SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q8w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		5 / 12 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 1.01A 1fbyA-2q8wA:
undetectable		 1fbyA-2q8wA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		5 / 12 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 1.01A 1fbyB-2q8wA:
undetectable		 1fbyB-2q8wA:
22.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		6 / 9 PHE A  89
GLY A 120
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 None
 0.35A 1mrgA-2q8wA:
30.7		 1mrgA-2q8wA:
30.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		5 / 8 GLY A 120
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 None
 0.25A 1mrjA-2q8wA:
30.5		 1mrjA-2q8wA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		4 / 5 GLU A 205
THR A 124
LEU A 125
LEU A 121
 None
 1.02A 1u18B-2q8wA:
undetectable		 1u18B-2q8wA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		5 / 12 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 0.98A 1xdkA-2q8wA:
undetectable		 1xdkA-2q8wA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		5 / 12 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 0.98A 1xdkE-2q8wA:
undetectable		 1xdkE-2q8wA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		5 / 12 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 0.96A 1xiuA-2q8wA:
undetectable		 1xiuA-2q8wA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		5 / 12 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 1.04A 3dzyA-2q8wA:
undetectable		 3dzyA-2q8wA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		5 / 10 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 1.01A 3falC-2q8wA:
undetectable		 3falC-2q8wA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		5 / 11 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 0.96A 3fc6A-2q8wA:
undetectable		 3fc6A-2q8wA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		5 / 12 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 0.97A 3oapA-2q8wA:
undetectable		 3oapA-2q8wA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		4 / 6 ASN A 197
TYR A 122
GLU A 175
ILE A 182
 None
 0.99A 3q5sA-2q8wA:
undetectable		 3q5sA-2q8wA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		5 / 10 TYR A  72
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 None
 0.67A 3u6tA-2q8wA:
31.0		 3u6tA-2q8wA:
29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		5 / 12 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 0.97A 4nqaH-2q8wA:
undetectable		 4nqaH-2q8wA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		4 / 5 TYR A  72
TYR A 122
ILE A 170
ARG A 178
 None
 0.34A 4o0oA-2q8wA:
31.0		 4o0oA-2q8wA:
29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		5 / 12 THR A  61
ILE A  65
ALA A 169
HIS A  87
ILE A  88
 None
 1.02A 4rvgA-2q8wA:
undetectable		 4rvgA-2q8wA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		3 / 3 GLU A 175
ALA A 176
PHE A 179
 None
 0.67A 4v1fA-2q8wA:
undetectable		 4v1fA-2q8wA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		3 / 3 GLU A 175
ALA A 176
PHE A 179
 None
 0.64A 4v1fC-2q8wA:
undetectable		 4v1fC-2q8wA:
17.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		6 / 9 PHE A  89
GLY A 120
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 None
 0.45A 4yp2B-2q8wA:
31.1		 4yp2B-2q8wA:
31.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		6 / 9 TYR A  72
PHE A  89
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 None
 0.60A 4yp2B-2q8wA:
31.1		 4yp2B-2q8wA:
31.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		6 / 9 PHE A  89
GLY A 120
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 None
 0.41A 5cf9B-2q8wA:
31.2		 5cf9B-2q8wA:
31.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		6 / 9 TYR A  72
PHE A  89
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 None
 0.59A 5cf9B-2q8wA:
31.2		 5cf9B-2q8wA:
31.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		4 / 6 GLU A 175
THR A 124
TYR A 122
TYR A  72
 None
 1.39A 5lrbA-2q8wA:
undetectable		 5lrbA-2q8wA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		5 / 12 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 0.95A 5uanA-2q8wA:
undetectable		 5uanA-2q8wA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		6 / 6 TYR A  72
VAL A  73
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 None
 0.65A 5z3jA-2q8wA:
32.0		 5z3jA-2q8wA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2q8w POKEWEED ANTIVIRAL
PROTEIN
(Phytolacca
acinosa) 		5 / 12 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 0.97A 6a5zL-2q8wA:
undetectable		 6a5zL-2q8wA:
16.09