SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qep'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens) 		4 / 7 TYR A 868
TYR A 857
TRP A 860
GLN A 905
 None
 1.40A 1eiiA-2qepA:
0.7		 1eiiA-2qepA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens) 		4 / 8 PHE A 997
ILE A 958
LEU A 962
GLU A1005
 None
 0.82A 1eupA-2qepA:
undetectable		 1eupA-2qepA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens) 		4 / 8 PHE A 997
ILE A 958
PRO A 917
LEU A 923
 None
 0.73A 1hmyA-2qepA:
undetectable		 1hmyA-2qepA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens) 		5 / 12 LEU A 789
ILE A 817
THR A 819
ASP A 829
LEU A 892
 None
 1.17A 2jn3A-2qepA:
undetectable		 2jn3A-2qepA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens) 		3 / 3 ASN A 774
ASN A 802
ARG A 985
 None
 0.72A 2rlcA-2qepA:
undetectable		 2rlcA-2qepA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens) 		3 / 3 ARG A 786
ASP A 829
ASN A 770
 None
 0.71A 2zzmA-2qepA:
undetectable		 2zzmA-2qepA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens) 		4 / 5 VAL A 843
VAL A 943
PHE A 885
ARG A 775
 None
 1.37A 3bjwH-2qepA:
undetectable		 3bjwH-2qepA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens) 		4 / 5 PRO A 805
ILE A 817
PRO A 940
TYR A 816
 None
 1.05A 3d9lA-2qepA:
undetectable
3d9lY-2qepA:
undetectable		 3d9lA-2qepA:
19.67
3d9lY-2qepA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens) 		4 / 5 HIS A 784
ASP A 783
TYR A 782
PRO A 986
 None
 1.29A 3fo7A-2qepA:
undetectable		 3fo7A-2qepA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens) 		4 / 5 HIS A 784
ASP A 783
TYR A 782
PRO A 986
 None
 1.27A 3h1xA-2qepA:
undetectable		 3h1xA-2qepA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens) 		4 / 7 VAL A 873
VAL A 827
PHE A 830
ILE A 842
 None
 0.96A 3zjqA-2qepA:
undetectable		 3zjqA-2qepA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens) 		4 / 7 VAL A 873
VAL A 827
PHE A 830
ILE A 842
 None
 0.98A 3zjqB-2qepA:
undetectable		 3zjqB-2qepA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens) 		3 / 3 ARG A 982
LEU A 978
GLU A 979
 None
 0.74A 4l3gF-2qepA:
undetectable		 4l3gF-2qepA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens) 		4 / 4 SER A 796
SER A 798
GLU A 836
ASP A 829
 None
 1.44A 4ymgA-2qepA:
0.0		 4ymgA-2qepA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens) 		4 / 8 TYR A 859
THR A 819
CYH A 839
TRP A 831
 None
 1.13A 6cnjD-2qepA:
undetectable
6cnjE-2qepA:
undetectable		 6cnjD-2qepA:
15.38
6cnjE-2qepA:
14.72