SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q74'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 225
ALA A 267
LEU A 177
ALA A 175
LEU A 251
 None
 0.98A 1fm6A-2q74A:
undetectable		 1fm6A-2q74A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 225
ALA A 267
LEU A 177
ALA A 175
LEU A 251
 None
 0.97A 1fm9A-2q74A:
undetectable		 1fm9A-2q74A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 228
THR A 109
VAL A 110
ALA A 211
 None
 0.89A 1fo4B-2q74A:
undetectable		 1fo4B-2q74A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 112
TYR A 119
ILE A 106
VAL A  59
 None
 0.86A 1fslB-2q74A:
undetectable		 1fslB-2q74A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		4 / 8 GLU A  84
GLU A  64
ASP A  54
GLU A  83
 None
 1.14A 1knyA-2q74A:
undetectable
1knyB-2q74A:
undetectable		 1knyA-2q74A:
19.24
1knyB-2q74A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 147
SER A 146
ALA A 135
PRO A   8
GLY A 152
 None
 1.29A 2igtC-2q74A:
undetectable		 2igtC-2q74A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 205
GLY A 180
THR A 179
GLY A 209
 None
 0.45A 3aruA-2q74A:
undetectable		 3aruA-2q74A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		6 / 12 VAL A 144
ALA A 153
ALA A 147
LEU A 241
LEU A 164
ALA A 246
 None
 1.32A 3fc6C-2q74A:
undetectable		 3fc6C-2q74A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		4 / 6 SER A 146
TYR A 145
ALA A 147
ARG A 161
 None
 0.95A 3ravA-2q74A:
undetectable		 3ravA-2q74A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		5 / 7 LEU A 155
ASP A 214
VAL A 136
ILE A 116
THR A 143
 None
 1.39A 4eyrA-2q74A:
undetectable		 4eyrA-2q74A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 263
GLY A 230
LYS A 260
 None
 0.76A 4k50A-2q74A:
undetectable		 4k50A-2q74A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 263
GLY A 230
LYS A 260
 None
 0.74A 4k50E-2q74A:
undetectable		 4k50E-2q74A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 263
GLY A 230
LYS A 260
 None
 0.75A 4k50I-2q74A:
undetectable		 4k50I-2q74A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		5 / 12 CYH A 216
GLY A 134
ILE A 123
ALA A  19
ALA A 125
 None
 1.14A 4kicA-2q74A:
undetectable		 4kicA-2q74A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 164
GLU A 245
VAL A 250
ALA A 266
 None
 0.84A 4nkxA-2q74A:
undetectable		 4nkxA-2q74A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		5 / 8 ALA A 212
ALA A 238
ALA A 135
ALA A 137
ALA A 120
 None
 1.25A 4twdF-2q74A:
2.1
4twdG-2q74A:
undetectable
4twdH-2q74A:
undetectable
4twdI-2q74A:
undetectable
4twdJ-2q74A:
undetectable		 4twdF-2q74A:
20.87
4twdG-2q74A:
20.87
4twdH-2q74A:
20.87
4twdI-2q74A:
20.87
4twdJ-2q74A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  18
LEU A  11
LYS A  98
ALA A 125
ILE A  80
 None
 1.15A 4x1kD-2q74A:
undetectable		 4x1kD-2q74A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 2q74 INOSITOL-1-MONOPHOSP
HATASE
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 107
VAL A 264
GLY A 239
ALA A 240
 None
 0.97A 5hwaA-2q74A:
undetectable		 5hwaA-2q74A:
20.58