SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES
(Corynebacterium
glutamicum) 		5 / 9 ALA A   8
ASP A  63
VAL A  75
VAL A  17
ILE A  16
 EDO  A 205 (-3.9A)
EDO  A 210 (-3.5A)
None
None
None
 1.13A 1hpvB-2qecA:
undetectable		 1hpvB-2qecA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES
(Corynebacterium
glutamicum) 		5 / 12 GLY A 138
LEU A 174
VAL A 141
ALA A 144
LEU A 170
 EDO  A 211 (-3.3A)
None
None
None
None
 1.44A 1jipA-2qecA:
undetectable		 1jipA-2qecA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES
(Corynebacterium
glutamicum) 		3 / 3 ASP A  79
TYR A 128
GLU A 161
 None
 0.87A 1vm1A-2qecA:
undetectable		 1vm1A-2qecA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES
(Corynebacterium
glutamicum) 		4 / 5 PHE A  24
PHE A  48
LEU A  47
PHE A 101
 None
 1.21A 2y69C-2qecA:
undetectable
2y69J-2qecA:
undetectable		 2y69C-2qecA:
20.22
2y69J-2qecA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES
(Corynebacterium
glutamicum) 		4 / 5 PHE A  24
PHE A  48
LEU A  47
PHE A 101
 None
 1.23A 2y69P-2qecA:
undetectable
2y69W-2qecA:
undetectable		 2y69P-2qecA:
20.22
2y69W-2qecA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES
(Corynebacterium
glutamicum) 		4 / 5 PHE A  24
PHE A  48
LEU A  47
PHE A 101
 None
 1.23A 3abmC-2qecA:
undetectable
3abmJ-2qecA:
undetectable		 3abmC-2qecA:
20.22
3abmJ-2qecA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES
(Corynebacterium
glutamicum) 		4 / 5 PHE A  24
PHE A  48
LEU A  47
PHE A 101
 None
 1.23A 3abmP-2qecA:
undetectable
3abmW-2qecA:
undetectable		 3abmP-2qecA:
20.22
3abmW-2qecA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES
(Corynebacterium
glutamicum) 		4 / 5 PHE A  24
PHE A  48
LEU A  47
PHE A 101
 None
 1.22A 3ag3C-2qecA:
undetectable
3ag3J-2qecA:
undetectable		 3ag3C-2qecA:
20.22
3ag3J-2qecA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES
(Corynebacterium
glutamicum) 		5 / 10 ALA A   8
ASP A  63
VAL A  75
VAL A  17
ILE A  16
 EDO  A 205 (-3.9A)
EDO  A 210 (-3.5A)
None
None
None
 1.08A 4dqcA-2qecA:
undetectable		 4dqcA-2qecA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES
(Corynebacterium
glutamicum) 		5 / 9 ALA A   8
ASP A  63
VAL A  75
VAL A  17
ILE A  16
 EDO  A 205 (-3.9A)
EDO  A 210 (-3.5A)
None
None
None
 1.13A 4ll3B-2qecA:
undetectable		 4ll3B-2qecA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES
(Corynebacterium
glutamicum) 		5 / 11 TYR A 171
LEU A 170
ILE A 150
ALA A  76
PHE A 176
 None
None
EDO  A 208 (-4.3A)
None
None
 1.17A 5gpgA-2qecA:
undetectable		 5gpgA-2qecA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES
(Corynebacterium
glutamicum) 		4 / 5 PHE A  24
PHE A  48
LEU A  47
PHE A 101
 None
 1.20A 5wauC-2qecA:
undetectable
5wauJ-2qecA:
undetectable		 5wauC-2qecA:
20.22
5wauJ-2qecA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES
(Corynebacterium
glutamicum) 		5 / 10 VAL A 141
GLY A 140
ALA A  65
LEU A 145
ASN A 147
 None
 0.94A 5x6yB-2qecA:
undetectable		 5x6yB-2qecA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES
(Corynebacterium
glutamicum) 		4 / 5 PHE A  24
PHE A  48
LEU A  47
PHE A 101
 None
 1.23A 5xdqC-2qecA:
undetectable
5xdqJ-2qecA:
undetectable		 5xdqC-2qecA:
20.22
5xdqJ-2qecA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qec HISTONE
ACETYLTRANSFERASE
HPA2 AND RELATED
ACETYLTRANSFERASES
(Corynebacterium
glutamicum) 		4 / 5 PHE A  24
PHE A  48
LEU A  47
PHE A 101
 None
 1.23A 5xdqP-2qecA:
undetectable
5xdqW-2qecA:
undetectable		 5xdqP-2qecA:
20.22
5xdqW-2qecA:
17.92