SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		4 / 5 PHE A 314
GLY A 262
THR A 256
PHE A 260
 None
 1.25A 1icuC-2qezA:
undetectable
1icuD-2qezA:
undetectable		 1icuC-2qezA:
18.64
1icuD-2qezA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		4 / 5 PHE A 314
GLY A 262
THR A 256
PHE A 260
 None
 1.34A 1icvA-2qezA:
undetectable
1icvB-2qezA:
undetectable		 1icvA-2qezA:
18.64
1icvB-2qezA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		5 / 10 ILE A 357
GLY A 352
GLU A 287
GLY A 289
GLU A 308
 None
 1.29A 1mehA-2qezA:
8.2		 1mehA-2qezA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		5 / 10 LEU A  96
GLU A  94
LEU A 128
ILE A 122
LEU A  59
 None
 1.27A 1pcgA-2qezA:
undetectable		 1pcgA-2qezA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		5 / 12 GLY A 184
GLY A 180
GLN A 429
ASP A 428
SER A 437
 None
 1.20A 1wg8B-2qezA:
undetectable		 1wg8B-2qezA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		4 / 5 SER A 247
GLY A 291
GLU A 287
CYH A 311
 None
 0.91A 3aiaA-2qezA:
undetectable
3aiaB-2qezA:
undetectable		 3aiaA-2qezA:
19.69
3aiaB-2qezA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		5 / 12 ALA A 138
PHE A 157
PHE A 419
GLY A 360
LEU A 379
 None
None
GOL  A 455 ( 4.9A)
None
None
 1.38A 3aodC-2qezA:
undetectable		 3aodC-2qezA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		3 / 3 LYS A  28
ILE A 391
PHE A 390
 None
 0.97A 3j7zS-2qezA:
undetectable
3j7za-2qezA:
undetectable		 3j7zS-2qezA:
15.14
3j7za-2qezA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		4 / 7 PHE A 258
GLY A 259
PHE A 260
CYH A 311
 None
 1.11A 3ko0D-2qezA:
undetectable
3ko0E-2qezA:
undetectable		 3ko0D-2qezA:
12.50
3ko0E-2qezA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		3 / 3 ARG A  44
LYS A  48
ARG A 343
 None
 1.37A 3w1wA-2qezA:
0.0
3w1wB-2qezA:
0.0		 3w1wA-2qezA:
21.52
3w1wB-2qezA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		3 / 3 ARG A 343
ARG A  44
LYS A  48
 None
 1.48A 3w1wA-2qezA:
0.0
3w1wB-2qezA:
0.0		 3w1wA-2qezA:
21.52
3w1wB-2qezA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		3 / 3 ARG A  44
GLU A  43
PHE A  14
 None
 0.90A 4kszA-2qezA:
undetectable		 4kszA-2qezA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		4 / 8 GLY A 345
GLU A 308
ALA A 309
MET A 351
 None
 0.88A 4rjdA-2qezA:
0.0
4rjdB-2qezA:
0.0		 4rjdA-2qezA:
11.64
4rjdB-2qezA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		3 / 3 VAL A 323
TYR A 312
ALA A 315
 None
 0.44A 4ybnA-2qezA:
undetectable		 4ybnA-2qezA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		4 / 8 THR A 220
THR A 222
PRO A 163
LEU A 161
 None
 0.96A 5g48A-2qezA:
undetectable		 5g48A-2qezA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_D_EVPD102_1
(DNA TOPOISOMERASE
2-ALPHA)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		4 / 4 GLY A 186
ASP A 187
ARG A 160
MET A 235
 None
 1.29A 5gwkB-2qezA:
0.0		 5gwkB-2qezA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		4 / 6 CYH A 361
LEU A 379
CYH A 388
LEU A 383
 None
 1.16A 5hpuC-2qezA:
undetectable
5hpuD-2qezA:
undetectable		 5hpuC-2qezA:
4.62
5hpuD-2qezA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		4 / 5 THR A 230
HIS A 227
ALA A 226
ASP A 197
 None
 1.43A 5mfxA-2qezA:
undetectable		 5mfxA-2qezA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		3 / 3 LEU A 379
ILE A 342
TYR A 336
 None
 0.67A 5uunB-2qezA:
undetectable		 5uunB-2qezA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		5 / 12 TYR A 312
GLY A 345
GLY A 352
ASN A 131
ASP A 348
 None
 1.12A 5yn6A-2qezA:
undetectable		 5yn6A-2qezA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		5 / 12 TYR A 312
GLY A 345
GLY A 352
ASN A 131
ASP A 348
 None
 1.09A 5yniA-2qezA:
undetectable		 5yniA-2qezA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		5 / 12 TYR A 312
GLY A 345
GLY A 352
ASN A 131
ASP A 348
 None
 1.10A 5ynmA-2qezA:
undetectable		 5ynmA-2qezA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		5 / 12 HIS A 227
VAL A 244
VAL A  72
THR A 256
GLY A 259
 None
 1.20A 6brdA-2qezA:
undetectable		 6brdA-2qezA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		5 / 12 LEU A 322
ARG A 416
MET A 392
PHE A 321
THR A 220
 None
 1.44A 6brdA-2qezA:
undetectable		 6brdA-2qezA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		4 / 6 ALA A 449
GLY A 184
ILE A 190
PHE A 209
 None
 0.80A 6f8cA-2qezA:
undetectable		 6f8cA-2qezA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Listeria
monocytogenes) 		5 / 11 GLY A 313
SER A 119
ALA A 123
ASN A 255
VAL A  72
 None
 0.99A 6hu9A-2qezA:
undetectable
6hu9E-2qezA:
0.1
6hu9I-2qezA:
undetectable		 6hu9A-2qezA:
23.00
6hu9E-2qezA:
18.44
6hu9I-2qezA:
10.19