SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qen'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2qen WALKER-TYPE ATPASE
(Pyrococcus
abyssi) 		4 / 8 LEU A 190
ILE A 183
GLU A 197
ILE A 167
 None
 0.94A 2azxA-2qenA:
undetectable		 2azxA-2qenA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 2qen WALKER-TYPE ATPASE
(Pyrococcus
abyssi) 		5 / 10 LEU A  37
LEU A  35
LEU A 181
LYS A 182
LEU A 177
 None
 1.16A 2xn6A-2qenA:
undetectable
2xn6B-2qenA:
undetectable		 2xn6A-2qenA:
23.50
2xn6B-2qenA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2qen WALKER-TYPE ATPASE
(Pyrococcus
abyssi) 		5 / 12 ALA A  50
PRO A 202
PHE A 203
GLY A  43
LEU A  48
 None
None
None
ADP  A 999 (-3.3A)
None
 0.89A 2zifA-2qenA:
3.8		 2zifA-2qenA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2qen WALKER-TYPE ATPASE
(Pyrococcus
abyssi) 		5 / 12 LEU A  65
PHE A 117
ILE A  85
ILE A 167
LEU A 165
 None
 1.17A 3w67D-2qenA:
3.5		 3w67D-2qenA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 2qen WALKER-TYPE ATPASE
(Pyrococcus
abyssi) 		5 / 10 LEU A 140
LEU A 151
VAL A 132
LEU A 165
LEU A 120
 None
 0.84A 4po0A-2qenA:
undetectable		 4po0A-2qenA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 2qen WALKER-TYPE ATPASE
(Pyrococcus
abyssi) 		4 / 6 LEU A 250
LEU A 212
PHE A 245
THR A 262
 None
 1.11A 4udaA-2qenA:
undetectable		 4udaA-2qenA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qen WALKER-TYPE ATPASE
(Pyrococcus
abyssi) 		4 / 8 ILE A  60
SER A  86
LEU A 101
LEU A 123
 None
 0.98A 4xtaB-2qenA:
undetectable		 4xtaB-2qenA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 2qen WALKER-TYPE ATPASE
(Pyrococcus
abyssi) 		6 / 12 ARG A 297
LEU A 300
ALA A 290
ASP A 286
ILE A 287
ILE A 301
 None
 1.44A 5e5jB-2qenA:
undetectable		 5e5jB-2qenA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2qen WALKER-TYPE ATPASE
(Pyrococcus
abyssi) 		3 / 3 PHE A 180
ASP A 179
LYS A 182
 None
 0.84A 6awtD-2qenA:
undetectable		 6awtD-2qenA:
21.70