SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 404
HIS A 403
PHE A 328
LEU A 325
 None
 1.16A 1sbrA-2q66A:
2.0
1sbrB-2q66A:
undetectable		 1sbrA-2q66A:
16.19
1sbrB-2q66A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 150
ILE A 151
SER A 152
ILE A 153
LEU A  55
 None
 0.93A 2kawA-2q66A:
undetectable		 2kawA-2q66A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 521
GLY A 467
VAL A 512
ASP A 469
 None
 0.92A 2y05A-2q66A:
undetectable
2y05B-2q66A:
undetectable		 2y05A-2q66A:
20.96
2y05B-2q66A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 164
GLY A  82
ASP A  79
PRO A 108
HIS A 110
 None
 0.85A 3fuuA-2q66A:
undetectable		 3fuuA-2q66A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  92
VAL A 201
ILE A 255
LEU A 211
ILE A 214
 None
 1.13A 3ijdA-2q66A:
undetectable		 3ijdA-2q66A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 528
PHE A 355
ASP A 523
PRO A 518
 None
None
EDO  A 710 (-3.1A)
None
 1.36A 3jqaB-2q66A:
undetectable		 3jqaB-2q66A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 144
PHE A 116
ASP A 115
GLU A 114
 None
 1.05A 3kp6A-2q66A:
1.6
3kp6B-2q66A:
2.1		 3kp6A-2q66A:
15.98
3kp6B-2q66A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 510
GLU A 434
THR A 433
 None
 0.79A 3v4tA-2q66A:
undetectable		 3v4tA-2q66A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  58
GLN A  60
PHE A 120
LEU A 124
 None
 0.89A 3x2qC-2q66A:
undetectable
3x2qJ-2q66A:
undetectable		 3x2qC-2q66A:
18.08
3x2qJ-2q66A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  52
LEU A  55
LEU A  58
ALA A  59
THR A  86
 EDO  A 714 ( 4.0A)
None
None
None
None
 1.24A 4fn9B-2q66A:
undetectable		 4fn9B-2q66A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 102
ASN A 226
ALA A 225
ASP A 100
 MG  A 602 ( 2.6A)
ATP  A 605 (-3.5A)
None
MG  A 602 ( 2.6A)
 1.15A 4mdaA-2q66A:
undetectable		 4mdaA-2q66A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 413
GLU A 363
THR A 463
LEU A 437
 None
 1.38A 4qzuC-2q66A:
undetectable		 4qzuC-2q66A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  58
GLU A  65
ILE A 144
PRO A 108
 None
 0.96A 4xi3C-2q66A:
undetectable		 4xi3C-2q66A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  58
GLN A  60
PHE A 120
LEU A 124
 None
 0.95A 5b1aC-2q66A:
undetectable
5b1aJ-2q66A:
undetectable		 5b1aC-2q66A:
18.08
5b1aJ-2q66A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  58
GLN A  60
PHE A 120
LEU A 124
 None
 0.92A 5b1aP-2q66A:
undetectable
5b1aW-2q66A:
undetectable		 5b1aP-2q66A:
18.08
5b1aW-2q66A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  58
GLN A  60
PHE A 120
LEU A 124
 None
 0.92A 5b3sC-2q66A:
undetectable
5b3sJ-2q66A:
undetectable		 5b3sC-2q66A:
18.08
5b3sJ-2q66A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  58
GLN A  60
PHE A 120
LEU A 124
 None
 0.93A 5b3sP-2q66A:
undetectable		 5b3sP-2q66A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 6 GLY A  88
ILE A 209
ARG A 212
TYR A 224
 ATP  A 605 (-3.2A)
None
None
ATP  A 605 (-4.5A)
 1.02A 5iwuA-2q66A:
undetectable		 5iwuA-2q66A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  58
GLN A  60
PHE A 120
LEU A 124
 None
 0.97A 5iy5C-2q66A:
undetectable
5iy5J-2q66A:
undetectable		 5iy5C-2q66A:
17.86
5iy5J-2q66A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 127
THR A 103
ILE A 153
LEU A 155
 None
 0.98A 5te8C-2q66A:
1.4		 5te8C-2q66A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  58
GLN A  60
PHE A 120
LEU A 124
 None
 0.94A 5z85C-2q66A:
undetectable
5z85J-2q66A:
undetectable		 5z85C-2q66A:
18.08
5z85J-2q66A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  85
VAL A 165
LEU A 176
LEU A 171
 None
 1.01A 6e43B-2q66A:
undetectable		 6e43B-2q66A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2q66 POLY(A) POLYMERASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  85
VAL A 165
LEU A 176
LEU A 171
 None
 0.93A 6e43D-2q66A:
undetectable		 6e43D-2q66A:
21.85