SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 7 PRO A  14
VAL A  15
THR A 155
LEU A 156
 FAD  A 401 ( 3.4A)
FAD  A 401 ( 3.8A)
None
None
 1.00A 1jgsA-2q6uA:
undetectable		 1jgsA-2q6uA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 7 ILE A 228
ARG A  50
LEU A 322
GLY A  47
 None
FAD  A 401 ( 4.1A)
None
None
 0.89A 1mt1H-2q6uA:
0.7
1mt1K-2q6uA:
undetectable		 1mt1H-2q6uA:
14.07
1mt1K-2q6uA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 8 LEU A 322
GLY A  47
ILE A 228
ARG A  50
 None
None
None
FAD  A 401 ( 4.1A)
 0.87A 1n13A-2q6uA:
undetectable
1n13F-2q6uA:
undetectable		 1n13A-2q6uA:
8.92
1n13F-2q6uA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 8 THR A  95
GLY A 106
THR A 107
ALA A 108
 None
 0.79A 2a1hA-2q6uA:
undetectable
2a1hB-2q6uA:
undetectable		 2a1hA-2q6uA:
24.48
2a1hB-2q6uA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 8 THR A  95
GLY A 106
THR A 107
ALA A 108
 None
 0.81A 2a1hA-2q6uA:
undetectable
2a1hB-2q6uA:
undetectable		 2a1hA-2q6uA:
24.48
2a1hB-2q6uA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		3 / 3 ARG A  29
VAL A 200
GLY A  11
 None
None
FAD  A 401 ( 3.3A)
 0.56A 2avvE-2q6uA:
undetectable		 2avvE-2q6uA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 6 PHE A 132
THR A 310
VAL A 311
LEU A 304
 None
 1.01A 2e1qA-2q6uA:
undetectable		 2e1qA-2q6uA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 6 PHE A 132
THR A 310
VAL A 311
LEU A 304
 None
 1.04A 2e1qC-2q6uA:
undetectable		 2e1qC-2q6uA:
15.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q6U_A_BEZA501_0
(NIKD PROTEIN)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		7 / 7 HIS A  51
ARG A  53
GLU A 101
PHE A 242
TYR A 258
TRP A 355
LYS A 358
 BEZ  A 501 ( 4.5A)
BEZ  A 501 ( 4.1A)
BEZ  A 501 ( 2.6A)
BEZ  A 501 ( 4.5A)
BEZ  A 501 ( 3.8A)
BEZ  A 501 ( 3.5A)
BEZ  A 501 ( 2.6A)
 0.01A 2q6uA-2q6uA:
71.1		 2q6uA-2q6uA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 7 GLY A 102
THR A  99
GLN A 332
PHE A 359
 None
 1.03A 2qx4A-2q6uA:
undetectable
2qx4B-2q6uA:
undetectable		 2qx4A-2q6uA:
20.00
2qx4B-2q6uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		5 / 10 ARG A  53
LEU A 362
THR A  65
ILE A 228
GLY A 354
 BEZ  A 501 ( 4.1A)
None
None
None
None
 1.30A 2v0mA-2q6uA:
undetectable		 2v0mA-2q6uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 8 PHE A 132
THR A 310
VAL A 311
LEU A 304
 None
 0.97A 3ax7A-2q6uA:
undetectable		 3ax7A-2q6uA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 5 VAL A  97
VAL A  98
THR A 254
THR A  95
 None
 1.14A 3bjwA-2q6uA:
undetectable		 3bjwA-2q6uA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 5 VAL A 201
VAL A   9
PHE A 363
ARG A  35
 None
None
None
FAD  A 401 ( 4.2A)
 1.32A 3bjwH-2q6uA:
undetectable		 3bjwH-2q6uA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 5 VAL A  97
VAL A  98
THR A 254
THR A  95
 None
 1.09A 3bjwG-2q6uA:
undetectable		 3bjwG-2q6uA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		5 / 12 PHE A 142
ILE A 104
GLN A  58
THR A  99
THR A  65
 None
 1.30A 3em0B-2q6uA:
undetectable		 3em0B-2q6uA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 7 GLY A  11
THR A  19
GLU A  34
ALA A 203
 FAD  A 401 ( 3.3A)
None
FAD  A 401 ( 2.8A)
None
 0.77A 3fpjB-2q6uA:
4.6		 3fpjB-2q6uA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 7 PHE A 132
THR A 310
VAL A 311
LEU A 304
 None
 0.99A 3uniA-2q6uA:
undetectable		 3uniA-2q6uA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 8 LEU A 335
VAL A 201
VAL A  15
LEU A 370
 None
None
FAD  A 401 ( 3.8A)
None
 1.01A 3v81C-2q6uA:
undetectable		 3v81C-2q6uA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 8 GLY A  11
GLY A 205
TYR A 221
VAL A 350
 FAD  A 401 ( 3.3A)
FAD  A 401 ( 4.1A)
None
None
 0.83A 4fgzA-2q6uA:
3.1		 4fgzA-2q6uA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 8 GLY A  13
GLY A  43
LEU A 322
VAL A 324
 FAD  A 401 ( 3.5A)
FAD  A 401 ( 3.9A)
None
None
 0.81A 4fgzA-2q6uA:
3.1		 4fgzA-2q6uA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 8 GLY A  11
GLY A 205
TYR A 221
VAL A 350
 FAD  A 401 ( 3.3A)
FAD  A 401 ( 4.1A)
None
None
 0.84A 4fgzB-2q6uA:
3.2		 4fgzB-2q6uA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 8 ALA A 323
GLY A 354
LEU A 325
GLU A 101
 FAD  A 401 ( 4.1A)
None
None
BEZ  A 501 ( 2.6A)
 0.86A 4po0A-2q6uA:
undetectable		 4po0A-2q6uA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 8 LEU A 335
VAL A 201
VAL A  15
LEU A 370
 None
None
FAD  A 401 ( 3.8A)
None
 1.03A 4pwdA-2q6uA:
2.1		 4pwdA-2q6uA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 8 LEU A 335
VAL A 201
VAL A  15
LEU A 370
 None
None
FAD  A 401 ( 3.8A)
None
 1.08A 4q0bA-2q6uA:
undetectable		 4q0bA-2q6uA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		4 / 8 TYR A  56
THR A 107
HIS A  51
TRP A  52
 None
None
BEZ  A 501 ( 4.5A)
None
 1.50A 4tzcB-2q6uA:
0.0
4tzcD-2q6uA:
undetectable		 4tzcB-2q6uA:
12.53
4tzcD-2q6uA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2q6u NIKD PROTEIN
(Streptomyces
tendae) 		6 / 12 GLY A  12
GLY A  11
VAL A  15
ALA A  18
LEU A  17
ALA A 163
 FAD  A 401 ( 4.9A)
FAD  A 401 ( 3.3A)
FAD  A 401 ( 3.8A)
None
None
None
 1.42A 5kpcA-2q6uA:
undetectable		 5kpcA-2q6uA:
20.79