SER A 281
THR A 283
ILE A 263
THR A 264
VAL A 267
 None
 1.19A 1pkvA-2q5oA:
undetectable
1pkvB-2q5oA:
undetectable		 1pkvA-2q5oA:
10.00
1pkvB-2q5oA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 11 VAL A 267
SER A 281
THR A 283
ILE A 263
THR A 264
 None
 1.16A 1pkvA-2q5oA:
undetectable
1pkvB-2q5oA:
undetectable		 1pkvA-2q5oA:
10.00
1pkvB-2q5oA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 5 LEU A 207
GLY A 239
PRO A 250
VAL A 233
 None
PPY  A5003 ( 4.1A)
None
None
 0.82A 2aojA-2q5oA:
undetectable		 2aojA-2q5oA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 12 ILE A  96
LEU A  11
VAL A 148
VAL A 175
ILE A  39
 None
 1.02A 2nnhA-2q5oA:
undetectable		 2nnhA-2q5oA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 12 GLY A 115
GLY A  73
ALA A  76
LEU A 110
LEU A 111
 None
 0.97A 2nyuA-2q5oA:
3.8		 2nyuA-2q5oA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 5 GLU A 162
PRO A 164
ILE A 163
GLY A  98
 None
 1.14A 2qeuA-2q5oA:
2.2
2qeuC-2q5oA:
undetectable		 2qeuA-2q5oA:
13.98
2qeuC-2q5oA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 6 ALA A 362
ALA A 360
THR A 386
PHE A 454
 None
 1.03A 2xfhA-2q5oA:
undetectable		 2xfhA-2q5oA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 12 ILE A  96
LEU A  11
ILE A 163
ILE A  39
PHE A  30
 None
 1.01A 2ygqA-2q5oA:
undetectable		 2ygqA-2q5oA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 MET A 380
MET A 390
PHE A 532
 None
 1.14A 3gn8A-2q5oA:
undetectable		 3gn8A-2q5oA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 PRO A 373
LEU A 374
GLN A 371
 None
 0.70A 3hznG-2q5oA:
undetectable
3hznH-2q5oA:
undetectable		 3hznG-2q5oA:
17.64
3hznH-2q5oA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 ASN A 364
ASP A 389
ARG A 214
 None
None
PPY  A5003 (-3.3A)
 0.93A 3k13C-2q5oA:
undetectable		 3k13C-2q5oA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 12 GLY A 394
ARG A  60
ALA A  57
ALA A  58
ASP A  56
 PPY  A5003 (-3.5A)
PPY  A5003 (-4.2A)
None
None
None
 1.09A 3keeA-2q5oA:
undetectable		 3keeA-2q5oA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 12 TYR A 312
ALA A 300
ILE A 315
LEU A 317
LEU A 275
 None
 1.38A 3lcvB-2q5oA:
undetectable		 3lcvB-2q5oA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 11 LEU A 525
GLY A 523
THR A 464
ASN A 472
SER A 458
 None
None
None
None
MG  A4002 ( 4.8A)
 1.35A 3ndvC-2q5oA:
undetectable
3ndvD-2q5oA:
undetectable		 3ndvC-2q5oA:
23.50
3ndvD-2q5oA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 6 ALA A 141
ILE A 145
LEU A 135
ALA A 170
 None
 0.63A 3r9sA-2q5oA:
undetectable		 3r9sA-2q5oA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 6 ALA A 141
ILE A 145
LEU A 135
ALA A 170
 None
 0.62A 3r9sC-2q5oA:
undetectable		 3r9sC-2q5oA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 8 ALA A 141
ILE A 145
LEU A 135
ALA A 170
 None
 0.68A 3r9tA-2q5oA:
undetectable		 3r9tA-2q5oA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 6 LEU A 135
ALA A  99
ARG A 134
LEU A   3
 None
 1.06A 3ravA-2q5oA:
undetectable		 3ravA-2q5oA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 6 LEU A 135
ALA A  99
ARG A 134
LEU A   3
 None
 1.08A 3rd0A-2q5oA:
undetectable		 3rd0A-2q5oA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 12 GLY A 407
GLY A 405
ASP A 379
GLU A 438
ALA A 410
 None
 1.24A 3t7sD-2q5oA:
undetectable		 3t7sD-2q5oA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 5 ARG A  14
LEU A  65
VAL A  94
ASP A 178
 None
 1.00A 3ufnA-2q5oA:
undetectable
3ufnB-2q5oA:
undetectable		 3ufnA-2q5oA:
10.99
3ufnB-2q5oA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 6 ILE A 376
VAL A 451
LEU A 515
ILE A 452
 None
 0.92A 4asdA-2q5oA:
undetectable		 4asdA-2q5oA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 6 THR A 236
VAL A 533
SER A 281
ASP A 382
 None
 1.12A 4iaqA-2q5oA:
undetectable		 4iaqA-2q5oA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 5 ILE A 376
ARG A 214
ASP A 245
VAL A 367
 None
PPY  A5003 (-3.3A)
None
None
 1.15A 4nkxC-2q5oA:
undetectable		 4nkxC-2q5oA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 5 ILE A 376
ARG A 214
ASP A 245
VAL A 367
 None
PPY  A5003 (-3.3A)
None
None
 1.15A 4nkxD-2q5oA:
undetectable		 4nkxD-2q5oA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 11 LEU A   3
ALA A 141
PRO A 142
VAL A 175
ASP A  13
 None
 1.30A 4uuuB-2q5oA:
undetectable		 4uuuB-2q5oA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 10 ALA A 141
LEU A   3
ALA A 170
LEU A   7
ALA A   4
 None
 1.15A 4zbrA-2q5oA:
undetectable		 4zbrA-2q5oA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 12 GLY A 535
LEU A 384
ILE A 376
GLY A 241
THR A 235
 None
None
None
PPY  A5003 (-4.3A)
None
 1.12A 5eskA-2q5oA:
undetectable		 5eskA-2q5oA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 5 SER A  97
VAL A  70
GLY A  75
ALA A  76
 None
 0.90A 5k50A-2q5oA:
undetectable		 5k50A-2q5oA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 9 ALA A 141
ILE A 145
ILE A 163
ALA A   4
LEU A   7
 None
 1.12A 5mvmA-2q5oA:
undetectable
5mvmE-2q5oA:
undetectable		 5mvmA-2q5oA:
9.22
5mvmE-2q5oA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.62A 5qgjA-2q5oA:
undetectable		 5qgjA-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.61A 5qglA-2q5oA:
undetectable		 5qglA-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.64A 5qgmA-2q5oA:
undetectable		 5qgmA-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.60A 5qguA-2q5oA:
undetectable		 5qguA-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.64A 5qgvA-2q5oA:
undetectable		 5qgvA-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.64A 5qgwA-2q5oA:
undetectable		 5qgwA-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.63A 5qgxA-2q5oA:
undetectable		 5qgxA-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.64A 5qgyA-2q5oA:
undetectable		 5qgyA-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.64A 5qgzA-2q5oA:
undetectable		 5qgzA-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.64A 5qh0A-2q5oA:
undetectable		 5qh0A-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.66A 5qh1A-2q5oA:
undetectable		 5qh1A-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.65A 5qh2A-2q5oA:
undetectable		 5qh2A-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.64A 5qh3A-2q5oA:
undetectable		 5qh3A-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.64A 5qh4A-2q5oA:
undetectable		 5qh4A-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.67A 5qh5A-2q5oA:
undetectable		 5qh5A-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.65A 5qh6A-2q5oA:
undetectable		 5qh6A-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.64A 5qh7A-2q5oA:
undetectable		 5qh7A-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.62A 5qh9A-2q5oA:
undetectable		 5qh9A-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.61A 5qhaA-2q5oA:
undetectable		 5qhaA-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.64A 5qhcA-2q5oA:
undetectable		 5qhcA-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.61A 5qheA-2q5oA:
undetectable		 5qheA-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.63A 5qhfA-2q5oA:
undetectable		 5qhfA-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.64A 5qhgA-2q5oA:
undetectable		 5qhgA-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		3 / 3 VAL A  83
VAL A  80
GLN A 121
 None
 0.63A 5qhhA-2q5oA:
undetectable		 5qhhA-2q5oA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 12 MET A 396
ALA A  59
ILE A 423
VAL A 417
CYH A 416
 None
 1.39A 5vlmE-2q5oA:
undetectable		 5vlmE-2q5oA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		6 / 12 PHE A 385
ALA A 402
GLY A 256
ALA A 258
SER A 281
THR A 528
 None
 1.38A 5w4zA-2q5oA:
2.1		 5w4zA-2q5oA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 6 GLY A 217
TYR A 216
LEU A 242
VAL A 222
 None
None
PPY  A5003 ( 4.7A)
None
 0.87A 5x80A-2q5oA:
undetectable
5x80B-2q5oA:
undetectable		 5x80A-2q5oA:
18.46
5x80B-2q5oA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 12 ILE A 412
GLY A  52
ALA A  50
ALA A  68
ALA A  69
 None
 1.05A 5zw4A-2q5oA:
3.1		 5zw4A-2q5oA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		4 / 7 ALA A 146
ILE A 163
LEU A 135
ILE A  39
 None
 0.84A 6b5vA-2q5oA:
undetectable
6b5vB-2q5oA:
undetectable		 6b5vA-2q5oA:
8.85
6b5vB-2q5oA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 12 LEU A 118
SER A  97
THR A  71
PHE A  77
TYR A 160
 None
None
PPY  A5001 ( 4.2A)
None
None
 1.40A 6drxA-2q5oA:
undetectable		 6drxA-2q5oA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 12 ILE A 412
GLY A 411
ILE A 423
THR A 425
ASP A 448
 None
 0.80A 6emuC-2q5oA:
undetectable		 6emuC-2q5oA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2q5o PHENYLPYRUVATE
DECARBOXYLASE
(Azospirillum
brasilense) 		5 / 11 SER A  63
GLY A 241
GLY A 394
ASP A 392
ASP A 389
 None
PPY  A5003 (-4.3A)
PPY  A5003 (-3.5A)
None
None
 1.14A 6i5zD-2q5oA:
undetectable		 6i5zD-2q5oA:
21.15