SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		4 / 8 ARG A 157
LEU A 162
GLU A 165
HIS A 169
 None
 0.67A 1cmaA-2q6tA:
undetectable
1cmaB-2q6tA:
undetectable		 1cmaA-2q6tA:
14.15
1cmaB-2q6tA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		4 / 8 LEU A 280
ALA A 225
GLY A 233
ILE A 234
 None
 0.79A 1d4sB-2q6tA:
undetectable		 1d4sB-2q6tA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		4 / 8 HIS A  45
ILE A  48
VAL A  30
MET A  27
 None
 1.06A 1kb9A-2q6tA:
undetectable
1kb9C-2q6tA:
undetectable
1kb9D-2q6tA:
undetectable
1kb9E-2q6tA:
undetectable		 1kb9A-2q6tA:
22.65
1kb9C-2q6tA:
20.43
1kb9D-2q6tA:
21.62
1kb9E-2q6tA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		4 / 7 ALA A 215
ARG A 247
TYR A 400
PHE A 430
 None
 1.09A 2ajvH-2q6tA:
undetectable
2ajvL-2q6tA:
undetectable		 2ajvH-2q6tA:
18.14
2ajvL-2q6tA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		3 / 3 ARG A 334
GLY A 324
PRO A 325
 None
 0.64A 2hreD-2q6tA:
undetectable		 2hreD-2q6tA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		5 / 11 HIS A 169
SER A 201
GLY A 353
ILE A 354
VAL A 230
 None
 1.11A 2uxpB-2q6tA:
1.9		 2uxpB-2q6tA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		5 / 12 ALA A 207
THR A 219
PHE A 187
ILE A 413
PHE A 216
 None
 1.17A 2v95A-2q6tA:
undetectable		 2v95A-2q6tA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		5 / 12 GLY A 186
ALA A 217
ILE A 357
LEU A 313
VAL A 230
 None
 0.93A 3adsB-2q6tA:
undetectable		 3adsB-2q6tA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		5 / 12 GLY A 186
ALA A 217
ILE A 357
LEU A 313
VAL A 230
 None
 0.95A 3adxB-2q6tA:
undetectable		 3adxB-2q6tA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		5 / 12 GLY A 233
ASP A 288
GLY A 312
LEU A 352
ILE A 354
 None
 1.02A 3ku1G-2q6tA:
undetectable		 3ku1G-2q6tA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		4 / 7 LEU A 280
ALA A 225
GLY A 233
ILE A 234
 None
 0.70A 3spkB-2q6tA:
undetectable		 3spkB-2q6tA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		5 / 10 ALA A 224
ILE A 285
GLY A 233
ILE A 314
ALA A 217
 None
 1.04A 3t3cB-2q6tA:
undetectable		 3t3cB-2q6tA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		4 / 6 LEU A 190
PHE A 216
ALA A 217
LEU A 197
 None
 0.74A 3t3zA-2q6tA:
undetectable		 3t3zA-2q6tA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		4 / 6 LEU A 190
PHE A 216
ALA A 217
LEU A 197
 None
 0.78A 3t3zB-2q6tA:
undetectable		 3t3zB-2q6tA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		4 / 6 LEU A 190
PHE A 216
ALA A 217
LEU A 197
 None
 0.77A 3t3zD-2q6tA:
undetectable		 3t3zD-2q6tA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		5 / 12 LEU A 345
ALA A 217
ILE A 338
LEU A 379
GLY A 383
 None
 1.14A 4l9qB-2q6tA:
undetectable		 4l9qB-2q6tA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		3 / 3 ASP A 191
LEU A 190
PHE A 187
 None
 0.48A 4pthA-2q6tA:
1.5		 4pthA-2q6tA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		4 / 6 ASP A 378
ILE A 414
ARG A 373
TYR A 396
 None
 1.08A 5igyA-2q6tA:
undetectable		 5igyA-2q6tA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		4 / 6 ASP A 378
ILE A 414
ARG A 373
TYR A 396
 None
 1.08A 5iwuA-2q6tA:
undetectable		 5iwuA-2q6tA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		5 / 12 MET A 248
ALA A 215
GLU A 238
LEU A 244
ILE A 234
 None
 1.12A 5vlmG-2q6tA:
undetectable		 5vlmG-2q6tA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2q6t DNAB REPLICATION
FORK HELICASE
(Thermus
aquaticus) 		5 / 12 LEU A 359
VAL A 415
THR A 219
LEU A 218
ALA A 221
 None
 1.17A 6djzC-2q6tA:
undetectable		 6djzC-2q6tA:
19.68