SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q8h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		4 / 8 ASP A 318
TYR A 233
ARG A 237
THR A 288
 None
 1.43A 1ceaA-2q8hA:
undetectable
1ceaB-2q8hA:
undetectable		 1ceaA-2q8hA:
11.19
1ceaB-2q8hA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		4 / 5 LEU A  83
SER A  75
LEU A  57
LEU A 195
 None
 1.09A 1yajD-2q8hA:
undetectable		 1yajD-2q8hA:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		5 / 8 LEU A  87
TYR A 114
ARG A 188
ILE A 191
ARG A 192
 None
TF4  A 438 (-3.8A)
TF4  A 438 (-4.2A)
TF4  A 438 (-3.4A)
TF4  A 438 ( 4.8A)
 0.82A 2bu8A-2q8hA:
46.0		 2bu8A-2q8hA:
68.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		5 / 8 LEU A  87
TYR A 114
ILE A 145
ARG A 188
ILE A 191
 None
TF4  A 438 (-3.8A)
None
TF4  A 438 (-4.2A)
TF4  A 438 (-3.4A)
 0.61A 2bu8A-2q8hA:
46.0		 2bu8A-2q8hA:
68.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		5 / 12 ILE A 301
ALA A 236
ARG A 237
LEU A 250
LEU A 273
 None
 1.32A 2rctA-2q8hA:
undetectable		 2rctA-2q8hA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		4 / 8 LEU A  83
ILE A 191
LEU A 195
LEU A 121
 None
TF4  A 438 (-3.4A)
None
None
 0.76A 2xfhA-2q8hA:
undetectable		 2xfhA-2q8hA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		4 / 4 GLY A 320
GLY A 322
GLY A 380
GLY A 382
 None
 0.64A 3bogD-2q8hA:
undetectable		 3bogD-2q8hA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		4 / 6 GLN A  81
LEU A  79
GLU A  82
LEU A 194
 None
 0.93A 3h5gA-2q8hA:
undetectable
3h5gC-2q8hA:
undetectable		 3h5gA-2q8hA:
7.46
3h5gC-2q8hA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		5 / 12 LEU A 239
HIS A 275
GLY A 358
SER A 362
LEU A 352
 None
 1.32A 3okxB-2q8hA:
undetectable		 3okxB-2q8hA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		5 / 10 LEU A 373
VAL A 314
ILE A 229
GLY A 232
ILE A 387
 None
 1.04A 3oxwB-2q8hA:
undetectable		 3oxwB-2q8hA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		4 / 7 LEU A 312
LEU A 307
PRO A 263
ILE A 264
 None
 0.96A 3s56B-2q8hA:
undetectable		 3s56B-2q8hA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		5 / 12 LEU A  83
ALA A 129
LEU A 200
PHE A 202
THR A 139
 None
 1.42A 4iaqA-2q8hA:
2.3		 4iaqA-2q8hA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		4 / 8 VAL A 177
LEU A 181
TYR A 357
ILE A 361
 None
 0.94A 4ma7A-2q8hA:
undetectable		 4ma7A-2q8hA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		5 / 11 LEU A 373
VAL A 314
ILE A 229
GLY A 232
ILE A 387
 None
 0.94A 4rvjA-2q8hA:
undetectable		 4rvjA-2q8hA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		5 / 11 LEU A 373
VAL A 314
ILE A 229
GLY A 232
ILE A 387
 None
 0.96A 4rvjC-2q8hA:
undetectable		 4rvjC-2q8hA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		4 / 5 THR A 288
HIS A 291
ALA A 287
ASP A 318
 None
 1.44A 5mfxA-2q8hA:
undetectable		 5mfxA-2q8hA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		4 / 6 ILE A 397
ILE A 191
LEU A 194
PHE A  62
 None
TF4  A 438 (-3.4A)
None
None
 1.07A 5vkqA-2q8hA:
undetectable
5vkqB-2q8hA:
undetectable		 5vkqA-2q8hA:
12.68
5vkqB-2q8hA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1
(Homo
sapiens) 		4 / 6 ILE A 397
ILE A 191
LEU A 194
PHE A  62
 None
TF4  A 438 (-3.4A)
None
None
 1.05A 5vkqA-2q8hA:
undetectable
5vkqD-2q8hA:
undetectable		 5vkqA-2q8hA:
12.68
5vkqD-2q8hA:
12.68