SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qb6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_1
(VITAMIN D3 RECEPTOR)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A 204
ARG A 208
HIS A 149
HIS A 148
 GOL  A 804 (-3.2A)
GOL  A 804 (-3.0A)
SO4  A 501 (-4.2A)
MN  A 401 ( 3.3A)
 1.28A 1s19A-2qb6A:
0.0		 1s19A-2qb6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 12 MET A 206
GLY A 197
VAL A  88
ALA A  44
ALA A 198
 EDO  A 801 (-4.7A)
None
None
None
None
 1.43A 2avdA-2qb6A:
undetectable		 2avdA-2qb6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 345
LEU A 348
VAL A 352
THR A 324
VAL A 384
 None
 1.18A 2cbrA-2qb6A:
undetectable		 2cbrA-2qb6A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 320
LEU A 339
ILE A 287
THR A 324
LEU A 388
 None
 1.25A 2ft9A-2qb6A:
undetectable		 2ft9A-2qb6A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A 203
SER A 171
ASP A 214
SER A 170
 None
 1.47A 2hdnA-2qb6A:
undetectable
2hdnB-2qb6A:
undetectable
2hdnD-2qb6A:
2.2		 2hdnA-2qb6A:
8.91
2hdnB-2qb6A:
22.28
2hdnD-2qb6A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 149
ASP A 127
HIS A 148
ASP A  41
 SO4  A 501 (-4.2A)
MN  A 401 (-2.4A)
MN  A 401 ( 3.3A)
MN  A 401 (-3.1A)
 1.25A 3c0zA-2qb6A:
undetectable		 3c0zA-2qb6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 5 VAL A  91
LEU A  92
ILE A  43
ALA A  44
 None
 0.95A 3n8yB-2qb6A:
undetectable		 3n8yB-2qb6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 11 ARG A 315
LEU A 317
GLU A 389
PHE A 272
VAL A 321
 None
 1.28A 3ua5A-2qb6A:
0.1		 3ua5A-2qb6A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 391
ASN A 394
LEU A 395
 None
 0.25A 5i1nC-2qb6A:
undetectable		 5i1nC-2qb6A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 391
ASN A 394
LEU A 395
 None
 0.36A 5i1nB-2qb6A:
undetectable		 5i1nB-2qb6A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 391
ASN A 394
LEU A 395
 None
 0.23A 5i1oC-2qb6A:
undetectable		 5i1oC-2qb6A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 391
ASN A 394
LEU A 395
 None
 0.43A 5i1oA-2qb6A:
undetectable		 5i1oA-2qb6A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 391
ASN A 394
LEU A 395
 None
 0.14A 5i1pA-2qb6A:
undetectable		 5i1pA-2qb6A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 391
ASN A 394
LEU A 395
 None
 0.21A 5i1pD-2qb6A:
undetectable		 5i1pD-2qb6A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 322
ILE A 287
THR A 380
LEU A 320
LEU A 317
 None
None
SO4  A 501 ( 4.6A)
None
None
 0.96A 5nfjA-2qb6A:
undetectable		 5nfjA-2qb6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 322
ILE A 287
THR A 380
LEU A 320
LEU A 317
 None
None
SO4  A 501 ( 4.6A)
None
None
 0.88A 5nfjB-2qb6A:
undetectable		 5nfjB-2qb6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 322
ILE A 287
THR A 380
LEU A 320
LEU A 317
 None
None
SO4  A 501 ( 4.6A)
None
None
 0.88A 5nfjC-2qb6A:
undetectable		 5nfjC-2qb6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 147
LEU A 108
ASP A  76
ALA A  46
GLY A 144
 None
 1.28A 5syeB-2qb6A:
undetectable		 5syeB-2qb6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 4 ASP A  39
SER A  42
ASP A  41
HIS A 148
 MN  A 401 ( 4.7A)
None
MN  A 401 (-3.1A)
MN  A 401 ( 3.3A)
 1.48A 5wyqB-2qb6A:
0.9		 5wyqB-2qb6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 2qb6 EXOPOLYPHOSPHATASE
(Saccharomyces
cerevisiae) 		4 / 7 SER A  45
ALA A 198
ILE A 218
ALA A 217
 None
None
EDO  A 801 ( 4.6A)
None
 0.80A 6ma7A-2qb6A:
undetectable		 6ma7A-2qb6A:
11.68