SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qes'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		5 / 9 PHE A  89
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 ADE  A 501 ( 4.9A)
ADE  A 501 (-3.7A)
ADE  A 501 (-4.0A)
ADE  A 501 ( 4.7A)
ADE  A 501 (-2.9A)
 0.28A 1mrgA-2qesA:
30.8		 1mrgA-2qesA:
30.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		4 / 8 TYR A 122
ILE A 170
GLU A 175
ARG A 178
 ADE  A 501 (-3.7A)
ADE  A 501 (-4.0A)
ADE  A 501 ( 4.7A)
ADE  A 501 (-2.9A)
 0.18A 1mrjA-2qesA:
30.6		 1mrjA-2qesA:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		4 / 8 TYR A 122
ILE A 170
SER A 174
GLU A 175
 ADE  A 501 (-3.7A)
ADE  A 501 (-4.0A)
ADE  A 501 (-3.6A)
ADE  A 501 ( 4.7A)
 0.67A 1mrjA-2qesA:
30.6		 1mrjA-2qesA:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		4 / 6 PHE A  89
ASN A  90
ARG A  67
ASN A  70
 ADE  A 501 ( 4.9A)
None
None
None
 1.36A 1t9uA-2qesA:
0.0		 1t9uA-2qesA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		4 / 6 VAL A 154
VAL A   8
ILE A 141
ASP A 147
 None
 0.87A 1uwhB-2qesA:
undetectable		 1uwhB-2qesA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		5 / 12 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
 None
 1.09A 1xdkA-2qesA:
undetectable		 1xdkA-2qesA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		4 / 6 ASN A 197
TYR A 122
GLU A 175
ILE A 182
 None
ADE  A 501 (-3.7A)
ADE  A 501 ( 4.7A)
None
 1.08A 3q5sA-2qesA:
undetectable		 3q5sA-2qesA:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		4 / 5 TYR A  72
TYR A 122
ILE A 170
ARG A 178
 ADE  A 501 (-3.8A)
ADE  A 501 (-3.7A)
ADE  A 501 (-4.0A)
ADE  A 501 (-2.9A)
 0.55A 4o0oA-2qesA:
31.2		 4o0oA-2qesA:
30.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		3 / 3 GLU A 175
ALA A 176
PHE A 179
 ADE  A 501 ( 4.7A)
None
None
 0.63A 4v1fA-2qesA:
undetectable		 4v1fA-2qesA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		3 / 3 GLU A 175
ALA A 176
PHE A 179
 ADE  A 501 ( 4.7A)
None
None
 0.60A 4v1fC-2qesA:
undetectable		 4v1fC-2qesA:
16.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		6 / 9 TYR A  72
PHE A  89
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 ADE  A 501 (-3.8A)
ADE  A 501 ( 4.9A)
ADE  A 501 (-3.7A)
ADE  A 501 (-4.0A)
ADE  A 501 ( 4.7A)
ADE  A 501 (-2.9A)
 0.24A 4yp2B-2qesA:
31.2		 4yp2B-2qesA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		6 / 9 TYR A  72
PHE A  89
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 ADE  A 501 (-3.8A)
ADE  A 501 ( 4.9A)
ADE  A 501 (-3.7A)
ADE  A 501 (-4.0A)
ADE  A 501 ( 4.7A)
ADE  A 501 (-2.9A)
 0.24A 5cf9B-2qesA:
31.3		 5cf9B-2qesA:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		5 / 11 GLY A 140
ALA A 176
VAL A 186
GLU A 204
ILE A 141
 None
 1.23A 5i3cC-2qesA:
undetectable		 5i3cC-2qesA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		5 / 10 PRO A  38
ILE A 210
LEU A 250
PHE A 179
GLU A 183
 None
 1.36A 5tixB-2qesA:
undetectable		 5tixB-2qesA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		6 / 6 TYR A  72
VAL A  73
TYR A 122
ILE A 170
GLU A 175
ARG A 178
 ADE  A 501 (-3.8A)
ADE  A 501 ( 3.9A)
ADE  A 501 (-3.7A)
ADE  A 501 (-4.0A)
ADE  A 501 ( 4.7A)
ADE  A 501 (-2.9A)
 0.24A 5z3jA-2qesA:
32.3		 5z3jA-2qesA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		5 / 12 ILE A   4
TYR A  16
ARG A  24
ALA A 177
LEU A 250
 None
 1.24A 5zwrA-2qesA:
undetectable		 5zwrA-2qesA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4
(Phytolacca
dioica) 		4 / 6 GLY A   9
ASN A 145
ASP A  56
SER A  58
 None
 1.20A 6dwdA-2qesA:
undetectable
6dwdC-2qesA:
undetectable		 6dwdA-2qesA:
19.08
6dwdC-2qesA:
19.08