SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q9g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		4 / 7 VAL A  85
SER A  84
ASP A 105
LYS A 107
 None
 1.35A 1hwiC-2q9gA:
undetectable		 1hwiC-2q9gA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		4 / 7 VAL A  85
SER A  84
ASP A 105
LYS A 107
 None
 1.35A 1hwiD-2q9gA:
undetectable		 1hwiD-2q9gA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		4 / 7 GLU A 200
MET A 203
PHE A 296
ALA A 188
 None
 1.36A 1linA-2q9gA:
undetectable		 1linA-2q9gA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		4 / 6 ASP A 173
GLY A 174
THR A 176
PRO A 177
 None
 0.76A 1n4fA-2q9gA:
undetectable		 1n4fA-2q9gA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		3 / 3 LEU A 476
TYR A 396
GLY A 399
 None
 0.63A 2ocuA-2q9gA:
undetectable		 2ocuA-2q9gA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		5 / 12 PHE A 300
ALA A 193
THR A 185
TYR A 186
LEU A 219
 None
None
None
GOL  A 601 ( 4.5A)
None
 1.33A 2rctA-2q9gA:
undetectable		 2rctA-2q9gA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		5 / 12 THR A 298
PHE A 299
ILE A 141
ASP A 142
TRP A 134
 None
HEM  A 505 (-4.0A)
None
None
HEM  A 505 (-3.7A)
 1.19A 2v95A-2q9gA:
undetectable		 2v95A-2q9gA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		4 / 8 TYR A 109
PHE A 121
ALA A 302
THR A 306
 None
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
 0.83A 2wx2B-2q9gA:
34.2		 2wx2B-2q9gA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		3 / 3 LEU A 120
VAL A 253
ARG A 251
 None
 0.84A 3b0wB-2q9gA:
undetectable		 3b0wB-2q9gA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		3 / 3 ALA A 302
THR A 306
CYH A 437
 HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-2.3A)
 0.46A 3e4eA-2q9gA:
34.9		 3e4eA-2q9gA:
27.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		3 / 3 ALA A 302
THR A 306
CYH A 437
 HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-2.3A)
 0.33A 3e4eB-2q9gA:
34.8		 3e4eB-2q9gA:
27.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		6 / 6 LEU A 112
PHE A 121
ILE A 301
ALA A 302
THR A 306
THR A 475
 None
None
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
None
 0.60A 3mdrA-2q9gA:
65.8		 3mdrA-2q9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		6 / 6 PHE A 121
ILE A 301
ALA A 302
THR A 306
ALA A 367
THR A 475
 None
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
None
 0.52A 3mdrB-2q9gA:
65.9		 3mdrB-2q9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		8 / 9 LEU A 112
PHE A 121
VAL A 126
ILE A 301
ALA A 302
THR A 306
ALA A 367
THR A 475
 None
None
HEM  A 505 ( 3.8A)
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
None
 0.59A 3mdtA-2q9gA:
65.4		 3mdtA-2q9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		8 / 9 PHE A 121
VAL A 126
SER A 127
ILE A 301
ALA A 302
THR A 306
ALA A 367
THR A 475
 None
HEM  A 505 ( 3.8A)
None
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
None
 0.40A 3mdtA-2q9gA:
65.4		 3mdtA-2q9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		10 / 11 TYR A 109
LEU A 112
PHE A 121
VAL A 126
ILE A 222
ALA A 302
THR A 306
ALA A 367
ALA A 474
THR A 475
 None
None
None
HEM  A 505 ( 3.8A)
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
None
None
 0.47A 3mdtB-2q9gA:
65.5		 3mdtB-2q9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		10 / 11 TYR A 109
PHE A 121
VAL A 126
SER A 127
ILE A 222
ALA A 302
THR A 306
ALA A 367
ALA A 474
THR A 475
 None
None
HEM  A 505 ( 3.8A)
None
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
None
None
 0.42A 3mdtB-2q9gA:
65.5		 3mdtB-2q9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		9 / 9 LEU A 112
PHE A 121
VAL A 126
LEU A 219
ILE A 301
ALA A 302
GLU A 305
ALA A 474
THR A 475
 None
None
HEM  A 505 ( 3.8A)
None
None
HEM  A 505 (-3.7A)
None
None
None
 0.42A 3mdvA-2q9gA:
66.1		 3mdvA-2q9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		12 / 12 LEU A 112
PHE A 121
VAL A 126
LEU A 219
THR A 298
ILE A 301
ALA A 302
GLU A 305
THR A 306
ALA A 367
ALA A 474
THR A 475
 None
None
HEM  A 505 ( 3.8A)
None
None
None
HEM  A 505 (-3.7A)
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
None
None
 0.39A 3mdvB-2q9gA:
66.1		 3mdvB-2q9gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		3 / 3 PHE A 296
ASP A 294
ARG A 251
 None
 0.78A 4eahF-2q9gA:
undetectable		 4eahF-2q9gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		3 / 3 PHE A 296
ASP A 294
ARG A 251
 None
 0.78A 4eahG-2q9gA:
undetectable		 4eahG-2q9gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		4 / 6 PHE A 296
ALA A 193
THR A 201
LEU A 211
 None
 0.97A 4ejgD-2q9gA:
35.0		 4ejgD-2q9gA:
26.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		12 / 12 PHE A  80
PHE A 121
LEU A 219
ILE A 222
ILE A 301
ALA A 302
THR A 306
ALA A 367
TRP A 368
GLY A 369
ALA A 474
THR A 475
 None
None
None
None
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
None
None
None
None
 0.38A 4enhA-2q9gA:
66.8		 4enhA-2q9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		9 / 12 PHE A  80
TYR A 109
LEU A 112
PHE A 121
VAL A 126
ALA A 302
THR A 306
ALA A 474
THR A 475
 None
None
None
None
HEM  A 505 ( 3.8A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
None
None
 0.87A 4fiaA-2q9gA:
65.8		 4fiaA-2q9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		7 / 12 PHE A  80
TYR A 109
VAL A 126
THR A 306
GLU A 472
ALA A 474
THR A 475
 None
None
HEM  A 505 ( 3.8A)
HEM  A 505 (-3.7A)
None
None
None
 0.86A 4fiaA-2q9gA:
65.8		 4fiaA-2q9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		9 / 12 TYR A 109
LEU A 112
PHE A 121
VAL A 126
ALA A 302
THR A 306
TRP A 368
ALA A 474
THR A 475
 None
None
None
HEM  A 505 ( 3.8A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
None
None
None
 0.67A 4fiaA-2q9gA:
65.8		 4fiaA-2q9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		7 / 12 TYR A 109
VAL A 126
THR A 306
TRP A 368
GLU A 472
ALA A 474
THR A 475
 None
HEM  A 505 ( 3.8A)
HEM  A 505 (-3.7A)
None
None
None
None
 0.77A 4fiaA-2q9gA:
65.8		 4fiaA-2q9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		9 / 12 PHE A  80
TYR A 109
LEU A 112
PHE A 121
VAL A 126
ALA A 302
THR A 306
ALA A 474
THR A 475
 None
None
None
None
HEM  A 505 ( 3.8A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
None
None
 0.87A 4fiaA-2q9gA:
65.8		 4fiaA-2q9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		7 / 12 PHE A  80
TYR A 109
VAL A 126
THR A 306
GLU A 472
ALA A 474
THR A 475
 None
None
HEM  A 505 ( 3.8A)
HEM  A 505 (-3.7A)
None
None
None
 0.86A 4fiaA-2q9gA:
65.8		 4fiaA-2q9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		9 / 12 TYR A 109
LEU A 112
PHE A 121
VAL A 126
ALA A 302
THR A 306
TRP A 368
ALA A 474
THR A 475
 None
None
None
HEM  A 505 ( 3.8A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
None
None
None
 0.67A 4fiaA-2q9gA:
65.8		 4fiaA-2q9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		7 / 12 TYR A 109
VAL A 126
THR A 306
TRP A 368
GLU A 472
ALA A 474
THR A 475
 None
HEM  A 505 ( 3.8A)
HEM  A 505 (-3.7A)
None
None
None
None
 0.77A 4fiaA-2q9gA:
65.8		 4fiaA-2q9gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		9 / 10 ALA A 111
LEU A 112
PHE A 121
VAL A 126
ILE A 301
ALA A 302
THR A 306
ALA A 367
THR A 475
 None
None
None
HEM  A 505 ( 3.8A)
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
None
 0.59A 4j14A-2q9gA:
63.4		 4j14A-2q9gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		4 / 4 HIS A 310
GLU A 305
HIS A 304
LEU A 204
 HEM  A 505 ( 4.6A)
None
None
None
 1.01A 4m2rA-2q9gA:
undetectable		 4m2rA-2q9gA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		4 / 8 LEU A 125
GLY A 124
GLU A 128
ALA A 286
 HEM  A 505 (-4.1A)
None
None
None
 0.88A 4rjdA-2q9gA:
undetectable
4rjdB-2q9gA:
undetectable		 4rjdA-2q9gA:
9.75
4rjdB-2q9gA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		5 / 6 LEU A 219
ILE A 301
ALA A 302
THR A 306
ALA A 367
 None
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
 0.83A 4zf8A-2q9gA:
43.4		 4zf8A-2q9gA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		5 / 6 VAL A 126
ILE A 301
ALA A 302
THR A 306
ALA A 367
 HEM  A 505 ( 3.8A)
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
 0.49A 4zf8A-2q9gA:
43.4		 4zf8A-2q9gA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		4 / 6 TYR A 109
THR A 370
ARG A 372
ASP A 105
 None
HEM  A 505 (-2.9A)
HEM  A 505 ( 4.0A)
None
 1.21A 5mraA-2q9gA:
undetectable
5mraB-2q9gA:
0.7		 5mraA-2q9gA:
16.67
5mraB-2q9gA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		5 / 9 LEU A 192
ILE A 275
ILE A 279
ASN A 295
PHE A 296
 None
 0.99A 5nunA-2q9gA:
undetectable		 5nunA-2q9gA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		4 / 8 GLY A 124
LEU A 125
GLN A 137
ALA A 282
 None
HEM  A 505 (-4.1A)
None
None
 0.86A 5xu8A-2q9gA:
undetectable		 5xu8A-2q9gA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		4 / 5 HIS A 310
GLU A 305
HIS A 304
LEU A 204
 HEM  A 505 ( 4.6A)
None
None
None
 1.01A 6bc9A-2q9gA:
undetectable		 6bc9A-2q9gA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		4 / 7 ALA A 188
THR A 187
TYR A 186
PRO A 478
 None
None
GOL  A 601 ( 4.5A)
None
 0.70A 6cduA-2q9gA:
undetectable
6cduE-2q9gA:
undetectable		 6cduA-2q9gA:
23.11
6cduE-2q9gA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		4 / 8 PRO A 478
ALA A 188
THR A 187
TYR A 186
 None
None
None
GOL  A 601 ( 4.5A)
 0.72A 6cduD-2q9gA:
1.1
6cduE-2q9gA:
1.1		 6cduD-2q9gA:
23.11
6cduE-2q9gA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		4 / 7 PRO A 478
ALA A 188
THR A 187
TYR A 186
 None
None
None
GOL  A 601 ( 4.5A)
 0.76A 6cduH-2q9gA:
1.5
6cduI-2q9gA:
undetectable		 6cduH-2q9gA:
23.11
6cduI-2q9gA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		6 / 10 PHE A 121
VAL A 126
ILE A 301
ALA A 302
THR A 306
ALA A 367
 None
HEM  A 505 ( 3.8A)
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
 0.41A 6h1lA-2q9gA:
42.3		 6h1lA-2q9gA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2q9g CYTOCHROME P450 46A1
(Homo
sapiens) 		6 / 11 PHE A 121
VAL A 126
ILE A 301
ALA A 302
THR A 306
ALA A 367
 None
HEM  A 505 ( 3.8A)
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
 0.40A 6h1lB-2q9gA:
41.9		 6h1lB-2q9gA:
26.28