SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qe6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 11 LEU A 169
LEU A  81
MET A 165
VAL A 177
ILE A 142
None
None
SAM  A 400 (-3.3A)
None
None
1.38A 1ee2A-2qe6A:
4.2
1ee2A-2qe6A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 ASP A 110
GLY A  86
ASP A  82
VAL A 136
GLY A 164
SAM  A 400 (-2.7A)
SAM  A 400 ( 3.2A)
None
SAM  A 400 (-3.8A)
SAM  A 400 (-3.5A)
0.91A 1hsgB-2qe6A:
undetectable
1hsgB-2qe6A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 ASP A 110
GLY A  86
ASP A  82
VAL A 136
GLY A 164
SAM  A 400 (-2.7A)
SAM  A 400 ( 3.2A)
None
SAM  A 400 (-3.8A)
SAM  A 400 (-3.5A)
0.98A 1k6cB-2qe6A:
undetectable
1k6cB-2qe6A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 GLY A  84
GLY A  86
ILE A 111
ASP A 112
ASP A 135
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-3.7A)
None
SAM  A 400 (-3.4A)
0.38A 1qaoA-2qe6A:
8.2
1qaoA-2qe6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 GLY A  84
GLY A  86
ILE A 111
ASP A 135
TYR A 168
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-3.7A)
SAM  A 400 (-3.4A)
SAM  A 400 ( 4.5A)
0.60A 1ri4A-2qe6A:
13.7
1ri4A-2qe6A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
4 / 7 TYR A  26
GLY A  86
ASP A 110
ASP A 135
SAM  A 400 ( 3.8A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
0.59A 2g72B-2qe6A:
13.3
2g72B-2qe6A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 ASP A  82
GLY A  84
GLY A  86
ILE A 111
ASP A 112
None
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-3.7A)
None
0.49A 2nxeA-2qe6A:
11.7
2nxeA-2qe6A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 ASP A  82
LEU A  83
GLY A  84
GLY A  86
ASP A 112
None
None
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
None
0.75A 2nxeA-2qe6A:
11.7
2nxeA-2qe6A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 ASP A  82
LEU A  83
GLY A  84
GLY A  86
LEU A 169
None
None
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
None
0.80A 2nxeA-2qe6A:
11.7
2nxeA-2qe6A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 ASP A  82
GLY A  84
GLY A  86
ILE A 111
ASP A 112
None
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-3.7A)
None
0.55A 2nxeB-2qe6A:
11.7
2nxeB-2qe6A:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
12 / 12 ILE A  22
ALA A  23
TYR A  26
GLY A  84
GLY A  86
ILE A 111
ASP A 135
VAL A 136
ARG A 137
VAL A 163
GLY A 164
TYR A 168
SAM  A 400 ( 3.7A)
SAM  A 400 (-3.1A)
SAM  A 400 ( 3.8A)
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-3.7A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.8A)
SAM  A 400 (-4.6A)
SAM  A 400 (-4.2A)
SAM  A 400 (-3.5A)
SAM  A 400 ( 4.5A)
0.21A 2qe6A-2qe6A:
51.6
2qe6A-2qe6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
3 / 3 ASN A  60
ARG A  61
ASP A 110
SAM  A 400 ( 3.5A)
SAM  A 400 (-3.7A)
SAM  A 400 (-2.7A)
0.00A 2qe6A-2qe6A:
51.6
2qe6A-2qe6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
12 / 12 ILE A  22
ALA A  23
TYR A  26
GLY A  84
GLY A  86
ILE A 111
ASP A 135
VAL A 136
ARG A 137
VAL A 163
GLY A 164
TYR A 168
SAM  A 400 ( 3.7A)
SAM  A 400 (-3.1A)
SAM  A 400 ( 3.8A)
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-3.7A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.8A)
SAM  A 400 (-4.6A)
SAM  A 400 (-4.2A)
SAM  A 400 (-3.5A)
SAM  A 400 ( 4.5A)
0.11A 2qe6B-2qe6A:
49.4
2qe6B-2qe6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
3 / 3 ASN A  60
ARG A  61
ASP A 110
SAM  A 400 ( 3.5A)
SAM  A 400 (-3.7A)
SAM  A 400 (-2.7A)
0.10A 2qe6B-2qe6A:
49.4
2qe6B-2qe6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
4 / 7 GLY A  86
ASP A 110
ASP A 135
ARG A 137
SAM  A 400 ( 3.2A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
SAM  A 400 (-4.6A)
0.47A 2uyqA-2qe6A:
16.9
2uyqA-2qe6A:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
4 / 7 VAL A 177
TYR A 181
ILE A 142
ASP A 135
None
None
None
SAM  A 400 (-3.4A)
1.11A 2x45B-2qe6A:
undetectable
2x45B-2qe6A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
4 / 7 VAL A 177
TYR A 181
ILE A 142
ASP A 135
None
None
None
SAM  A 400 (-3.4A)
1.11A 2x45C-2qe6A:
undetectable
2x45C-2qe6A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 GLY A  84
GLY A  86
ASP A 112
ARG A 137
VAL A 163
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
None
SAM  A 400 (-4.6A)
SAM  A 400 (-4.2A)
0.68A 2yqzA-2qe6A:
9.9
2yqzA-2qe6A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 TYR A  26
GLY A  86
ILE A 111
ASP A 135
VAL A 136
SAM  A 400 ( 3.8A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-3.7A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.8A)
0.91A 2zznA-2qe6A:
10.4
2zznA-2qe6A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 10 TYR A  26
ASP A 110
ILE A 111
ASP A 135
VAL A 136
SAM  A 400 ( 3.8A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.7A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.8A)
0.95A 3ay0A-2qe6A:
3.5
3ay0A-2qe6A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
6 / 10 TYR A  26
GLY A  86
ASP A 110
ILE A 111
ASP A 135
VAL A 136
SAM  A 400 ( 3.8A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.7A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.8A)
1.06A 3ay0B-2qe6A:
7.2
3ay0B-2qe6A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
4 / 7 VAL A 177
TYR A 181
ILE A 142
ASP A 135
None
None
None
SAM  A 400 (-3.4A)
1.05A 3bu1A-2qe6A:
undetectable
3bu1A-2qe6A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 ASP A  82
GLY A  84
ASP A 110
ILE A 111
ASP A 112
None
SAM  A 400 (-3.4A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.7A)
None
0.44A 3cjtC-2qe6A:
12.0
3cjtC-2qe6A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 ILE A 160
PHE A 154
LEU A 185
ALA A 186
VAL A 136
None
None
None
None
SAM  A 400 (-3.8A)
1.05A 3dzyA-2qe6A:
undetectable
3dzyA-2qe6A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 9 ASP A 110
GLY A  86
ASP A  82
VAL A 136
GLY A 164
SAM  A 400 (-2.7A)
SAM  A 400 ( 3.2A)
None
SAM  A 400 (-3.8A)
SAM  A 400 (-3.5A)
1.03A 3ektA-2qe6A:
undetectable
3ektA-2qe6A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 11 GLY A  84
GLY A  86
ILE A 111
ASP A 112
ASP A 135
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-3.7A)
None
SAM  A 400 (-3.4A)
0.71A 3grvA-2qe6A:
9.3
3grvA-2qe6A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 GLY A  84
GLY A  86
ASP A 135
ARG A 137
TYR A 168
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-3.4A)
SAM  A 400 (-4.6A)
SAM  A 400 ( 4.5A)
0.39A 3o7wA-2qe6A:
16.1
3o7wA-2qe6A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
3 / 3 TYR A  26
ASP A 110
ASP A 135
SAM  A 400 ( 3.8A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
0.70A 3ou6B-2qe6A:
13.4
3ou6B-2qe6A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
3 / 3 TYR A  26
GLY A  86
ASP A 110
SAM  A 400 ( 3.8A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-2.7A)
0.72A 3ou6C-2qe6A:
13.3
3ou6C-2qe6A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
3 / 3 GLY A  86
ASP A 110
ASP A 135
SAM  A 400 ( 3.2A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
0.33A 3ou7C-2qe6A:
13.2
3ou7C-2qe6A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 10 ASP A 110
GLY A  86
ASP A  82
VAL A 136
GLY A 164
SAM  A 400 (-2.7A)
SAM  A 400 ( 3.2A)
None
SAM  A 400 (-3.8A)
SAM  A 400 (-3.5A)
0.97A 3oxwA-2qe6A:
undetectable
3oxwA-2qe6A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 9 ILE A 160
LEU A 185
ILE A 268
PHE A 233
GLY A 231
None
1.16A 3sj4X-2qe6A:
undetectable
3sj4X-2qe6A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 11 GLY A  86
ASP A 110
ASP A 112
ASP A 135
VAL A 136
SAM  A 400 ( 3.2A)
SAM  A 400 (-2.7A)
None
SAM  A 400 (-3.4A)
SAM  A 400 (-3.8A)
0.86A 3v8vB-2qe6A:
10.1
3v8vB-2qe6A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 9 ASP A 110
GLY A  86
ASP A  82
VAL A 136
GLY A 164
SAM  A 400 (-2.7A)
SAM  A 400 ( 3.2A)
None
SAM  A 400 (-3.8A)
SAM  A 400 (-3.5A)
1.00A 4dqcB-2qe6A:
undetectable
4dqcB-2qe6A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 8 ILE A 160
LEU A 185
ILE A 268
PHE A 233
GLY A 231
None
1.25A 4hb8A-2qe6A:
undetectable
4hb8A-2qe6A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 VAL A 148
GLY A  84
ILE A 160
ARG A 137
LEU A 143
None
SAM  A 400 (-3.4A)
None
SAM  A 400 (-4.6A)
None
1.04A 4iv0A-2qe6A:
14.2
4iv0A-2qe6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 GLY A  84
GLY A  86
ASP A 110
ILE A 111
ASP A 135
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.7A)
SAM  A 400 (-3.4A)
0.47A 4iv8A-2qe6A:
14.1
4iv8A-2qe6A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 GLY A  84
GLY A  86
ASP A 110
ILE A 111
ASP A 135
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.7A)
SAM  A 400 (-3.4A)
0.48A 4iv8B-2qe6A:
14.1
4iv8B-2qe6A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 GLY A  84
GLY A  86
ILE A 111
ARG A 137
MET A 165
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-3.7A)
SAM  A 400 (-4.6A)
SAM  A 400 (-3.3A)
0.66A 4kicA-2qe6A:
15.0
4kicA-2qe6A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 GLY A  84
GLY A  86
ILE A 111
ARG A 137
MET A 165
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-3.7A)
SAM  A 400 (-4.6A)
SAM  A 400 (-3.3A)
0.65A 4kicB-2qe6A:
15.2
4kicB-2qe6A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
4 / 7 PRO A 238
VAL A 241
ALA A 266
TYR A 190
None
0.89A 4lb2A-2qe6A:
undetectable
4lb2A-2qe6A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
4 / 8 VAL A 109
LEU A  83
TYR A 181
VAL A 173
None
0.98A 4ma7A-2qe6A:
undetectable
4ma7A-2qe6A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
4 / 5 TYR A  26
THR A 129
LEU A 123
MET A 114
SAM  A 400 ( 3.8A)
None
MPD  A 403 (-4.2A)
None
1.21A 4mbsB-2qe6A:
undetectable
4mbsB-2qe6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 VAL A 148
GLY A  84
ILE A 160
ARG A 137
LEU A 143
None
SAM  A 400 (-3.4A)
None
SAM  A 400 (-4.6A)
None
1.05A 4mwzB-2qe6A:
14.0
4mwzB-2qe6A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 10 ASP A 110
GLY A  86
ASP A  82
VAL A 136
GLY A 164
SAM  A 400 (-2.7A)
SAM  A 400 ( 3.2A)
None
SAM  A 400 (-3.8A)
SAM  A 400 (-3.5A)
1.01A 4njtB-2qe6A:
undetectable
4njtB-2qe6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 ASP A  82
GLY A  84
THR A  93
ASP A 110
ASP A 135
None
SAM  A 400 (-3.4A)
None
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
1.18A 4pghB-2qe6A:
12.5
4pghB-2qe6A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
4 / 4 GLY A 164
LEU A  71
PHE A  70
ILE A 268
SAM  A 400 (-3.5A)
None
None
None
0.80A 4xv2A-2qe6A:
undetectable
4xv2A-2qe6A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 10 GLY A 179
VAL A 177
VAL A 178
LEU A 143
LEU A 162
None
1.26A 4yb6A-2qe6A:
undetectable
4yb6E-2qe6A:
undetectable
4yb6A-2qe6A:
23.31
4yb6E-2qe6A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 10 GLY A 179
VAL A 177
VAL A 178
LEU A 143
LEU A 162
None
1.27A 4yb6B-2qe6A:
undetectable
4yb6C-2qe6A:
undetectable
4yb6B-2qe6A:
23.31
4yb6C-2qe6A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 10 LEU A 143
LEU A 162
GLY A 179
VAL A 177
VAL A 178
None
1.27A 4yb6B-2qe6A:
undetectable
4yb6F-2qe6A:
undetectable
4yb6B-2qe6A:
23.31
4yb6F-2qe6A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
4 / 4 ASP A  82
GLY A  86
ASP A 110
ASP A 135
None
SAM  A 400 ( 3.2A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
0.65A 5e72A-2qe6A:
10.8
5e72A-2qe6A:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_A_RAUA400_1
(IMINE REDUCTASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 11 VAL A 177
LEU A 191
MET A 193
GLN A 229
GLY A 231
None
1.46A 5g6sA-2qe6A:
2.5
5g6sG-2qe6A:
2.5
5g6sA-2qe6A:
24.13
5g6sG-2qe6A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_B_RAUB400_1
(IMINE REDUCTASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 11 VAL A 177
LEU A 191
MET A 193
GLN A 229
GLY A 231
None
1.49A 5g6sB-2qe6A:
2.6
5g6sC-2qe6A:
2.6
5g6sB-2qe6A:
24.13
5g6sC-2qe6A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 GLN A 229
GLY A 231
VAL A 177
LEU A 191
MET A 193
None
1.45A 5g6sB-2qe6A:
2.6
5g6sC-2qe6A:
2.6
5g6sB-2qe6A:
24.13
5g6sC-2qe6A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_E_RAUE400_1
(IMINE REDUCTASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 11 VAL A 177
LEU A 191
MET A 193
GLN A 229
GLY A 231
None
1.46A 5g6sE-2qe6A:
2.7
5g6sH-2qe6A:
2.6
5g6sE-2qe6A:
24.13
5g6sH-2qe6A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_G_RAUG400_1
(IMINE REDUCTASE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 10 GLN A 229
GLY A 231
VAL A 177
LEU A 191
MET A 193
None
1.49A 5g6sA-2qe6A:
2.5
5g6sG-2qe6A:
2.6
5g6sA-2qe6A:
24.13
5g6sG-2qe6A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 11 ILE A 160
PHE A 154
LEU A 185
ALA A 186
VAL A 136
None
None
None
None
SAM  A 400 (-3.8A)
1.19A 5ji0A-2qe6A:
undetectable
5ji0A-2qe6A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 GLY A  84
GLY A  86
ASP A 110
ILE A 111
VAL A 136
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.7A)
SAM  A 400 (-3.8A)
0.46A 5wy0A-2qe6A:
12.6
5wy0A-2qe6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 GLY A  84
GLY A  86
ASP A 110
VAL A 136
LEU A 169
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.8A)
None
0.70A 5wy0A-2qe6A:
12.6
5wy0A-2qe6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
4 / 7 VAL A 240
VAL A  63
GLY A 264
TYR A 242
None
None
MPD  A 401 (-3.2A)
SO4  A 276 (-4.6A)
0.98A 5x80C-2qe6A:
undetectable
5x80D-2qe6A:
undetectable
5x80C-2qe6A:
21.51
5x80D-2qe6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 12 GLY A  84
ASP A 110
ILE A 111
ASP A 112
ASP A 135
SAM  A 400 (-3.4A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.7A)
None
SAM  A 400 (-3.4A)
0.44A 6bq4A-2qe6A:
9.1
6bq4A-2qe6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
6 / 12 GLY A  84
ASP A 110
ILE A 111
ASP A 112
VAL A 115
ASP A 135
SAM  A 400 (-3.4A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.7A)
None
MPD  A 403 ( 4.6A)
SAM  A 400 (-3.4A)
1.29A 6bq4B-2qe6A:
9.2
6bq4B-2qe6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
4 / 5 THR A  89
ARG A  61
THR A 129
ASP A 147
None
SAM  A 400 (-3.7A)
None
None
1.40A 6ecxA-2qe6A:
10.7
6ecxA-2qe6A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca)
5 / 11 GLY A  84
GLY A  86
ASP A 110
VAL A 115
ASP A 135
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-2.7A)
MPD  A 403 ( 4.6A)
SAM  A 400 (-3.4A)
1.21A 6i5zD-2qe6A:
12.6
6i5zD-2qe6A:
20.65