SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qby'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		4 / 4 ILE B 163
MET B 190
VAL B 177
GLY B 161
 None
 1.32A 1e06B-2qbyB:
undetectable		 1e06B-2qbyB:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		5 / 12 ASP A 149
GLU A 147
ASP A 146
ASP A 254
THR A  70
 None
MG  A   6 ( 4.3A)
MG  A   6 (-4.0A)
None
MG  A   6 ( 3.2A)
 1.29A 1kijA-2qbyA:
undetectable		 1kijA-2qbyA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		5 / 9 LEU B 149
VAL B 164
VAL B 156
GLY B 161
LEU B 113
 None
 1.33A 1lwfA-2qbyB:
undetectable		 1lwfA-2qbyB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		5 / 12 ASP A 149
GLU A 147
ASP A 146
ASP A 254
THR A  70
 None
MG  A   6 ( 4.3A)
MG  A   6 (-4.0A)
None
MG  A   6 ( 3.2A)
 1.25A 1s14A-2qbyA:
undetectable		 1s14A-2qbyA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		4 / 8 ILE A 175
PHE A 177
ARG A 165
LEU A 130
 None
 0.87A 1v55N-2qbyA:
undetectable
1v55W-2qbyA:
undetectable		 1v55N-2qbyA:
20.30
1v55W-2qbyA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		4 / 5 ARG B 193
ASP A 107
ILE A  93
GLU B 191
 None
 1.44A 2xrzA-2qbyB:
undetectable
2xrzB-2qbyB:
undetectable		 2xrzA-2qbyB:
21.69
2xrzB-2qbyB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		4 / 8 LYS A  55
LEU A 145
ASP A 149
GLU A 200
 None
 1.09A 2zw9A-2qbyA:
undetectable		 2zw9A-2qbyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		5 / 11 CYH B  99
LEU B 149
ILE B 180
VAL B 194
LEU B 195
 None
 1.37A 3a9eB-2qbyB:
undetectable		 3a9eB-2qbyB:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		4 / 8 ILE A 175
PHE A 177
ARG A 165
LEU A 130
 None
 0.93A 3abkA-2qbyA:
undetectable
3abkJ-2qbyA:
undetectable		 3abkA-2qbyA:
20.30
3abkJ-2qbyA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		4 / 8 ILE A 175
PHE A 177
ARG A 165
LEU A 130
 None
 0.86A 3abmN-2qbyA:
undetectable
3abmW-2qbyA:
undetectable		 3abmN-2qbyA:
20.30
3abmW-2qbyA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		4 / 8 ILE A 175
PHE A 177
ARG A 165
LEU A 130
 None
 0.85A 3asoN-2qbyA:
undetectable
3asoW-2qbyA:
undetectable		 3asoN-2qbyA:
20.30
3asoW-2qbyA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		5 / 12 PHE A 225
LEU A 230
ALA A 221
ALA A 224
GLU A 264
 None
 1.12A 3cwkA-2qbyA:
undetectable		 3cwkA-2qbyA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		5 / 12 LEU A 160
SER A 197
ASN A  58
LEU A 145
THR A  95
 None
 1.26A 3fsuA-2qbyA:
undetectable		 3fsuA-2qbyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		4 / 8 PHE B 204
GLY B  62
ILE B 178
PHE B  70
 None
None
None
ADP  B   9 (-4.2A)
 0.94A 3ko0O-2qbyB:
undetectable
3ko0Q-2qbyB:
1.8		 3ko0O-2qbyB:
14.53
3ko0Q-2qbyB:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		5 / 12 THR A 325
VAL A 343
ILE A 347
ILE A 372
SER A 317
 None
 1.27A 3kpbC-2qbyA:
undetectable		 3kpbC-2qbyA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		4 / 8 LEU B 113
SER B 111
LEU B 165
ILE B 136
 None
 0.95A 3ln1A-2qbyB:
undetectable		 3ln1A-2qbyB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		4 / 7 LEU B 113
SER B 111
LEU B 165
ILE B 136
 None
 0.95A 3ln1B-2qbyB:
undetectable		 3ln1B-2qbyB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		5 / 12 ASP A 149
GLU A 147
ASP A 146
ASP A 254
THR A  70
 None
MG  A   6 ( 4.3A)
MG  A   6 (-4.0A)
None
MG  A   6 ( 3.2A)
 1.39A 3lpsA-2qbyA:
undetectable		 3lpsA-2qbyA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		3 / 3 ASP A 107
ARG A 103
ALA A 106
 None
 0.69A 3mbgC-2qbyA:
undetectable		 3mbgC-2qbyA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		4 / 5 LEU A 105
LEU A 109
LEU A 121
SER A 122
 None
 1.04A 3vhuA-2qbyA:
undetectable		 3vhuA-2qbyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		5 / 12 VAL A 134
ILE A 143
TYR A 127
ILE A  98
LEU A 112
 None
 1.26A 4a84A-2qbyA:
undetectable		 4a84A-2qbyA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		5 / 11 ILE B 147
ALA B 114
LEU B 113
VAL B 109
LEU B 168
 None
 1.07A 4g1bB-2qbyB:
undetectable		 4g1bB-2qbyB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		3 / 3 LYS B  51
TYR B  48
ARG B  47
 None
 1.06A 4gc9A-2qbyB:
undetectable		 4gc9A-2qbyB:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		5 / 10 TYR A 127
LEU A 163
LEU A 126
LEU A 109
LEU A 145
 None
 1.04A 4odoB-2qbyA:
undetectable		 4odoB-2qbyA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		5 / 10 TYR A 127
LEU A 163
LEU A 126
LEU A 109
LEU A 145
 None
 1.03A 4odoC-2qbyA:
undetectable		 4odoC-2qbyA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		5 / 11 THR B 228
ALA B 259
GLY B 266
GLY B 264
SER B 263
 None
 0.96A 4qvwK-2qbyB:
undetectable
4qvwL-2qbyB:
undetectable		 4qvwK-2qbyB:
20.10
4qvwL-2qbyB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		5 / 11 THR B 228
ALA B 259
GLY B 266
GLY B 264
SER B 263
 None
 0.96A 4qvwY-2qbyB:
undetectable
4qvwZ-2qbyB:
undetectable		 4qvwY-2qbyB:
20.10
4qvwZ-2qbyB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		4 / 4 ILE A 178
ASN A  58
ILE A 175
VAL A 141
 None
 1.18A 4uy87-2qbyA:
undetectable		 4uy87-2qbyA:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		5 / 12 VAL A 144
ILE A  61
ILE A  59
ILE A  43
VAL A  72
 None
 1.00A 4y0rA-2qbyA:
undetectable		 4y0rA-2qbyA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		4 / 7 ILE A 175
PHE A 177
ARG A 165
LEU A 130
 None
 0.89A 5b1bN-2qbyA:
undetectable
5b1bW-2qbyA:
undetectable		 5b1bN-2qbyA:
20.30
5b1bW-2qbyA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		4 / 7 ILE A 175
PHE A 177
ARG A 165
LEU A 130
 None
 0.88A 5b3sN-2qbyA:
undetectable
5b3sW-2qbyA:
undetectable		 5b3sN-2qbyA:
20.30
5b3sW-2qbyA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		4 / 6 PRO A  30
HIS A  35
GLU A 211
ALA A 242
 None
 1.09A 5igiA-2qbyA:
undetectable		 5igiA-2qbyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		5 / 9 ILE A  61
VAL A 144
GLU A 201
LEU A  47
ILE A  43
 None
 1.34A 5mzpA-2qbyA:
undetectable		 5mzpA-2qbyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		3 / 3 THR A 318
THR A 369
ARG A 363
 None
 1.02A 5wm2A-2qbyA:
undetectable		 5wm2A-2qbyA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		5 / 11 ARG A 363
GLY A 373
ALA A 358
ILE A 347
VAL A 306
 None
 1.15A 5yk2A-2qbyA:
undetectable		 5yk2A-2qbyA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		4 / 8 ILE A 175
PHE A 177
ARG A 165
LEU A 130
 None
 0.93A 5zcpN-2qbyA:
undetectable
5zcpW-2qbyA:
undetectable		 5zcpN-2qbyA:
20.30
5zcpW-2qbyA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGG_Z_AG2Z503_0
(TRNA(ILE2)
2-AGMATINYLCYTIDINE
SYNTHETASE TIAS)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		4 / 5 GLU B 151
VAL B 102
CYH B  99
ARG B 100
 MG  B   7 ( 4.3A)
None
None
None
 1.43A 6aggZ-2qbyB:
0.0		 6aggZ-2qbyB:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		4 / 9 PHE B  22
VAL B 252
LEU B  26
VAL B  71
 None
 0.98A 6c2mD-2qbyB:
undetectable		 6c2mD-2qbyB:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		3 / 3 GLY A 354
ASP A 351
ILE A 372
 None
 0.48A 6dgxB-2qbyA:
undetectable		 6dgxB-2qbyA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		5 / 10 SER B 197
LEU B 149
LEU B  59
ILE B 147
SER B  57
 None
 1.33A 6dlzB-2qbyB:
2.4
6dlzC-2qbyB:
2.7		 6dlzB-2qbyB:
11.83
6dlzC-2qbyB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		5 / 11 ILE B 147
SER B  57
SER B 197
LEU B 149
LEU B  59
 None
 1.34A 6dlzA-2qbyB:
2.4
6dlzD-2qbyB:
2.9		 6dlzA-2qbyB:
11.83
6dlzD-2qbyB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		5 / 10 SER B 197
LEU B 149
LEU B  59
ILE B 147
SER B  57
 None
 1.33A 6dm1B-2qbyB:
2.2
6dm1C-2qbyB:
2.4		 6dm1B-2qbyB:
11.83
6dm1C-2qbyB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		5 / 11 ILE B 147
SER B  57
SER B 197
LEU B 149
LEU B  59
 None
 1.34A 6dm1A-2qbyB:
2.7
6dm1D-2qbyB:
2.1		 6dm1A-2qbyB:
11.83
6dm1D-2qbyB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1
(Sulfolobus
solfataricus) 		5 / 12 ILE A 159
PHE A 151
ASN A 156
ASP A  99
ILE A  93
 None
 1.30A 6dwnB-2qbyA:
undetectable		 6dwnB-2qbyA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3
(Sulfolobus
solfataricus) 		5 / 12 PHE B  60
GLY B  62
LEU B  63
GLY B  65
ILE B 178
 None
None
None
ADP  B   9 (-3.5A)
None
 1.09A 6mhtA-2qbyB:
undetectable		 6mhtA-2qbyB:
22.30