SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qdx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 ILE A 218
ILE A 251
THR A 115
 None
 0.58A 1rg7A-2qdxA:
2.8		 1rg7A-2qdxA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 225
PRO A 121
SER A  54
GLY A 116
 None
None
FAD  A 400 (-3.7A)
None
 1.07A 2qd5A-2qdxA:
2.4		 2qd5A-2qdxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 118
GLY A 143
GLY A 116
 None
 0.39A 3bogC-2qdxA:
undetectable		 3bogC-2qdxA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 6 THR A 192
ILE A 218
SER A 229
LEU A 232
 None
 0.94A 3deuB-2qdxA:
undetectable		 3deuB-2qdxA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 PRO A 106
GLY A 107
VAL A 100
ASP A 102
ASP A 248
 None
 0.96A 3m6vA-2qdxA:
3.4		 3m6vA-2qdxA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 PRO A 106
GLY A 107
VAL A 100
ASP A 102
ASP A 248
 None
 0.96A 3m6vB-2qdxA:
3.3		 3m6vB-2qdxA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 5 TYR A  53
PRO A 121
THR A  34
THR A  24
 FAD  A 400 (-3.9A)
None
None
None
 0.96A 3q07A-2qdxA:
undetectable		 3q07A-2qdxA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 5 TYR A  53
PRO A 121
THR A  34
THR A  24
 FAD  A 400 (-3.9A)
None
None
None
 0.96A 3q07B-2qdxA:
undetectable		 3q07B-2qdxA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 110
LEU A 113
VAL A 231
SER A 234
 None
 0.89A 3r9vA-2qdxA:
undetectable
3r9vB-2qdxA:
undetectable		 3r9vA-2qdxA:
21.43
3r9vB-2qdxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A  41
PHE A  20
PHE A  22
LEU A  83
 None
 0.88A 3v7pA-2qdxA:
undetectable		 3v7pA-2qdxA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 144
LEU A  99
MET A 217
 None
 0.90A 5ikrA-2qdxA:
undetectable		 5ikrA-2qdxA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 190
THR A 181
GLN A 191
GLY A 189
 SO4  A 401 (-4.0A)
SO4  A 401 (-3.1A)
None
None
 0.85A 5nzyA-2qdxA:
undetectable		 5nzyA-2qdxA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A  88
LEU A  83
LEU A  80
ILE A  40
GLU A   7
 None
 1.08A 5v0vA-2qdxA:
undetectable		 5v0vA-2qdxA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 120
SER A  54
LEU A  99
TYR A 132
PHE A  32
 FAD  A 400 (-3.6A)
FAD  A 400 (-3.7A)
None
None
None
 1.43A 5vlmA-2qdxA:
undetectable		 5vlmA-2qdxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		6 / 9 SER A  54
THR A 117
GLY A 118
ALA A 120
CYH A 219
GLU A 252
 FAD  A 400 (-3.7A)
FAD  A 400 (-3.2A)
None
FAD  A 400 (-3.6A)
None
FAD  A 400 ( 3.9A)
 0.52A 5vw4A-2qdxA:
8.1		 5vw4A-2qdxA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		6 / 9 THR A 117
GLY A 118
ALA A 120
CYH A 219
GLY A 220
GLU A 252
 FAD  A 400 (-3.2A)
None
FAD  A 400 (-3.6A)
None
None
FAD  A 400 ( 3.9A)
 0.70A 5vw4A-2qdxA:
8.1		 5vw4A-2qdxA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 118
CYH A 219
GLY A 220
GLU A 252
 None
None
None
FAD  A 400 ( 3.9A)
 0.63A 5vw5A-2qdxA:
20.8		 5vw5A-2qdxA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 8 SER A  54
THR A 117
GLY A 118
CYH A 219
GLU A 252
 FAD  A 400 (-3.7A)
FAD  A 400 (-3.2A)
None
None
FAD  A 400 ( 3.9A)
 0.52A 5vw5A-2qdxA:
20.8		 5vw5A-2qdxA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		6 / 8 SER A  54
THR A 117
GLY A 118
ALA A 120
CYH A 219
GLU A 252
 FAD  A 400 (-3.7A)
FAD  A 400 (-3.2A)
None
FAD  A 400 (-3.6A)
None
FAD  A 400 ( 3.9A)
 0.64A 5vw9A-2qdxA:
21.0		 5vw9A-2qdxA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		6 / 8 THR A 117
GLY A 118
ALA A 120
CYH A 219
GLY A 220
GLU A 252
 FAD  A 400 (-3.2A)
None
FAD  A 400 (-3.6A)
None
None
FAD  A 400 ( 3.9A)
 0.71A 5vw9A-2qdxA:
21.0		 5vw9A-2qdxA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 150
GLY A 116
ALA A 151
PHE A 255
THR A 115
 None
None
None
FAD  A 400 (-3.6A)
None
 1.31A 5x6yC-2qdxA:
undetectable		 5x6yC-2qdxA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  99
THR A 228
ILE A 218
LEU A 232
LEU A 110
 None
 1.30A 6ie8A-2qdxA:
undetectable		 6ie8A-2qdxA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 4 HIS A 109
LEU A 200
TYR A 177
GLY A 205
 None
 1.13A 6n91A-2qdxA:
undetectable		 6n91A-2qdxA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 2qdx FERREDOXIN REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 4 HIS A 109
LEU A 200
TYR A 177
GLY A 205
 None
 1.15A 6n91B-2qdxA:
undetectable		 6n91B-2qdxA:
15.07