SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2q8q IRON-REGULATED
SURFACE DETERMINANT
E
(Staphylococcus
aureus) 		3 / 3 ASN A 246
TRP A 249
GLN A 245
 None
 1.14A 1xoqA-2q8qA:
undetectable		 1xoqA-2q8qA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2q8q IRON-REGULATED
SURFACE DETERMINANT
E
(Staphylococcus
aureus) 		5 / 9 LEU A 227
LEU A 263
PHE A 268
LEU A 191
ILE A 188
 None
 1.25A 2f7aA-2q8qA:
undetectable		 2f7aA-2q8qA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 2q8q IRON-REGULATED
SURFACE DETERMINANT
E
(Staphylococcus
aureus) 		4 / 6 THR A  40
VAL A  41
GLU A 265
SER A  60
 HEM  A 300 (-4.0A)
HEM  A 300 (-3.5A)
None
HEM  A 300 (-2.7A)
 1.15A 3b6rB-2q8qA:
undetectable		 3b6rB-2q8qA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2q8q IRON-REGULATED
SURFACE DETERMINANT
E
(Staphylococcus
aureus) 		4 / 8 LYS A 278
ASP A 277
LEU A 149
ASN A 273
 None
 0.96A 3lm8A-2q8qA:
3.7
3lm8C-2q8qA:
3.2		 3lm8A-2q8qA:
20.66
3lm8C-2q8qA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2q8q IRON-REGULATED
SURFACE DETERMINANT
E
(Staphylococcus
aureus) 		5 / 12 ILE A 171
VAL A 169
LEU A 225
ALA A 195
LEU A 191
 None
 0.98A 4m11B-2q8qA:
undetectable		 4m11B-2q8qA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2q8q IRON-REGULATED
SURFACE DETERMINANT
E
(Staphylococcus
aureus) 		4 / 7 LEU A 145
LEU A 149
ALA A 276
ALA A 272
 None
 0.63A 4z90F-2q8qA:
undetectable
4z90G-2q8qA:
undetectable
4z90H-2q8qA:
undetectable
4z90J-2q8qA:
undetectable		 4z90F-2q8qA:
22.39
4z90G-2q8qA:
22.39
4z90H-2q8qA:
22.39
4z90J-2q8qA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2q8q IRON-REGULATED
SURFACE DETERMINANT
E
(Staphylococcus
aureus) 		3 / 3 THR A 271
HIS A  92
LEU A 132
 HEM  A 300 (-4.3A)
None
None
 0.83A 5axdA-2q8qA:
3.7		 5axdA-2q8qA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2q8q IRON-REGULATED
SURFACE DETERMINANT
E
(Staphylococcus
aureus) 		3 / 3 THR A 271
HIS A  92
LEU A 132
 HEM  A 300 (-4.3A)
None
None
 0.82A 5axdC-2q8qA:
undetectable		 5axdC-2q8qA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 2q8q IRON-REGULATED
SURFACE DETERMINANT
E
(Staphylococcus
aureus) 		4 / 6 ASN A 199
PRO A 167
VAL A 169
ASP A 184
 None
 1.18A 5umd2-2q8qA:
undetectable
5umdF-2q8qA:
undetectable		 5umd2-2q8qA:
18.70
5umdF-2q8qA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2q8q IRON-REGULATED
SURFACE DETERMINANT
E
(Staphylococcus
aureus) 		4 / 7 PHE A 136
ARG A 138
LEU A 132
GLN A 141
 None
 1.17A 6b89A-2q8qA:
undetectable		 6b89A-2q8qA:
16.96