SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q6z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 ALA A 262
ILE A 260
PHE A 229
LEU A 301
LEU A 282
 None
 1.17A 1dtlA-2q6zA:
undetectable		 1dtlA-2q6zA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 GLY A 265
PRO A 226
GLY A 225
PHE A 261
LEU A 282
 None
 0.90A 1eizA-2q6zA:
undetectable		 1eizA-2q6zA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 GLY A 265
PRO A 226
GLY A 225
PHE A 261
LEU A 282
 None
 0.90A 1ej0A-2q6zA:
undetectable		 1ej0A-2q6zA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 6 LEU A 131
LEU A 161
LEU A 248
LEU A 253
 None
 0.92A 1errA-2q6zA:
undetectable		 1errA-2q6zA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		5 / 11 LEU A 181
PRO A 226
TRP A 159
LEU A 228
TYR A 182
 None
 1.45A 1klmA-2q6zA:
undetectable		 1klmA-2q6zA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 5 LEU A 131
VAL A 134
ALA A  64
CYH A  65
 None
 0.94A 1mz9C-2q6zA:
undetectable		 1mz9C-2q6zA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 5 LEU A 131
VAL A 134
ALA A  64
CYH A  65
 None
 0.96A 1mz9D-2q6zA:
undetectable		 1mz9D-2q6zA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 LEU A 216
GLN A 215
PHE A 154
LEU A 199
 None
 1.07A 1v55C-2q6zA:
undetectable
1v55J-2q6zA:
undetectable		 1v55C-2q6zA:
20.71
1v55J-2q6zA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		5 / 11 GLY A 276
ALA A 275
ILE A 259
ALA A 157
ILE A 237
 None
 1.00A 2b60B-2q6zA:
undetectable		 2b60B-2q6zA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		5 / 9 GLY A 351
GLU A 348
ILE A 317
ALA A 356
VAL A 321
 None
 1.31A 2drdA-2q6zA:
undetectable		 2drdA-2q6zA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 LEU A 216
GLN A 215
PHE A 154
LEU A 199
 None
 1.06A 2einC-2q6zA:
undetectable
2einJ-2q6zA:
undetectable		 2einC-2q6zA:
20.71
2einJ-2q6zA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 6 LEU A 216
GLN A 215
PHE A 154
LEU A 199
 None
 1.07A 2einP-2q6zA:
undetectable
2einW-2q6zA:
undetectable		 2einP-2q6zA:
20.71
2einW-2q6zA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 GLY A 276
ALA A 275
ILE A 259
ALA A 157
ILE A 237
 None
 0.95A 2nmyB-2q6zA:
undetectable		 2nmyB-2q6zA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7I_A_TESA205_1
(ANDROGEN RECEPTOR)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 LEU A 118
LEU A 121
MET A 162
MET A 165
VAL A 166
 None
 1.21A 2q7iA-2q6zA:
undetectable		 2q7iA-2q6zA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 LEU A 118
LEU A 121
MET A 162
MET A 165
VAL A 166
 None
 1.20A 2yloA-2q6zA:
undetectable		 2yloA-2q6zA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 LYS A 245
ARG A 193
TYR A 236
GLU A 278
 None
 1.30A 3dh0A-2q6zA:
undetectable		 3dh0A-2q6zA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 4 ILE A 334
GLN A 302
VAL A 279
PHE A  19
 None
 1.13A 3ieoA-2q6zA:
undetectable		 3ieoA-2q6zA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 6 PHE A  84
CYH A  65
VAL A  89
PHE A  55
 None
 1.35A 3ltwA-2q6zA:
undetectable		 3ltwA-2q6zA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 TYR A  42
LEU A 305
LEU A 341
PHE A  76
 None
 1.23A 3nk2X-2q6zA:
undetectable		 3nk2X-2q6zA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 5 VAL A  33
ILE A  82
PHE A 154
PHE A 217
 None
 0.77A 3owxB-2q6zA:
undetectable		 3owxB-2q6zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 HIS A 349
GLY A 351
GLU A 348
PHE A  76
 None
 1.01A 3tehB-2q6zA:
undetectable		 3tehB-2q6zA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 LEU A 216
GLN A 215
PHE A 154
LEU A 199
 None
 0.92A 3x2qC-2q6zA:
undetectable
3x2qJ-2q6zA:
undetectable		 3x2qC-2q6zA:
20.71
3x2qJ-2q6zA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 LEU A 216
GLN A 215
PHE A 154
LEU A 199
 None
 0.93A 3x2qP-2q6zA:
undetectable
3x2qW-2q6zA:
undetectable		 3x2qP-2q6zA:
20.71
3x2qW-2q6zA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 LEU A 118
LEU A 121
MET A 162
MET A 165
VAL A 166
 None
 1.20A 3zqtA-2q6zA:
undetectable		 3zqtA-2q6zA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		3 / 3 TYR A  30
HIS A 358
ARG A 362
 None
 0.81A 4e7bC-2q6zA:
undetectable		 4e7bC-2q6zA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 VAL A 149
PRO A  32
GLN A  38
ILE A 152
 None
 1.07A 4iilA-2q6zA:
2.5		 4iilA-2q6zA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		5 / 12 GLU A  97
GLN A  92
ARG A 122
VAL A 127
LEU A 199
 None
 1.44A 4k38B-2q6zA:
3.7		 4k38B-2q6zA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 6 LEU A 305
THR A  31
ALA A 335
LEU A 337
 None
 1.03A 4pwjA-2q6zA:
undetectable		 4pwjA-2q6zA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 LEU A 216
GLN A 215
PHE A 154
LEU A 199
 None
 0.95A 5b1aC-2q6zA:
undetectable
5b1aJ-2q6zA:
undetectable		 5b1aC-2q6zA:
20.71
5b1aJ-2q6zA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 LEU A 216
GLN A 215
PHE A 154
LEU A 199
 None
 0.90A 5b1aP-2q6zA:
undetectable
5b1aW-2q6zA:
undetectable		 5b1aP-2q6zA:
20.71
5b1aW-2q6zA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 LEU A 216
GLN A 215
PHE A 154
LEU A 199
 None
 0.95A 5b3sC-2q6zA:
undetectable
5b3sJ-2q6zA:
undetectable		 5b3sC-2q6zA:
20.71
5b3sJ-2q6zA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 LEU A 216
GLN A 215
PHE A 154
LEU A 199
 None
 0.92A 5b3sP-2q6zA:
undetectable		 5b3sP-2q6zA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		3 / 3 TYR A 342
TYR A 164
SER A 219
 None
 0.75A 5iktB-2q6zA:
undetectable		 5iktB-2q6zA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 SER A  85
PHE A  56
GLN A  92
MET A 100
 None
 1.43A 5u6nA-2q6zA:
3.6		 5u6nA-2q6zA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 8 GLU A 278
PHE A 154
SER A 219
MET A  36
 None
 1.08A 5y2tB-2q6zA:
undetectable		 5y2tB-2q6zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 LEU A 216
GLN A 215
PHE A 154
LEU A 199
 None
 0.94A 5zcoC-2q6zA:
undetectable
5zcoJ-2q6zA:
undetectable		 5zcoC-2q6zA:
20.71
5zcoJ-2q6zA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens) 		4 / 7 LEU A 216
GLN A 215
PHE A 154
LEU A 199
 None
 0.92A 5zcqP-2q6zA:
undetectable
5zcqW-2q6zA:
undetectable		 5zcqP-2q6zA:
20.71
5zcqW-2q6zA:
9.43