SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qeu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 2qeu PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE
(Paraburkholderia
xenovorans) 		5 / 12 ILE A  12
ALA A  44
LEU A  34
PHE A  42
LEU A  27
 None
 1.22A 1ddrB-2qeuA:
undetectable		 1ddrB-2qeuA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 2qeu PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE
(Paraburkholderia
xenovorans) 		5 / 12 ILE A  12
ALA A  44
LEU A  34
PHE A  42
LEU A  27
 None
 1.19A 1jolA-2qeuA:
undetectable		 1jolA-2qeuA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2qeu PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE
(Paraburkholderia
xenovorans) 		3 / 3 VAL A  98
ASP A  99
GLU A 132
 ACT  A 141 ( 4.5A)
ACT  A 141 (-3.7A)
ACT  A 141 (-3.6A)
 0.00A 2qeuA-2qeuA:
26.9		 2qeuA-2qeuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2qeu PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE
(Paraburkholderia
xenovorans) 		4 / 5 GLU A  80
PRO A  81
ILE A  82
GLY A  83
 CIT  A 146 ( 3.0A)
ACT  A 142 (-3.5A)
ACT  A 142 (-3.9A)
ACT  A 142 ( 3.1A)
 0.00A 2qeuA-2qeuA:
26.9
2qeuC-2qeuA:
25.2		 2qeuA-2qeuA:
100.00
2qeuC-2qeuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2qeu PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE
(Paraburkholderia
xenovorans) 		3 / 3 PRO A  28
ASN A  86
ARG A  89
 ACT  A 145 (-3.8A)
ACT  A 145 (-3.1A)
ACT  A 145 ( 4.7A)
 0.23A 2qeuB-2qeuA:
25.1		 2qeuB-2qeuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2qeu PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE
(Paraburkholderia
xenovorans) 		3 / 3 VAL A  98
ASP A  99
GLU A 132
 ACT  A 141 ( 4.5A)
ACT  A 141 (-3.7A)
ACT  A 141 (-3.6A)
 0.05A 2qeuC-2qeuA:
25.2		 2qeuC-2qeuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 2qeu PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE
(Paraburkholderia
xenovorans) 		3 / 3 MET A  92
VAL A  72
GLU A 100
 None
 0.90A 3c6gA-2qeuA:
undetectable		 3c6gA-2qeuA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 2qeu PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE
(Paraburkholderia
xenovorans) 		4 / 5 LEU A  31
SER A  46
LEU A  27
PRO A  28
 None
None
None
ACT  A 145 (-3.8A)
 1.34A 3onnA-2qeuA:
undetectable		 3onnA-2qeuA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2qeu PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE
(Paraburkholderia
xenovorans) 		4 / 7 VAL A  85
ILE A  82
ASN A  86
GLU A 134
 None
ACT  A 142 (-3.9A)
ACT  A 145 (-3.1A)
None
 1.07A 4a97E-2qeuA:
2.8		 4a97E-2qeuA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2qeu PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE
(Paraburkholderia
xenovorans) 		5 / 11 ILE A  12
ALA A  44
LEU A  34
PHE A  42
LEU A  27
 None
 1.18A 4i1nA-2qeuA:
undetectable		 4i1nA-2qeuA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2qeu PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE
(Paraburkholderia
xenovorans) 		5 / 11 ILE A  12
ALA A  44
LEU A  34
PHE A  42
LEU A  27
 None
 1.21A 4qlfA-2qeuA:
undetectable		 4qlfA-2qeuA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 2qeu PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE
(Paraburkholderia
xenovorans) 		3 / 3 ARG A  49
GLU A  80
TYR A  45
 CIT  A 146 (-3.8A)
CIT  A 146 ( 3.0A)
CIT  A 146 (-4.7A)
 0.96A 4r29D-2qeuA:
undetectable		 4r29D-2qeuA:
21.55