SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qa2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 10 LEU A 417
ALA A 455
ASP A 454
GLY A 450
PRO A 392
 None
 1.21A 1d4sA-2qa2A:
undetectable		 1d4sA-2qa2A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 12 LEU A  15
ALA A  18
ALA A 107
ALA A  62
ILE A  59
 None
 1.02A 1fk6A-2qa2A:
undetectable		 1fk6A-2qa2A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 12 HIS A 323
TYR A 265
LEU A 272
VAL A 158
LEU A 330
 None
 1.40A 2prgB-2qa2A:
undetectable		 2prgB-2qa2A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		4 / 7 ASP A  27
VAL A  26
ALA A 303
THR A 145
 None
 0.98A 2q6oA-2qa2A:
undetectable		 2q6oA-2qa2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		4 / 6 PHE A  81
GLY A 284
GLY A 285
ASN A 289
 None
None
FAD  A 500 (-3.1A)
FAD  A 500 (-3.6A)
 0.80A 2qr2A-2qa2A:
undetectable
2qr2B-2qa2A:
undetectable		 2qr2A-2qa2A:
18.44
2qr2B-2qa2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 10 VAL A 149
LEU A  21
ARG A  22
GLY A  19
ALA A 107
 None
 1.11A 2xf3A-2qa2A:
undetectable		 2xf3A-2qa2A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		4 / 8 VAL A 149
ARG A  22
GLY A  19
ALA A 107
 None
 0.87A 2xfsA-2qa2A:
undetectable		 2xfsA-2qa2A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		4 / 8 VAL A 149
ARG A  22
GLY A  19
ALA A 107
 None
 0.86A 2xh9A-2qa2A:
undetectable		 2xh9A-2qa2A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 9 ALA A  48
GLY A  72
LEU A 373
LEU A  84
ALA A  87
 None
 0.93A 2z0yA-2qa2A:
undetectable		 2z0yA-2qa2A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		4 / 7 GLU A 231
ARG A 238
ARG A 223
GLU A 174
 None
 1.26A 2zt7A-2qa2A:
3.0		 2zt7A-2qa2A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		3 / 3 SER A 291
GLU A 100
ASP A 275
 FAD  A 500 ( 3.8A)
FAD  A 500 ( 4.9A)
FAD  A 500 (-3.1A)
 0.66A 2zthA-2qa2A:
2.8		 2zthA-2qa2A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		4 / 8 VAL A   7
GLY A  19
GLY A 111
ALA A 112
 None
 0.54A 3aruA-2qa2A:
undetectable		 3aruA-2qa2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		3 / 3 SER A 291
GLU A 100
ASP A 275
 FAD  A 500 ( 3.8A)
FAD  A 500 ( 4.9A)
FAD  A 500 (-3.1A)
 0.79A 3bwmA-2qa2A:
2.8		 3bwmA-2qa2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		3 / 3 SER A 291
GLU A 100
ASP A 275
 FAD  A 500 ( 3.8A)
FAD  A 500 ( 4.9A)
FAD  A 500 (-3.1A)
 0.73A 3bwyA-2qa2A:
2.8		 3bwyA-2qa2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		3 / 3 SER A 276
ASP A 152
ASP A 294
 None
FAD  A 500 (-4.8A)
None
 0.84A 3iv6A-2qa2A:
undetectable		 3iv6A-2qa2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		3 / 3 SER A 276
ASP A 152
ASP A 294
 None
FAD  A 500 (-4.8A)
None
 0.81A 3iv6C-2qa2A:
undetectable		 3iv6C-2qa2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 10 VAL A  79
VAL A 370
GLN A 286
ILE A 190
GLY A  72
 None
 1.28A 3km6A-2qa2A:
undetectable		 3km6A-2qa2A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		4 / 5 TYR A  89
THR A  47
PHE A  46
LEU A  44
 None
 1.46A 3qelC-2qa2A:
undetectable		 3qelC-2qa2A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		3 / 3 LEU A  60
ARG A 390
ASN A 289
 None
None
FAD  A 500 (-3.6A)
 0.58A 3qxvD-2qa2A:
undetectable		 3qxvD-2qa2A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		3 / 3 LEU A 366
HIS A 365
MET A 369
 None
 0.64A 3thrD-2qa2A:
2.4		 3thrD-2qa2A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		3 / 3 ARG A 159
PHE A 166
PRO A 167
 None
 0.80A 3zoaB-2qa2A:
undetectable		 3zoaB-2qa2A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		4 / 6 PHE A 176
ALA A 235
ALA A 218
PRO A 219
 None
 0.68A 4dtzA-2qa2A:
undetectable		 4dtzA-2qa2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		4 / 6 PHE A 176
ALA A 235
ALA A 218
PRO A 219
 None
 0.66A 4dtzB-2qa2A:
undetectable		 4dtzB-2qa2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		4 / 7 PHE A 176
ALA A 235
ALA A 218
PRO A 219
 None
 0.71A 4du2A-2qa2A:
undetectable		 4du2A-2qa2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		4 / 7 PHE A 176
ALA A 235
ALA A 218
PRO A 219
 None
 0.70A 4du2B-2qa2A:
undetectable		 4du2B-2qa2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 12 VAL A  94
ALA A  93
PHE A  54
PHE A  63
THR A  99
 None
 0.89A 4mm4B-2qa2A:
undetectable		 4mm4B-2qa2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 12 VAL A  94
ALA A  93
PHE A  54
PHE A  63
THR A  99
 None
 1.06A 4mm6A-2qa2A:
undetectable		 4mm6A-2qa2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 12 VAL A   8
LEU A 272
GLY A 150
ASP A 152
LEU A 123
 FAD  A 500 ( 4.9A)
None
None
FAD  A 500 (-4.8A)
None
 1.06A 4o5fA-2qa2A:
undetectable
4o5fB-2qa2A:
undetectable		 4o5fA-2qa2A:
23.15
4o5fB-2qa2A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 12 LEU A 123
VAL A   8
LEU A 272
GLY A 150
ASP A 152
 None
FAD  A 500 ( 4.9A)
None
None
FAD  A 500 (-4.8A)
 1.05A 4o5fA-2qa2A:
undetectable
4o5fB-2qa2A:
undetectable		 4o5fA-2qa2A:
23.15
4o5fB-2qa2A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		3 / 3 PRO A 282
LEU A 281
GLN A 336
 FAD  A 500 (-4.5A)
None
None
 0.72A 4pevB-2qa2A:
undetectable		 4pevB-2qa2A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		4 / 5 THR A  47
THR A  50
HIS A 278
ASN A 332
 None
 1.27A 4pgfB-2qa2A:
undetectable		 4pgfB-2qa2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWL_A_ASCA303_0
(DIOSCORIN 5)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 10 GLN A 293
VAL A 292
PHE A  46
THR A  47
ALA A  48
 None
 1.31A 4twlA-2qa2A:
undetectable		 4twlA-2qa2A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		3 / 3 ASP A 294
LEU A 329
GLY A 326
 None
 0.54A 4xmfA-2qa2A:
undetectable		 4xmfA-2qa2A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		3 / 3 SER A 291
GLU A 100
ASP A 275
 FAD  A 500 ( 3.8A)
FAD  A 500 ( 4.9A)
FAD  A 500 (-3.1A)
 0.70A 4xudA-2qa2A:
2.5		 4xudA-2qa2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 12 VAL A   8
LEU A 272
GLY A 150
ASP A 152
LEU A 123
 FAD  A 500 ( 4.9A)
None
None
FAD  A 500 (-4.8A)
None
 1.04A 5b8hA-2qa2A:
undetectable
5b8hB-2qa2A:
undetectable		 5b8hA-2qa2A:
24.32
5b8hB-2qa2A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 12 LEU A 123
VAL A   8
LEU A 272
GLY A 150
ASP A 152
 None
FAD  A 500 ( 4.9A)
None
None
FAD  A 500 (-4.8A)
 1.02A 5b8hA-2qa2A:
undetectable
5b8hB-2qa2A:
undetectable		 5b8hA-2qa2A:
24.32
5b8hB-2qa2A:
24.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 12 GLY A  45
ILE A 212
PHE A 255
GLY A 284
GLY A 285
 None
None
FAD  A 500 ( 4.5A)
None
FAD  A 500 (-3.1A)
 0.64A 5koxA-2qa2A:
53.7		 5koxA-2qa2A:
42.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 12 ILE A 469
LEU A 386
GLY A 472
ASP A 383
GLY A 382
 None
 1.18A 5nnaD-2qa2A:
undetectable		 5nnaD-2qa2A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		4 / 7 GLY A  14
GLY A   9
SER A 101
ALA A 107
 None
FAD  A 500 (-3.2A)
None
None
 0.77A 5o96C-2qa2A:
undetectable		 5o96C-2qa2A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		3 / 3 GLU A 126
HIS A 129
ARG A 269
 None
 1.00A 5uunA-2qa2A:
undetectable		 5uunA-2qa2A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 12 ALA A 273
GLY A 274
LEU A  17
LEU A 302
ARG A 159
 None
FAD  A 500 (-3.3A)
None
None
None
 1.14A 5w7pA-2qa2A:
undetectable		 5w7pA-2qa2A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		4 / 6 GLY A  45
SER A  41
THR A  98
VAL A  94
 None
 1.12A 5ysiA-2qa2A:
undetectable		 5ysiA-2qa2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 12 GLN A 293
VAL A 325
ARG A 390
ILE A 375
ASP A 374
 None
 1.33A 6bxnA-2qa2A:
2.2		 6bxnA-2qa2A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 12 GLN A 293
VAL A 325
ARG A 390
ILE A 375
ASP A 374
 None
 1.33A 6bxnB-2qa2A:
undetectable		 6bxnB-2qa2A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		4 / 8 ASP A 294
TYR A 318
GLY A 268
VAL A 148
 None
 0.95A 6giqL-2qa2A:
undetectable
6giqP-2qa2A:
undetectable
6giqT-2qa2A:
undetectable		 6giqL-2qa2A:
22.08
6giqP-2qa2A:
17.99
6giqT-2qa2A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 12 GLY A  76
GLY A  75
VAL A 370
ASN A 332
GLY A 284
 None
 1.14A 6gneA-2qa2A:
undetectable		 6gneA-2qa2A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 2qa2 POLYKETIDE OXYGENASE
CABE
(Streptomyces) 		5 / 12 GLY A  76
GLY A  75
VAL A 370
ASN A 332
GLY A 284
 None
 1.14A 6gneB-2qa2A:
2.3		 6gneB-2qa2A:
22.87