SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qc5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		4 / 8 ASP A 151
TRP A 155
TYR A 176
THR A 168
 ASP  A 151 ( 0.6A)
TRP  A 155 ( 0.5A)
TYR  A 176 ( 1.3A)
THR  A 168 ( 0.8A)
 1.07A 1ceaA-2qc5A:
undetectable
1ceaB-2qc5A:
undetectable		 1ceaA-2qc5A:
13.82
1ceaB-2qc5A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		4 / 8 ASP A 193
TRP A 197
TYR A 218
THR A 210
 ASP  A 193 ( 0.6A)
TRP  A 197 ( 0.5A)
TYR  A 218 ( 1.3A)
THR  A 210 ( 0.8A)
 1.13A 1ceaA-2qc5A:
undetectable
1ceaB-2qc5A:
undetectable		 1ceaA-2qc5A:
13.82
1ceaB-2qc5A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		4 / 8 SER A  99
LEU A 136
ASP A 120
GLU A 175
 SER  A  99 ( 0.0A)
LEU  A 136 ( 0.6A)
ASP  A 120 ( 0.5A)
GLU  A 175 ( 0.6A)
 1.21A 1mxgA-2qc5A:
undetectable		 1mxgA-2qc5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		5 / 12 PHE A 145
ASN A  75
ILE A  63
ILE A 112
THR A  73
 PHE  A 145 ( 1.3A)
ASN  A  75 ( 0.6A)
ILE  A  63 ( 0.4A)
ILE  A 112 ( 0.7A)
THR  A  73 ( 0.8A)
 1.30A 2bjfA-2qc5A:
undetectable		 2bjfA-2qc5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		5 / 12 ASN A 138
SER A 141
GLU A 175
PRO A 137
GLU A 217
 ASN  A 138 ( 0.6A)
SER  A 141 ( 0.0A)
GLU  A 175 ( 0.6A)
PRO  A 137 ( 1.1A)
GLU  A 217 ( 0.6A)
 1.46A 3jb2A-2qc5A:
undetectable		 3jb2A-2qc5A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		5 / 12 LEU A 196
ALA A 153
GLY A 149
SER A 150
LEU A 154
 LEU  A 196 ( 0.6A)
ALA  A 153 ( 0.0A)
GLY  A 149 ( 0.0A)
SER  A 150 ( 0.0A)
LEU  A 154 ( 0.5A)
 1.02A 3ou7A-2qc5A:
undetectable		 3ou7A-2qc5A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		4 / 7 ASN A 138
ILE A 122
LEU A 173
PHE A 156
 ASN  A 138 ( 0.6A)
ILE  A 122 ( 0.7A)
LEU  A 173 ( 0.6A)
PHE  A 156 ( 1.3A)
 0.80A 4ejjD-2qc5A:
undetectable		 4ejjD-2qc5A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		5 / 10 LEU A 125
ILE A 104
ILE A 131
GLY A 123
THR A  73
 LEU  A 125 ( 0.6A)
ILE  A 104 ( 0.6A)
ILE  A 131 ( 0.7A)
GLY  A 123 ( 0.0A)
THR  A  73 ( 0.8A)
 1.02A 4fakA-2qc5A:
undetectable		 4fakA-2qc5A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		5 / 12 TYR A 102
ILE A  20
GLY A  19
HIS A 228
ILE A 272
 TYR  A 102 ( 1.3A)
ILE  A  20 ( 0.7A)
GLY  A  19 (-0.0A)
HIS  A 228 ( 1.0A)
ILE  A 272 ( 0.7A)
 1.11A 4rvdA-2qc5A:
undetectable		 4rvdA-2qc5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		4 / 6 ILE A 272
GLY A 191
ASN A 192
ILE A 230
 ILE  A 272 ( 0.7A)
GLY  A 191 ( 0.0A)
ASN  A 192 ( 0.6A)
ILE  A 230 ( 0.6A)
 0.96A 5j4nB-2qc5A:
undetectable		 5j4nB-2qc5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		4 / 8 PHE A 198
ILE A 230
PRO A 221
PRO A 227
 PHE  A 198 ( 1.3A)
ILE  A 230 ( 0.6A)
PRO  A 221 ( 1.1A)
PRO  A 227 ( 1.1A)
 1.08A 5x23A-2qc5A:
undetectable		 5x23A-2qc5A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		4 / 8 ASN A 204
GLN A 247
ILE A 220
GLU A 259
 ASN  A 204 ( 0.6A)
GLN  A 247 ( 0.6A)
ILE  A 220 ( 0.7A)
GLU  A 259 ( 0.6A)
 1.08A 6hzpA-2qc5A:
undetectable		 6hzpA-2qc5A:
21.68