SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qbx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FM6_D_BRLD503_2 (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA)	2qbx	EPHRIN TYPE-B RECEPTOR 2 (Homo sapiens)	4 / 4	ILE A 86 LEU A 121 VAL A 96 ILE A 94	None	0.85A	1fm6D-2qbxA: undetectable	1fm6D-2qbxA: 21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LP1_A_NVPA701_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	2qbx	EPHRIN TYPE-B RECEPTOR 2 (Homo sapiens)	5 / 10	ASN A 79 VAL A 69 TYR A 67 GLY A 50 TRP A 43	None	1.48A	3lp1A-2qbxA: undetectable	3lp1A-2qbxA: 17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UDC_A_DEXA1778_2 (GLUCOCORTICOID RECEPTOR)	2qbx	EPHRIN TYPE-B RECEPTOR 2 (Homo sapiens)	3 / 3	MET A 44 GLN A 187 TYR A 122	None	1.07A	4udcA-2qbxA: undetectable	4udcA-2qbxA: 19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_B_ACTB310_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	2qbx	EPHRIN TYPE-B RECEPTOR 2 (Homo sapiens)	4 / 4	GLY A 175 PRO A 176 VAL A 177 ARG A 93	None	1.49A	5uunA-2qbxA: 0.0 5uunB-2qbxA: 0.0	5uunA-2qbxA: 23.13 5uunB-2qbxA: 23.13

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FM6_D_BRLD503_2","PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA","2qbx","EPHRIN TYPE-B RECEPTOR 2","Homo sapiens",4,"ILE A  86;LEU A 121;VAL A  96;ILE A  94","None","0.85A","1fm6D-2qbxA:undetectable","1fm6D-2qbxA:21.11"],["3LP1_A_NVPA701_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","2qbx","EPHRIN TYPE-B RECEPTOR 2","Homo sapiens",5,"ASN A  79;VAL A  69;TYR A  67;GLY A  50;TRP A  43","None","1.48A","3lp1A-2qbxA:undetectable","3lp1A-2qbxA:17.73"],["4UDC_A_DEXA1778_2","GLUCOCORTICOID RECEPTOR","2qbx","EPHRIN TYPE-B RECEPTOR 2","Homo sapiens",3,"MET A  44;GLN A 187;TYR A 122","None","1.07A","4udcA-2qbxA:undetectable","4udcA-2qbxA:19.73"],["5UUN_B_ACTB310_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN","2qbx","EPHRIN TYPE-B RECEPTOR 2","Homo sapiens",4,"GLY A 175;PRO A 176;VAL A 177;ARG A  93","None","1.49A","5uunA-2qbxA:0.0;5uunB-2qbxA:0.0","5uunA-2qbxA:23.13;5uunB-2qbxA:23.13"]]