SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2q9t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2q9t DING
(Pseudomonas
fluorescens) 		5 / 8 ARG A 153
LEU A 150
ASP A  62
ALA A   7
GLY A  33
 None
None
PO4  A 901 (-2.8A)
PO4  A 901 (-3.3A)
None
 1.44A 1d4sB-2q9tA:
undetectable		 1d4sB-2q9tA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2q9t DING
(Pseudomonas
fluorescens) 		4 / 4 SER A  89
VAL A 344
PHE A 313
VAL A  19
 None
 1.39A 1o86A-2q9tA:
undetectable		 1o86A-2q9tA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 2q9t DING
(Pseudomonas
fluorescens) 		4 / 7 ASP A 312
THR A  21
ILE A   2
PHE A 297
 None
 1.19A 2jc9A-2q9tA:
undetectable		 2jc9A-2q9tA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2q9t DING
(Pseudomonas
fluorescens) 		3 / 3 LEU A 155
LEU A 180
PHE A 151
 None
 0.71A 2pgrA-2q9tA:
undetectable		 2pgrA-2q9tA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2q9t DING
(Pseudomonas
fluorescens) 		3 / 3 PRO A  10
GLY A  60
TYR A  27
 None
 0.74A 2vouA-2q9tA:
undetectable		 2vouA-2q9tA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2q9t DING
(Pseudomonas
fluorescens) 		3 / 3 PRO A  10
GLY A  60
TYR A  27
 None
 0.73A 2vouB-2q9tA:
undetectable		 2vouB-2q9tA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2q9t DING
(Pseudomonas
fluorescens) 		3 / 3 PRO A  10
GLY A  60
TYR A  27
 None
 0.73A 2vouC-2q9tA:
undetectable		 2vouC-2q9tA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 2q9t DING
(Pseudomonas
fluorescens) 		5 / 10 GLU A 162
VAL A 185
ALA A 186
PHE A 172
PHE A 151
 None
EDO  A 906 ( 4.1A)
EDO  A 906 (-3.4A)
None
None
 1.38A 3a3yA-2q9tA:
undetectable		 3a3yA-2q9tA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 2q9t DING
(Pseudomonas
fluorescens) 		5 / 12 GLY A 102
GLY A 131
VAL A 116
PHE A 117
ILE A 204
 None
 0.87A 3eluA-2q9tA:
undetectable		 3eluA-2q9tA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 2q9t DING
(Pseudomonas
fluorescens) 		5 / 12 LEU A 108
ASP A 107
VAL A 106
GLY A 238
TYR A 287
 None
EDO  A 910 (-3.6A)
None
None
None
 1.42A 3hgiA-2q9tA:
undetectable		 3hgiA-2q9tA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2q9t DING
(Pseudomonas
fluorescens) 		3 / 3 SER A 145
GLY A 146
THR A 147
 PO4  A 901 (-2.6A)
PO4  A 901 (-3.6A)
PO4  A 901 (-3.6A)
 0.07A 3k9wA-2q9tA:
undetectable		 3k9wA-2q9tA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2q9t DING
(Pseudomonas
fluorescens) 		3 / 3 ASP A 220
VAL A 106
ASN A 245
 None
 0.64A 4lmnA-2q9tA:
undetectable		 4lmnA-2q9tA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2q9t DING
(Pseudomonas
fluorescens) 		4 / 7 VAL A 116
ILE A 204
ILE A  96
ALA A 226
 None
 0.81A 4lv9A-2q9tA:
undetectable		 4lv9A-2q9tA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 2q9t DING
(Pseudomonas
fluorescens) 		4 / 6 ALA A 226
LEU A 108
LYS A 230
SER A 128
 None
 1.06A 4ot2A-2q9tA:
undetectable		 4ot2A-2q9tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2q9t DING
(Pseudomonas
fluorescens) 		5 / 12 GLY A 179
GLY A 178
PHE A 117
ILE A 136
ASN A 122
 None
 0.97A 4rtmA-2q9tA:
undetectable		 4rtmA-2q9tA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2q9t DING
(Pseudomonas
fluorescens) 		5 / 12 GLY A 319
TYR A  14
LEU A  20
TYR A  27
THR A 315
 None
 1.11A 5eskA-2q9tA:
undetectable		 5eskA-2q9tA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2q9t DING
(Pseudomonas
fluorescens) 		4 / 6 TYR A 301
HIS A  57
ILE A 296
TYR A  73
 None
 1.25A 5ih0A-2q9tA:
undetectable		 5ih0A-2q9tA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 2q9t DING
(Pseudomonas
fluorescens) 		4 / 5 GLU A  69
GLY A  33
SER A  63
GLY A 146
 None
None
None
PO4  A 901 (-3.6A)
 1.09A 5kprA-2q9tA:
undetectable		 5kprA-2q9tA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 2q9t DING
(Pseudomonas
fluorescens) 		4 / 4 THR A  92
VAL A  90
PRO A  10
THR A 293
 None
 1.36A 5mthA-2q9tA:
undetectable
5mthH-2q9tA:
undetectable		 5mthA-2q9tA:
21.47
5mthH-2q9tA:
21.47