SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q6d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		5 / 12 ILE A 112
LEU A 139
SER A 137
TYR A 116
ILE A 121
 None
 1.23A 1fmlB-2q6dA:
undetectable		 1fmlB-2q6dA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		5 / 10 LEU A 224
ILE A 282
PHE A 246
THR A 199
ILE A 202
 None
 1.43A 1i18A-2q6dA:
2.1
1i18B-2q6dA:
2.0		 1i18A-2q6dA:
14.33
1i18B-2q6dA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		4 / 6 HIS A  41
ASP A 174
THR A 173
TYR A 159
 None
 1.29A 2dysA-2q6dA:
undetectable
2dysC-2q6dA:
undetectable		 2dysA-2q6dA:
21.14
2dysC-2q6dA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		4 / 6 HIS A  41
ASP A 174
THR A 173
TYR A 159
 None
 1.30A 2dysN-2q6dA:
undetectable
2dysP-2q6dA:
undetectable		 2dysN-2q6dA:
21.14
2dysP-2q6dA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		4 / 7 HIS A  41
ASP A 174
THR A 173
TYR A 159
 None
 1.29A 2eijA-2q6dA:
undetectable
2eijC-2q6dA:
undetectable		 2eijA-2q6dA:
21.14
2eijC-2q6dA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		4 / 7 HIS A  41
ASP A 174
THR A 173
TYR A 159
 None
 1.31A 2eilA-2q6dA:
undetectable
2eilC-2q6dA:
undetectable		 2eilA-2q6dA:
21.14
2eilC-2q6dA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		4 / 6 HIS A  41
ASP A 174
THR A 173
TYR A 159
 None
 1.32A 2eimN-2q6dA:
undetectable
2eimP-2q6dA:
undetectable		 2eimN-2q6dA:
21.14
2eimP-2q6dA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		4 / 6 HIS A  41
ASP A 174
THR A 173
TYR A 159
 None
 1.35A 2einA-2q6dA:
undetectable
2einC-2q6dA:
undetectable		 2einA-2q6dA:
21.14
2einC-2q6dA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		4 / 6 ASP A 195
ARG A 129
THR A 127
ASP A 290
 None
 1.02A 2j2pE-2q6dA:
undetectable
2j2pF-2q6dA:
undetectable		 2j2pE-2q6dA:
20.71
2j2pF-2q6dA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		3 / 3 ASN A  25
LEU A  27
HIS A  41
 None
 0.39A 2q6fB-2q6dA:
43.3		 2q6fB-2q6dA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		4 / 7 HIS A  41
ASP A 174
THR A 173
TYR A 159
 None
 1.32A 3abmN-2q6dA:
undetectable
3abmP-2q6dA:
undetectable		 3abmN-2q6dA:
21.14
3abmP-2q6dA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		4 / 7 HIS A  41
ASP A 174
THR A 173
TYR A 159
 None
 1.28A 3ag3N-2q6dA:
undetectable
3ag3P-2q6dA:
undetectable		 3ag3N-2q6dA:
21.14
3ag3P-2q6dA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		4 / 7 HIS A  41
ASP A 174
THR A 173
TYR A 159
 None
 1.30A 3ag4A-2q6dA:
undetectable
3ag4C-2q6dA:
undetectable		 3ag4A-2q6dA:
21.14
3ag4C-2q6dA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		5 / 9 VAL A 146
PHE A 157
ILE A  17
ALA A  12
VAL A 120
 None
 1.25A 3me6C-2q6dA:
undetectable		 3me6C-2q6dA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		5 / 9 VAL A 146
PHE A 157
ILE A  17
ALA A  12
VAL A 120
 None
 1.18A 3me6D-2q6dA:
undetectable		 3me6D-2q6dA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		4 / 7 VAL A  42
ILE A  86
VAL A  18
VAL A  65
 None
 0.81A 3ufnB-2q6dA:
undetectable		 3ufnB-2q6dA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		5 / 12 ILE A 252
THR A 199
LEU A 255
GLU A 295
VAL A 297
 None
 1.25A 5hw4A-2q6dA:
undetectable		 5hw4A-2q6dA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		5 / 12 THR A 199
ALA A 204
LEU A 255
GLU A 295
VAL A 297
 None
 1.19A 5hw4A-2q6dA:
undetectable		 5hw4A-2q6dA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		5 / 12 THR A 199
ALA A 204
LEU A 255
GLU A 295
VAL A 297
 None
 1.18A 5hw4C-2q6dA:
undetectable		 5hw4C-2q6dA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		4 / 7 HIS A  41
ASP A 174
THR A 173
TYR A 159
 None
 1.26A 6nmfN-2q6dA:
undetectable
6nmfP-2q6dA:
undetectable		 6nmfN-2q6dA:
21.14
6nmfP-2q6dA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		4 / 6 HIS A  41
ASP A 174
THR A 173
TYR A 159
 None
 1.31A 6nmpA-2q6dA:
undetectable
6nmpC-2q6dA:
undetectable		 6nmpA-2q6dA:
21.14
6nmpC-2q6dA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q6d INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
(Avian
coronavirus) 		4 / 7 HIS A  41
ASP A 174
THR A 173
TYR A 159
 None
 1.32A 6nmpN-2q6dA:
undetectable
6nmpP-2q6dA:
undetectable		 6nmpN-2q6dA:
21.14
6nmpP-2q6dA:
21.00