SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q7x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		5 / 9 LEU A 317
LEU A 256
ILE A 252
THR A   7
ILE A 187
 None
 1.39A 1hzeA-2q7xA:
undetectable
1hzeB-2q7xA:
undetectable		 1hzeA-2q7xA:
17.21
1hzeB-2q7xA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		5 / 9 THR A   7
ILE A 187
LEU A 317
LEU A 256
ILE A 252
 None
 1.39A 1hzeA-2q7xA:
undetectable
1hzeB-2q7xA:
undetectable		 1hzeA-2q7xA:
17.21
1hzeB-2q7xA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		5 / 10 LEU A 317
LEU A 256
ILE A 252
THR A   7
ILE A 187
 None
 1.43A 1i18A-2q7xA:
undetectable
1i18B-2q7xA:
undetectable		 1i18A-2q7xA:
17.21
1i18B-2q7xA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		5 / 10 THR A   7
ILE A 187
LEU A 317
LEU A 256
ILE A 252
 None
 1.43A 1i18A-2q7xA:
undetectable
1i18B-2q7xA:
undetectable		 1i18A-2q7xA:
17.21
1i18B-2q7xA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		4 / 6 PHE A 138
GLY A 229
SER A 193
THR A 196
 None
 0.97A 1kqbC-2q7xA:
undetectable
1kqbD-2q7xA:
undetectable		 1kqbC-2q7xA:
20.99
1kqbD-2q7xA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		5 / 12 ARG A 300
GLY A 192
PRO A  16
VAL A  17
ILE A  18
 None
 1.07A 1sduB-2q7xA:
undetectable		 1sduB-2q7xA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		5 / 11 GLY A 192
PRO A 191
TYR A 220
ILE A 224
HIS A 239
 None
None
None
CL  A 326 (-4.4A)
None
 1.29A 1tmxA-2q7xA:
undetectable		 1tmxA-2q7xA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		5 / 12 GLY A 192
PRO A 191
TYR A 220
ILE A 224
HIS A 239
 None
None
None
CL  A 326 (-4.4A)
None
 1.22A 1tmxB-2q7xA:
undetectable		 1tmxB-2q7xA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		3 / 3 HIS A 233
ASP A 236
ASN A 258
 None
 0.79A 1wg8B-2q7xA:
3.8		 1wg8B-2q7xA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		5 / 9 ARG A 300
GLY A 192
PRO A  16
VAL A  17
ILE A  18
 None
 1.11A 2avoA-2q7xA:
undetectable		 2avoA-2q7xA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		3 / 3 ASP A 282
VAL A 240
PRO A 250
 None
 0.75A 2avvA-2q7xA:
undetectable		 2avvA-2q7xA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		3 / 3 ILE A 218
ILE A   9
LEU A 286
 None
 0.51A 2prgA-2q7xA:
undetectable		 2prgA-2q7xA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		5 / 10 THR A 180
ILE A 187
LEU A 189
GLY A  10
THR A   7
 None
 1.28A 2wd9C-2q7xA:
4.5		 2wd9C-2q7xA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		5 / 12 ILE A 218
ALA A 110
THR A 107
LEU A  58
MET A  65
 None
None
None
None
MLY  A 123 ( 4.5A)
 1.14A 2x2nD-2q7xA:
undetectable		 2x2nD-2q7xA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		5 / 12 ILE A 207
GLY A 192
LEU A 243
ILE A 313
ILE A  18
 None
 1.05A 3pwwA-2q7xA:
undetectable		 3pwwA-2q7xA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		4 / 8 THR A 133
PRO A 131
GLY A  40
SER A 106
 None
 1.01A 3tzfB-2q7xA:
undetectable		 3tzfB-2q7xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		5 / 10 ARG A 300
GLY A 192
PRO A  16
VAL A  17
ILE A  18
 None
 1.12A 4dqcA-2q7xA:
undetectable		 4dqcA-2q7xA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		3 / 3 ARG A 292
GLU A 316
PHE A 298
 None
 1.02A 4kszA-2q7xA:
undetectable		 4kszA-2q7xA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		5 / 11 ILE A  18
THR A  13
SER A  15
GLY A  14
ARG A 300
 None
 1.49A 4xt7A-2q7xA:
3.7		 4xt7A-2q7xA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		5 / 9 ILE A 218
ALA A 219
ILE A 252
ILE A 198
LEU A 243
 None
 1.13A 5mvmA-2q7xA:
undetectable
5mvmE-2q7xA:
undetectable		 5mvmA-2q7xA:
12.08
5mvmE-2q7xA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		4 / 8 GLY A 208
LEU A 211
GLU A 206
ALA A 210
 MLY  A 205 ( 3.6A)
None
None
None
 0.75A 5vw5A-2q7xA:
undetectable		 5vw5A-2q7xA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		5 / 12 LEU A 189
LEU A 247
ALA A 210
ILE A 207
ILE A 181
 None
 1.13A 5xiwD-2q7xA:
4.8		 5xiwD-2q7xA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		3 / 3 ASN A  60
VAL A 221
HIS A 308
 None
 0.70A 6a5yD-2q7xA:
undetectable		 6a5yD-2q7xA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2q7x UPF0052 PROTEIN
SP_1565
(Streptococcus
pneumoniae) 		3 / 3 TYR A 108
ALA A 165
LEU A 166
 None
 0.46A 6ag0C-2q7xA:
undetectable		 6ag0C-2q7xA:
14.81