SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qe8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		4 / 6 ASP A 202
ASP A 255
ASN A 259
GLU A 241
 None
 1.32A 1rjdA-2qe8A:
undetectable		 1rjdA-2qe8A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		4 / 5 ILE A 147
ARG A 158
LEU A 110
PRO A  92
 None
 1.49A 1s8fA-2qe8A:
undetectable
1s8fB-2qe8A:
undetectable		 1s8fA-2qe8A:
18.88
1s8fB-2qe8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		4 / 6 ASP A 202
LEU A 201
VAL A 200
ILE A 199
 None
 0.89A 1s9qA-2qe8A:
undetectable		 1s9qA-2qe8A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		5 / 12 ILE A 240
ALA A 145
GLY A 162
GLY A 165
SER A 119
 None
GOL  A 350 ( 4.9A)
None
None
None
 1.19A 2okcB-2qe8A:
undetectable		 2okcB-2qe8A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		4 / 4 SER A 294
GLY A 251
GLY A  19
GLY A  70
 None
UNL  A 344 (-3.5A)
None
None
 0.90A 3bogB-2qe8A:
undetectable
3bogD-2qe8A:
undetectable		 3bogB-2qe8A:
undetectable
3bogD-2qe8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		5 / 12 GLY A 198
LEU A 194
PRO A 138
ASP A 293
TRP A 291
 UNL  A 344 (-3.6A)
GOL  A 346 ( 4.7A)
None
UNL  A 344 (-2.7A)
None
 1.18A 3i5uA-2qe8A:
undetectable		 3i5uA-2qe8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		5 / 12 GLY A 198
LEU A 194
PRO A 138
ASP A 293
TRP A 291
 UNL  A 344 (-3.6A)
GOL  A 346 ( 4.7A)
None
UNL  A 344 (-2.7A)
None
 1.17A 3i5uB-2qe8A:
undetectable		 3i5uB-2qe8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		5 / 12 PHE A 305
LEU A 173
ILE A 175
ALA A 269
SER A 268
 None
 1.25A 4a83A-2qe8A:
undetectable		 4a83A-2qe8A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		4 / 5 SER A 223
LYS A 222
LEU A 201
ASP A 202
 None
 1.43A 4ifxA-2qe8A:
undetectable		 4ifxA-2qe8A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		4 / 5 SER A 223
LYS A 222
LEU A 201
ASP A 202
 None
 1.42A 4ig1A-2qe8A:
undetectable		 4ig1A-2qe8A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		3 / 3 ARG A 148
ASP A 127
ASP A 202
 None
 0.89A 4kicB-2qe8A:
undetectable		 4kicB-2qe8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		4 / 6 LEU A 316
ASN A 317
MET A 213
LEU A 173
 UNL  A 344 ( 4.9A)
None
UNL  A 344 ( 4.2A)
None
 1.18A 4okbA-2qe8A:
undetectable		 4okbA-2qe8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		5 / 12 LEU A 124
ILE A 147
ILE A 114
VAL A 133
ILE A 135
 None
 0.90A 4q1xB-2qe8A:
undetectable		 4q1xB-2qe8A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		5 / 12 LEU A 124
ILE A 147
ILE A 114
VAL A 133
ILE A 135
 None
 0.94A 4q1yB-2qe8A:
undetectable		 4q1yB-2qe8A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		4 / 4 THR A 115
GLY A  85
ASP A  83
SER A 119
 None
 1.38A 4rfqA-2qe8A:
undetectable		 4rfqA-2qe8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		3 / 3 SER A 105
ASP A 123
ASP A  74
 GOL  A 349 (-2.7A)
UNL  A 344 (-3.7A)
GOL  A 349 ( 4.9A)
 0.78A 4uckA-2qe8A:
undetectable		 4uckA-2qe8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		4 / 5 SER A 223
LYS A 222
LEU A 201
ASP A 202
 None
 1.41A 4xdtA-2qe8A:
undetectable		 4xdtA-2qe8A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		4 / 8 PRO A 247
TYR A 280
SER A 290
SER A 211
 None
 1.11A 5l1fA-2qe8A:
undetectable
5l1fB-2qe8A:
undetectable		 5l1fA-2qe8A:
20.18
5l1fB-2qe8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		4 / 7 ASP A 250
GLY A  70
GLY A  19
HIS A  34
 UNL  A 344 (-2.6A)
None
None
UNL  A 344 (-4.2A)
 1.01A 5n9xA-2qe8A:
undetectable		 5n9xA-2qe8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		5 / 12 TRP A  80
ARG A 342
GLY A  75
GLY A 341
THR A  22
 GOL  A 349 ( 4.9A)
None
None
None
None
 1.23A 5o4yD-2qe8A:
undetectable
5o4yE-2qe8A:
undetectable		 5o4yD-2qe8A:
4.48
5o4yE-2qe8A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		4 / 7 ALA A 203
ILE A 252
PHE A 297
ILE A 221
 None
 0.88A 6b5vA-2qe8A:
undetectable
6b5vB-2qe8A:
undetectable		 6b5vA-2qe8A:
13.16
6b5vB-2qe8A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		5 / 12 LEU A 283
ASP A 306
GLY A 251
ILE A 252
ILE A 270
 None
None
UNL  A 344 (-3.5A)
None
None
 1.06A 6difA-2qe8A:
undetectable		 6difA-2qe8A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 2qe8 UNCHARACTERIZED
PROTEIN
(Trichormus
variabilis) 		3 / 3 LYS A  93
VAL A  91
ASP A  83
 None
 0.70A 6fgdA-2qe8A:
undetectable		 6fgdA-2qe8A:
23.43