SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q7v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		4 / 5 GLY A 168
LEU A 171
THR A 172
VAL A 157
 None
 0.73A 1ekjF-2q7vA:
undetectable
1ekjG-2q7vA:
undetectable		 1ekjF-2q7vA:
22.42
1ekjG-2q7vA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		4 / 5 ASP A 267
VAL A 268
SER A 286
ASP A 262
 None
 1.48A 1n2xB-2q7vA:
4.2		 1n2xB-2q7vA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		5 / 12 GLY A  15
GLY A  16
GLU A  38
ASP A  85
ASN A 250
 FAD  A 348 (-3.3A)
FAD  A 348 ( 4.9A)
FAD  A 348 (-2.7A)
None
FAD  A 348 ( 4.1A)
 1.02A 1qzzA-2q7vA:
3.3		 1qzzA-2q7vA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		5 / 12 PHE A 244
ILE A 206
GLY A 159
THR A 209
VAL A 211
 None
 1.14A 1sg9A-2q7vA:
3.9		 1sg9A-2q7vA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		5 / 12 GLY A  15
GLY A  16
GLU A  38
ASP A  85
ASN A 250
 FAD  A 348 (-3.3A)
FAD  A 348 ( 4.9A)
FAD  A 348 (-2.7A)
None
FAD  A 348 ( 4.1A)
 1.17A 1xdsA-2q7vA:
3.3		 1xdsA-2q7vA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		5 / 12 GLY A  15
GLY A  16
GLU A  38
ASP A  85
ASN A 250
 FAD  A 348 (-3.3A)
FAD  A 348 ( 4.9A)
FAD  A 348 (-2.7A)
None
FAD  A 348 ( 4.1A)
 1.09A 1xdsB-2q7vA:
3.1		 1xdsB-2q7vA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		4 / 7 PHE A 253
THR A 251
VAL A 285
VAL A 258
 FAD  A 348 ( 4.0A)
None
None
None
 1.05A 2cppA-2q7vA:
undetectable		 2cppA-2q7vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		4 / 6 LEU A 293
SER A 296
ASP A 284
ASP A 287
 FAD  A 348 (-3.6A)
FAD  A 348 (-3.3A)
FAD  A 348 (-3.0A)
None
 1.09A 2j2pE-2q7vA:
undetectable
2j2pF-2q7vA:
undetectable		 2j2pE-2q7vA:
17.77
2j2pF-2q7vA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		4 / 6 PRO A  42
GLY A  17
ILE A  13
GLY A  15
 None
FAD  A 348 (-3.4A)
None
FAD  A 348 (-3.3A)
 0.86A 2jkjA-2q7vA:
undetectable		 2jkjA-2q7vA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		4 / 6 PRO A  42
GLY A  17
ILE A  13
GLY A  15
 None
FAD  A 348 (-3.4A)
None
FAD  A 348 (-3.3A)
 0.86A 2jkjB-2q7vA:
undetectable		 2jkjB-2q7vA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		4 / 6 PRO A  42
GLY A  17
ILE A  13
GLY A  15
 None
FAD  A 348 (-3.4A)
None
FAD  A 348 (-3.3A)
 0.87A 2jkjC-2q7vA:
undetectable		 2jkjC-2q7vA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		4 / 7 PRO A  42
GLY A  17
ILE A  13
GLY A  15
 None
FAD  A 348 (-3.4A)
None
FAD  A 348 (-3.3A)
 0.85A 2jkjE-2q7vA:
undetectable		 2jkjE-2q7vA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		4 / 7 GLY A  20
GLY A 300
THR A  27
GLU A  38
 None
None
None
FAD  A 348 (-2.7A)
 0.86A 3fpjB-2q7vA:
4.0		 3fpjB-2q7vA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		5 / 10 GLY A 168
ALA A 189
VAL A 165
GLU A 166
VAL A 180
 None
 1.14A 4da7A-2q7vA:
undetectable		 4da7A-2q7vA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		5 / 9 ALA A 303
ILE A  14
GLY A  20
ALA A  19
VAL A 285
 None
None
None
FAD  A 348 (-3.3A)
None
 1.24A 4r1zA-2q7vA:
undetectable		 4r1zA-2q7vA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		4 / 8 ALA A 282
GLY A 300
ALA A  23
GLY A  20
 None
 0.66A 4zjzA-2q7vA:
undetectable		 4zjzA-2q7vA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		4 / 7 ILE A 158
VAL A 211
ILE A 128
GLU A 131
 None
 0.90A 4zzbC-2q7vA:
undetectable
4zzbD-2q7vA:
undetectable		 4zzbC-2q7vA:
21.59
4zzbD-2q7vA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		4 / 7 VAL A 254
THR A 251
LEU A 279
THR A 274
 None
 1.01A 5e4dA-2q7vA:
undetectable
5e4dB-2q7vA:
undetectable		 5e4dA-2q7vA:
19.82
5e4dB-2q7vA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		5 / 9 LEU A 117
ILE A  14
GLY A  15
GLY A  20
LEU A 279
 None
None
FAD  A 348 (-3.3A)
None
None
 0.88A 5o96A-2q7vA:
2.8
5o96B-2q7vA:
2.8		 5o96A-2q7vA:
25.30
5o96B-2q7vA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 117
ILE A  14
GLY A  15
GLY A  20
LEU A 279
 None
None
FAD  A 348 (-3.3A)
None
None
 0.91A 5twjA-2q7vA:
undetectable		 5twjA-2q7vA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		5 / 10 GLY A  15
GLY A  17
GLU A  38
THR A 119
ASN A 250
 FAD  A 348 (-3.3A)
FAD  A 348 (-3.4A)
FAD  A 348 (-2.7A)
FAD  A 348 (-3.8A)
FAD  A 348 ( 4.1A)
 0.71A 6exiA-2q7vA:
3.7		 6exiA-2q7vA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		5 / 10 GLY A  15
GLY A  17
GLU A  38
THR A 119
ASN A 250
 FAD  A 348 (-3.3A)
FAD  A 348 (-3.4A)
FAD  A 348 (-2.7A)
FAD  A 348 (-3.8A)
FAD  A 348 ( 4.1A)
 0.75A 6exiB-2q7vA:
3.0		 6exiB-2q7vA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		5 / 12 GLY A  15
GLY A  17
GLU A  38
THR A 119
ASN A 250
 FAD  A 348 (-3.3A)
FAD  A 348 (-3.4A)
FAD  A 348 (-2.7A)
FAD  A 348 (-3.8A)
FAD  A 348 ( 4.1A)
 0.73A 6exiC-2q7vA:
3.8
6exiD-2q7vA:
3.8		 6exiC-2q7vA:
13.49
6exiD-2q7vA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		5 / 12 GLY A  15
GLY A  17
GLU A  38
THR A 119
ASN A 250
 FAD  A 348 (-3.3A)
FAD  A 348 (-3.4A)
FAD  A 348 (-2.7A)
FAD  A 348 (-3.8A)
FAD  A 348 ( 4.1A)
 0.73A 6exiC-2q7vA:
3.8
6exiD-2q7vA:
3.8		 6exiC-2q7vA:
13.49
6exiD-2q7vA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		5 / 11 ALA A  23
ALA A 282
ALA A 303
GLY A  16
GLY A  15
 None
None
None
FAD  A 348 ( 4.9A)
FAD  A 348 (-3.3A)
 0.92A 6hwdK-2q7vA:
undetectable
6hwdL-2q7vA:
undetectable		 6hwdK-2q7vA:
13.19
6hwdL-2q7vA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2q7v THIOREDOXIN
REDUCTASE
(Deinococcus
radiodurans) 		5 / 11 ALA A  23
ALA A 282
ALA A 303
GLY A  16
GLY A  15
 None
None
None
FAD  A 348 ( 4.9A)
FAD  A 348 (-3.3A)
 0.93A 6hwdY-2q7vA:
undetectable
6hwdZ-2q7vA:
undetectable		 6hwdY-2q7vA:
13.19
6hwdZ-2q7vA:
12.00