SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qbu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 2qbu PRECORRIN-2
METHYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 LEU A  53
LEU A  26
LEU A  18
ILE A  48
ALA A  45
 None
 1.08A 1ha2A-2qbuA:
undetectable		 1ha2A-2qbuA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2qbu PRECORRIN-2
METHYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ARG A 143
VAL A 209
GLY A 217
 None
 0.63A 2avvE-2qbuA:
undetectable		 2avvE-2qbuA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 2qbu PRECORRIN-2
METHYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 VAL A   8
ILE A 100
SER A  28
ARG A  56
 None
 0.96A 3pglA-2qbuA:
undetectable		 3pglA-2qbuA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2qbu PRECORRIN-2
METHYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 PHE A 214
LEU A 153
VAL A 165
VAL A 155
PHE A 228
 None
 1.41A 3u9fB-2qbuA:
undetectable
3u9fC-2qbuA:
undetectable		 3u9fB-2qbuA:
20.39
3u9fC-2qbuA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2qbu PRECORRIN-2
METHYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 PHE A 162
ASP A 160
ARG A 183
 None
 0.90A 4eahF-2qbuA:
undetectable		 4eahF-2qbuA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 2qbu PRECORRIN-2
METHYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 GLY A   7
GLU A 126
THR A 125
 None
 0.51A 4kouA-2qbuA:
1.5		 4kouA-2qbuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2qbu PRECORRIN-2
METHYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ILE A  48
LEU A  53
ILE A  62
ALA A  34
LEU A 102
 None
 0.96A 4o1zA-2qbuA:
undetectable		 4o1zA-2qbuA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 2qbu PRECORRIN-2
METHYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 181
ALA A 184
VAL A 188
PHE A 214
SER A 199
 None
 1.18A 4pd9A-2qbuA:
undetectable		 4pd9A-2qbuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2qbu PRECORRIN-2
METHYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 ASN A 202
SER A 178
ALA A 201
VAL A 200
 None
 1.25A 4x1kC-2qbuA:
undetectable		 4x1kC-2qbuA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 2qbu PRECORRIN-2
METHYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 VAL A 226
THR A 224
LEU A 166
VAL A 158
 None
 0.96A 5e4dA-2qbuA:
undetectable
5e4dB-2qbuA:
undetectable		 5e4dA-2qbuA:
21.89
5e4dB-2qbuA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2qbu PRECORRIN-2
METHYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 7 GLY A   9
GLY A 130
SER A  15
THR A 101
ALA A  45
 None
 1.22A 5o96C-2qbuA:
undetectable		 5o96C-2qbuA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2qbu PRECORRIN-2
METHYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ASP A 120
ARG A 117
ASP A  81
GLU A  77
 None
 0.93A 6mn4A-2qbuA:
undetectable		 6mn4A-2qbuA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2qbu PRECORRIN-2
METHYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ASP A 120
ARG A 117
ASP A  81
GLU A  77
 None
 0.95A 6mn4B-2qbuA:
undetectable		 6mn4B-2qbuA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2qbu PRECORRIN-2
METHYLTRANSFERASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ASP A 120
ARG A 117
ASP A  81
GLU A  77
 None
 1.12A 6mn4C-2qbuA:
undetectable		 6mn4C-2qbuA:
25.91