SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qag'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2qag SEPTIN-2
SEPTIN-6
(Homo
sapiens;
Homo
sapiens) 		4 / 7 PHE A 156
ALA B 188
ILE B 183
PRO B 157
 None
 0.80A 1oniA-2qagA:
undetectable
1oniB-2qagA:
undetectable		 1oniA-2qagA:
16.06
1oniB-2qagA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2qag SEPTIN-2
SEPTIN-6
(Homo
sapiens;
Homo
sapiens) 		4 / 6 PHE A 156
ALA B 188
ILE B 183
PRO B 157
 None
 1.13A 1oniH-2qagA:
undetectable
1oniI-2qagA:
undetectable		 1oniH-2qagA:
16.06
1oniI-2qagA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2qag SEPTIN-2
SEPTIN-6
(Homo
sapiens;
Homo
sapiens) 		4 / 7 ILE B 183
PRO B 157
PHE A 156
ALA B 188
 None
 0.81A 1oniG-2qagB:
undetectable
1oniI-2qagB:
undetectable		 1oniG-2qagB:
15.28
1oniI-2qagB:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2qag SEPTIN-2
(Homo
sapiens) 		5 / 12 THR A  39
PHE A  38
PHE A  58
VAL A 180
PHE A 152
 None
 1.39A 1q23C-2qagA:
undetectable		 1q23C-2qagA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2qag SEPTIN-2
(Homo
sapiens) 		5 / 11 THR A  39
PHE A  38
PHE A  58
VAL A 180
PHE A 152
 None
 1.41A 1q23L-2qagA:
undetectable		 1q23L-2qagA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2qag SEPTIN-2
(Homo
sapiens) 		3 / 3 VAL A  79
VAL A  42
ASP A 143
 None
 0.64A 2fumD-2qagA:
undetectable		 2fumD-2qagA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2qag SEPTIN-2
(Homo
sapiens) 		4 / 6 LEU A 276
VAL A 165
MET A 168
ILE A 210
 None
 1.17A 2hyyC-2qagA:
undetectable		 2hyyC-2qagA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 2qag SEPTIN-2
(Homo
sapiens) 		4 / 8 ARG A 192
ALA A 184
ILE A 181
PRO A 236
 None
 0.95A 3fxrA-2qagA:
undetectable		 3fxrA-2qagA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2qag SEPTIN-2
SEPTIN-6
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS B 185
ARG A 194
LEU A 187
 GTP  B 428 (-2.8A)
GTP  B 428 (-3.6A)
None
 1.18A 3v4tE-2qagB:
undetectable		 3v4tE-2qagB:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 2qag SEPTIN-2
SEPTIN-6
(Homo
sapiens;
Homo
sapiens) 		4 / 4 TYR A 258
THR A 186
VAL A 240
ILE B 189
 GDP  A 362 (-4.7A)
None
GDP  A 362 (-2.5A)
None
 1.06A 4jx1F-2qagA:
undetectable		 4jx1F-2qagA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2qag SEPTIN-2
(Homo
sapiens) 		5 / 12 GLY A 241
PHE A 167
ILE A 171
THR A  98
THR A  52
 None
None
None
None
GDP  A 362 (-3.9A)
 1.19A 5eskA-2qagA:
undetectable		 5eskA-2qagA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2qag SEPTIN-2
(Homo
sapiens) 		4 / 7 GLY A 241
LYS A 183
ALA A 182
ASN A  55
 None
GDP  A 362 (-3.9A)
None
None
 0.88A 5mvsA-2qagA:
undetectable		 5mvsA-2qagA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 2qag SEPTIN-2
(Homo
sapiens) 		4 / 8 LEU A 200
HIS A 212
LEU A 160
ILE A 210
 None
 1.02A 5v0vA-2qagA:
undetectable		 5v0vA-2qagA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2qag SEPTIN-2
(Homo
sapiens) 		4 / 8 THR A  98
PHE A 126
VAL A  79
ILE A 119
 None
 1.03A 5vkqB-2qagA:
undetectable
5vkqC-2qagA:
undetectable		 5vkqB-2qagA:
11.57
5vkqC-2qagA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 2qag SEPTIN-2
(Homo
sapiens) 		4 / 4 PHE A 150
LEU A  62
LEU A  53
VAL A  99
 None
 1.36A 5xxiA-2qagA:
undetectable		 5xxiA-2qagA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2qag SEPTIN-2
(Homo
sapiens) 		5 / 12 GLY A 241
PHE A 167
ILE A 171
THR A  98
THR A  52
 None
None
None
None
GDP  A 362 (-3.9A)
 1.18A 6e8qA-2qagA:
undetectable		 6e8qA-2qagA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2qag SEPTIN-2
(Homo
sapiens) 		4 / 8 HIS A 212
GLU A 289
ASP A 293
GLU A 297
 None
 1.16A 6mn4A-2qagA:
undetectable		 6mn4A-2qagA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2qag SEPTIN-2
(Homo
sapiens) 		4 / 8 HIS A 212
GLU A 289
ASP A 293
GLU A 297
 None
 1.10A 6mn4B-2qagA:
undetectable		 6mn4B-2qagA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2qag SEPTIN-2
(Homo
sapiens) 		4 / 8 HIS A 212
GLU A 289
ASP A 293
GLU A 297
 None
 1.21A 6mn4C-2qagA:
undetectable		 6mn4C-2qagA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2qag SEPTIN-2
(Homo
sapiens) 		4 / 7 HIS A 212
GLU A 289
ASP A 293
GLU A 297
 None
 1.08A 6mn4F-2qagA:
undetectable		 6mn4F-2qagA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2qag SEPTIN-2
(Homo
sapiens) 		4 / 6 TYR A 211
GLU A 289
ASP A 293
GLU A 297
 None
 1.46A 6mn5A-2qagA:
undetectable		 6mn5A-2qagA:
11.63