SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		5 / 11 GLY A 418
SER A 373
GLY A 450
ASP A 259
ILE A 277
 JW5  A 482 ( 4.9A)
None
JW5  A 482 (-3.4A)
JW5  A 482 (-2.9A)
None
 1.24A 1jzsA-2qcmA:
undetectable		 1jzsA-2qcmA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		3 / 3 ILE A 446
ILE A 448
THR A 252
 None
JW5  A 482 ( 4.6A)
None
 0.61A 1rg7A-2qcmA:
undetectable		 1rg7A-2qcmA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		4 / 6 LEU A 254
TYR A 466
ILE A 453
GLY A 418
 None
None
None
JW5  A 482 ( 4.9A)
 0.81A 2du8A-2qcmA:
undetectable		 2du8A-2qcmA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		4 / 6 LEU A 254
TYR A 466
ILE A 453
GLY A 418
 None
None
None
JW5  A 482 ( 4.9A)
 0.84A 2du8B-2qcmA:
undetectable		 2du8B-2qcmA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		5 / 11 LEU A 273
LEU A 298
ARG A 459
ILE A 453
VAL A 260
 None
 1.19A 2qd3A-2qcmA:
undetectable		 2qd3A-2qcmA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		5 / 10 ALA A 258
LEU A 280
ILE A 309
ALA A 337
VAL A 239
 None
 1.28A 3r9cA-2qcmA:
undetectable		 3r9cA-2qcmA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		3 / 3 ASP A 285
ARG A 313
ASP A 259
 None
None
JW5  A 482 (-2.9A)
 0.86A 4fp9A-2qcmA:
undetectable		 4fp9A-2qcmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		3 / 3 ASP A 285
ARG A 313
ASP A 259
 None
None
JW5  A 482 (-2.9A)
 0.86A 4fp9C-2qcmA:
undetectable		 4fp9C-2qcmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		3 / 3 ASP A 285
ARG A 313
ASP A 259
 None
None
JW5  A 482 (-2.9A)
 0.88A 4fp9F-2qcmA:
undetectable		 4fp9F-2qcmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		5 / 12 GLU A 265
ALA A 258
ARG A 459
ALA A 463
ALA A 272
 None
 0.95A 4oaeA-2qcmA:
undetectable		 4oaeA-2qcmA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		5 / 12 ALA A 302
LEU A 298
THR A 282
GLY A 274
PRO A 275
 None
 1.21A 4ypmA-2qcmA:
undetectable		 4ypmA-2qcmA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		4 / 5 ILE A 236
PHE A 412
SER A 394
ALA A 240
 None
 1.10A 5msdA-2qcmA:
2.4		 5msdA-2qcmA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		4 / 7 SER A 276
ILE A 277
LEU A 273
LEU A 460
 None
 1.02A 5u4sA-2qcmA:
2.4		 5u4sA-2qcmA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		4 / 4 VAL A 239
LEU A 243
LEU A 244
ASP A 445
 None
 1.35A 5xv7A-2qcmA:
undetectable		 5xv7A-2qcmA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		5 / 12 ALA A 342
GLY A 399
SER A 348
ASP A 317
ALA A 316
 None
 1.35A 5zvgA-2qcmA:
undetectable		 5zvgA-2qcmA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		5 / 12 ALA A 342
GLY A 399
SER A 348
ASP A 317
ALA A 316
 None
 1.35A 5zvgB-2qcmA:
undetectable		 5zvgB-2qcmA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		3 / 3 ASP A 289
ASP A 285
ASN A 341
 None
None
JW5  A 482 (-4.3A)
 0.83A 6gngB-2qcmA:
undetectable		 6gngB-2qcmA:
19.64