SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q8n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 11 VAL A 205
GLY A 206
VAL A 109
ASP A 111
VAL A  71
 None
 0.87A 1akdA-2q8nA:
undetectable		 1akdA-2q8nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 9 VAL A 201
VAL A 390
ALA A  83
SER A  87
LEU A  84
 None
 1.21A 1eqgA-2q8nA:
undetectable		 1eqgA-2q8nA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 11 PRO A 192
ASN A  81
GLY A  80
TRP A  52
LEU A 207
 None
 1.10A 1fkpA-2q8nA:
undetectable		 1fkpA-2q8nA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		4 / 8 VAL A 205
VAL A 109
ASP A 111
VAL A  71
 None
 0.90A 1iwiA-2q8nA:
undetectable		 1iwiA-2q8nA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 11 VAL A 205
GLY A 206
VAL A 109
ASP A 111
VAL A  71
 None
 0.86A 1phgA-2q8nA:
undetectable		 1phgA-2q8nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 10 PHE A 393
LEU A 385
VAL A 330
PHE A 382
VAL A 390
 None
 1.42A 1q23E-2q8nA:
undetectable		 1q23E-2q8nA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		6 / 12 PHE A 393
LEU A 385
VAL A 330
PHE A 382
VAL A 390
ALA A 263
 None
 1.36A 1q23H-2q8nA:
undetectable
1q23I-2q8nA:
undetectable		 1q23H-2q8nA:
16.02
1q23I-2q8nA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 11 VAL A 205
GLY A 206
VAL A 109
ASP A 111
VAL A  71
 None
 0.97A 2a1nA-2q8nA:
undetectable		 2a1nA-2q8nA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		4 / 8 SER A  58
LEU A  59
LEU A 189
ASP A  54
 None
 1.00A 2j2pA-2q8nA:
undetectable
2j2pB-2q8nA:
undetectable		 2j2pA-2q8nA:
19.23
2j2pB-2q8nA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		4 / 5 VAL A 201
THR A 203
VAL A 195
GLY A 196
 None
 1.10A 2p2fA-2q8nA:
3.7		 2p2fA-2q8nA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		4 / 4 VAL A 201
THR A 203
VAL A 195
GLY A 196
 None
 1.13A 2p2fB-2q8nA:
2.8		 2p2fB-2q8nA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		4 / 4 GLU A 362
GLY A 365
THR A 366
GLU A 367
 None
 1.21A 3e9xA-2q8nA:
undetectable		 3e9xA-2q8nA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 ALA A  83
GLU A 398
LEU A 220
GLY A 391
PHE A 394
 None
 1.04A 3k2hA-2q8nA:
undetectable		 3k2hA-2q8nA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 ALA A  83
GLU A 398
LEU A 220
GLY A 391
PHE A 394
 None
 1.02A 3k2hB-2q8nA:
undetectable		 3k2hB-2q8nA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		3 / 3 PHE A 403
TYR A 396
LEU A 252
 None
 0.73A 3keeB-2q8nA:
undetectable		 3keeB-2q8nA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 ALA A  83
GLU A 398
LEU A 220
GLY A 391
PHE A 394
 None
 1.09A 3nrrA-2q8nA:
undetectable		 3nrrA-2q8nA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 ALA A  83
GLU A 398
LEU A 220
GLY A 391
PHE A 394
 None
 1.09A 3nrrB-2q8nA:
undetectable		 3nrrB-2q8nA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 TYR A 397
ALA A  83
ALA A 263
ASP A 273
VAL A 272
 None
 1.25A 3nvkF-2q8nA:
1.0
3nvkJ-2q8nA:
undetectable		 3nvkF-2q8nA:
24.59
3nvkJ-2q8nA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		4 / 7 LEU A 358
LEU A 355
PRO A 340
ILE A 339
 None
 0.91A 3s56B-2q8nA:
undetectable		 3s56B-2q8nA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		3 / 3 PHE A 403
TYR A 396
LEU A 252
 None
 0.73A 3sueB-2q8nA:
undetectable		 3sueB-2q8nA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 GLY A  78
GLY A  76
ILE A  74
VAL A  70
ILE A 135
 None
 1.07A 4fglA-2q8nA:
2.4
4fglB-2q8nA:
2.1		 4fglA-2q8nA:
19.57
4fglB-2q8nA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 MET A 118
VAL A 121
LEU A 122
LEU A  72
TRP A  62
 None
 1.01A 4o1zB-2q8nA:
undetectable		 4o1zB-2q8nA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		4 / 8 TRP A 274
ALA A  83
LEU A  84
GLY A 206
 None
 0.80A 4xk8a-2q8nA:
undetectable		 4xk8a-2q8nA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_A_RAUA400_1
(IMINE REDUCTASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 11 LEU A 283
MET A 404
SER A 259
GLN A 298
GLY A 297
 None
 1.44A 5g6sA-2q8nA:
2.1
5g6sG-2q8nA:
1.5		 5g6sA-2q8nA:
19.40
5g6sG-2q8nA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_B_RAUB400_1
(IMINE REDUCTASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 11 LEU A 283
MET A 404
SER A 259
GLN A 298
GLY A 297
 None
 1.44A 5g6sB-2q8nA:
2.1
5g6sC-2q8nA:
2.1		 5g6sB-2q8nA:
19.40
5g6sC-2q8nA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 SER A 259
GLN A 298
GLY A 297
LEU A 283
MET A 404
 None
 1.45A 5g6sB-2q8nA:
2.1
5g6sC-2q8nA:
2.1		 5g6sB-2q8nA:
19.40
5g6sC-2q8nA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_E_RAUE400_1
(IMINE REDUCTASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 11 LEU A 283
MET A 404
SER A 259
GLN A 298
GLY A 297
 None
 1.45A 5g6sE-2q8nA:
2.1
5g6sH-2q8nA:
2.1		 5g6sE-2q8nA:
19.40
5g6sH-2q8nA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_F_RAUF400_1
(IMINE REDUCTASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 10 SER A 259
GLN A 298
GLY A 297
LEU A 283
MET A 404
 None
 1.45A 5g6sD-2q8nA:
1.5
5g6sF-2q8nA:
1.5		 5g6sD-2q8nA:
19.40
5g6sF-2q8nA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_G_RAUG400_1
(IMINE REDUCTASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 10 SER A 259
GLN A 298
GLY A 297
LEU A 283
MET A 404
 None
 1.44A 5g6sA-2q8nA:
2.1
5g6sG-2q8nA:
1.5		 5g6sA-2q8nA:
19.40
5g6sG-2q8nA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		3 / 3 GLY A 196
GLY A 197
GLN A 415
 None
 0.31A 5imsA-2q8nA:
2.4		 5imsA-2q8nA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		3 / 3 GLY A 196
GLN A 415
LYS A 137
 None
 0.93A 5imsB-2q8nA:
2.7		 5imsB-2q8nA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		3 / 3 GLU A 293
ARG A 286
TYR A 287
 None
 0.40A 5trqB-2q8nA:
undetectable		 5trqB-2q8nA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 PRO A 300
SER A 259
LEU A 283
GLY A 284
GLY A 297
 None
 0.94A 5wyqB-2q8nA:
undetectable		 5wyqB-2q8nA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 ALA A  83
LEU A  84
VAL A 109
ASP A 111
GLY A  73
 None
 1.19A 5x24A-2q8nA:
undetectable		 5x24A-2q8nA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 PHE A 199
ALA A 241
ALA A 245
LEU A 283
LEU A 278
 None
 1.21A 6aybA-2q8nA:
undetectable		 6aybA-2q8nA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 LEU A  88
ASP A 216
LEU A 220
ALA A 224
LEU A   3
 None
 1.03A 6b0iB-2q8nA:
3.2		 6b0iB-2q8nA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 LEU A  88
ILE A 215
LEU A 207
GLY A 206
ASN A  81
 None
 1.13A 6qxsD-2q8nA:
undetectable		 6qxsD-2q8nA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermotoga
maritima) 		5 / 12 LEU A  88
ILE A 215
LEU A 207
GLY A 206
ASN A  81
 None
 1.13A 6qyaD-2q8nA:
undetectable		 6qyaD-2q8nA:
22.41