SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qeq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
2qeq FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT

(West
Nile
virus)
5 / 12 PHE A 614
ALA A 541
ALA A 548
CYH A 564
ARG A 561
None
1.08A 2qm9A-2qeqA:
undetectable
2qm9A-2qeqA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)
2qeq FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT

(West
Nile
virus)
4 / 6 LEU A 376
SER A 421
ASP A 471
LYS A 381
None
1.34A 2vn1B-2qeqA:
undetectable
2vn1B-2qeqA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)
2qeq FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT

(West
Nile
virus)
4 / 7 THR A 408
VAL A 423
ASP A 425
VAL A 360
None
0.93A 4cp4A-2qeqA:
undetectable
4cp4A-2qeqA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)
2qeq FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT

(West
Nile
virus)
4 / 5 ILE A 313
ILE A 209
VAL A 283
THR A 219
None
0.71A 4xdtA-2qeqA:
undetectable
4xdtA-2qeqA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
2qeq FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT

(West
Nile
virus)
5 / 11 SER A 454
THR A 451
ALA A 492
GLU A 515
THR A 318
None
1.46A 4zjoD-2qeqA:
undetectable
4zjoD-2qeqA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
2qeq FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT

(West
Nile
virus)
3 / 3 GLU A 354
TYR A 355
ARG A 422
None
0.83A 5uunB-2qeqA:
undetectable
5uunB-2qeqA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)
2qeq FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT

(West
Nile
virus)
3 / 3 GLU A 371
LEU A 374
ARG A 378
None
0.67A 6d8fA-2qeqA:
2.7
6d8fA-2qeqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2qeq FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT

(West
Nile
virus)
4 / 6 ILE A 499
LEU A 496
ARG A 269
THR A 265
None
1.00A 6nmfN-2qeqA:
undetectable
6nmfW-2qeqA:
undetectable
6nmfN-2qeqA:
21.49
6nmfW-2qeqA:
8.76