SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qf7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		3 / 3 ALA A 869
VAL A 864
TRP A 861
 None
 0.84A 1av2C-2qf7A:
undetectable
1av2D-2qf7A:
undetectable		 1av2C-2qf7A:
2.25
1av2D-2qf7A:
2.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 8 ASP A 563
ARG A 558
TYR A 821
THR A1009
 None
 1.48A 1ceaA-2qf7A:
undetectable
1ceaB-2qf7A:
undetectable		 1ceaA-2qf7A:
5.56
1ceaB-2qf7A:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 ILE A 381
ALA A 376
GLN A 351
ILE A 442
LEU A 350
 None
 1.04A 1dhfA-2qf7A:
undetectable		 1dhfA-2qf7A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 ILE A 381
ALA A 376
GLN A 351
ILE A 442
LEU A 350
 None
 1.07A 1dhfB-2qf7A:
undetectable		 1dhfB-2qf7A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 ILE A 381
ALA A 376
GLN A 351
ILE A 442
LEU A 350
 None
 1.11A 1dlsA-2qf7A:
undetectable		 1dlsA-2qf7A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 ILE A 381
ALA A 376
GLN A 351
ILE A 442
LEU A 350
 None
 1.07A 1drfA-2qf7A:
undetectable		 1drfA-2qf7A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 GLY A 622
ASN A 662
SER A 920
PHE A 654
VAL A 653
 None
None
None
KCX  A 718 ( 4.2A)
None
 1.02A 1ffyA-2qf7A:
undetectable		 1ffyA-2qf7A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 7 HIS A 749
LEU A 554
SER A 553
ASP A 549
 ZN  A1157 (-3.3A)
None
None
ZN  A1157 (-2.6A)
 1.18A 1ismB-2qf7A:
undetectable		 1ismB-2qf7A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 7 GLU A 248
PHE A 426
MET A 419
ALA A 415
 None
 1.33A 1linA-2qf7A:
undetectable		 1linA-2qf7A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		3 / 3 ALA A 869
VAL A 864
TRP A 861
 None
 0.87A 1w5uC-2qf7A:
undetectable
1w5uD-2qf7A:
undetectable		 1w5uC-2qf7A:
2.25
1w5uD-2qf7A:
2.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 6 TYR A 987
GLY A 622
SER A 666
ARG A 621
 None
 1.29A 2a3cA-2qf7A:
8.3		 2a3cA-2qf7A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 6 TYR A 987
GLY A 622
SER A 666
ARG A 621
 None
 1.27A 2a3cB-2qf7A:
7.5		 2a3cB-2qf7A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 11 THR A 588
ALA A 643
PRO A 600
ALA A 982
PHE A 651
 None
 0.97A 2admA-2qf7A:
undetectable		 2admA-2qf7A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 11 THR A 588
ALA A 643
PRO A 600
ALA A 982
PHE A 651
 None
 0.98A 2admB-2qf7A:
2.8		 2admB-2qf7A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 ALA A  85
ASP A  84
ILE A 322
ILE A  27
ILE A 111
 None
 0.84A 2b60A-2qf7A:
undetectable		 2b60A-2qf7A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 LEU A 575
GLU A 791
GLY A 787
SER A 794
ALA A 776
 None
 1.30A 2bm9B-2qf7A:
4.2		 2bm9B-2qf7A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 8 SER A 238
VAL A 217
PRO A 253
TYR A 452
 None
 0.86A 2ddwA-2qf7A:
undetectable		 2ddwA-2qf7A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 ALA A  85
ASP A  84
ILE A 322
ILE A  27
ILE A 111
 None
 0.73A 2hs1A-2qf7A:
undetectable		 2hs1A-2qf7A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		3 / 3 LEU A 620
MET A 618
MET A 720
 None
None
KCX  A 718 ( 3.6A)
 0.88A 2vavF-2qf7A:
undetectable		 2vavF-2qf7A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 ILE A 381
ALA A 376
GLN A 351
ILE A 442
LEU A 350
 None
 1.12A 2w3mA-2qf7A:
undetectable		 2w3mA-2qf7A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 8 TYR A 700
LEU A 697
LEU A 732
ALA A 728
 None
 0.94A 2wekA-2qf7A:
4.5		 2wekA-2qf7A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 7 TYR A 631
VAL A 626
TYR A 628
TYR A 987
 None
 1.34A 2xz5B-2qf7A:
undetectable
2xz5E-2qf7A:
undetectable		 2xz5B-2qf7A:
10.06
2xz5E-2qf7A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 7 TYR A 631
VAL A 626
TYR A 628
TYR A 987
 None
 1.34A 2xz5D-2qf7A:
undetectable
2xz5E-2qf7A:
undetectable		 2xz5D-2qf7A:
10.06
2xz5E-2qf7A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 11 VAL A 230
LEU A 222
GLY A 223
ILE A 277
LYS A   1
 None
 1.10A 3bjwB-2qf7A:
undetectable		 3bjwB-2qf7A:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 11 VAL A 230
LEU A 222
GLY A 223
ILE A 277
LYS A   1
 None
 1.15A 3bjwE-2qf7A:
undetectable		 3bjwE-2qf7A:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 VAL A 230
LEU A 222
GLY A 223
ILE A 277
LYS A   1
 None
 1.11A 3bjwF-2qf7A:
undetectable		 3bjwF-2qf7A:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		3 / 3 PRO A 883
PHE A 875
LYS A 880
 None
 1.28A 3bjwG-2qf7A:
undetectable		 3bjwG-2qf7A:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		3 / 3 GLY A 801
ASP A 799
SER A 794
 None
 0.61A 3brfA-2qf7A:
undetectable		 3brfA-2qf7A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 4 PRO A 831
THR A 751
GLY A 550
THR A 546
 None
 0.99A 3ib1A-2qf7A:
2.0		 3ib1A-2qf7A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 5 SER A 826
ARG A 548
GLY A 550
GLU A 582
 None
KCX  A 718 ( 3.6A)
None
None
 1.34A 3k9fA-2qf7A:
undetectable
3k9fB-2qf7A:
undetectable
3k9fC-2qf7A:
undetectable		 3k9fA-2qf7A:
18.66
3k9fB-2qf7A:
18.66
3k9fC-2qf7A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 ALA A1024
LEU A1007
LEU A 480
LEU A1016
ILE A1034
 None
 1.07A 3uvvA-2qf7A:
undetectable		 3uvvA-2qf7A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 6 ILE A 270
TYR A 284
HIS A 216
VAL A 211
 None
None
AGS  A1162 (-3.9A)
AGS  A1162 ( 4.6A)
 1.23A 4a97I-2qf7A:
undetectable		 4a97I-2qf7A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 8 TYR A 631
VAL A 626
TYR A 628
TYR A 987
 None
 1.26A 4bqtC-2qf7A:
undetectable
4bqtD-2qf7A:
undetectable		 4bqtC-2qf7A:
10.24
4bqtD-2qf7A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 6 SER A 998
ASP A 999
ARG A 974
GLU A 980
 None
 0.95A 4eysA-2qf7A:
2.6		 4eysA-2qf7A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 8 ARG A  17
GLN A 220
GLY A 280
THR A 281
 None
 0.99A 4k87A-2qf7A:
3.0		 4k87A-2qf7A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 ILE A 381
ALA A 376
GLN A 351
ILE A 442
LEU A 350
 None
 1.10A 4kebB-2qf7A:
undetectable		 4kebB-2qf7A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 GLN A 783
ASP A 719
HIS A 747
SER A 553
LEU A 554
 ZN  A1157 ( 4.5A)
None
ZN  A1157 (-3.3A)
None
None
 1.34A 4kmuC-2qf7A:
4.2		 4kmuC-2qf7A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 GLN A 783
ASP A 719
HIS A 747
SER A 553
LEU A 554
 ZN  A1157 ( 4.5A)
None
ZN  A1157 (-3.3A)
None
None
 1.38A 4kmuH-2qf7A:
5.6		 4kmuH-2qf7A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 7 SER A 238
TYR A 452
ARG A 249
VAL A 217
 None
 1.47A 4l64A-2qf7A:
8.7		 4l64A-2qf7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 7 TYR A 700
ILE A 744
ILE A 715
ALA A 704
 None
 0.89A 4lv9A-2qf7A:
2.4		 4lv9A-2qf7A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 7 TYR A 700
ILE A 744
ILE A 715
ALA A 704
 None
 0.88A 4lv9B-2qf7A:
2.4		 4lv9B-2qf7A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		6 / 7 LYS A 245
ASN A 299
ARG A 301
GLN A 303
VAL A 304
GLU A 305
 AGS  A1162 (-3.5A)
AGS  A1162 ( 3.7A)
None
None
None
None
 0.84A 4mv7A-2qf7A:
54.8		 4mv7A-2qf7A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 5 ILE A1034
ARG A 429
ASP A 471
VAL A1006
 None
 0.84A 4nkxC-2qf7A:
undetectable		 4nkxC-2qf7A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 5 ILE A1034
ARG A 429
ASP A 471
VAL A1006
 None
 0.85A 4nkxD-2qf7A:
undetectable		 4nkxD-2qf7A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 7 LEU A1136
ILE A1115
ILE A1095
VAL A1113
 None
 0.86A 4ojbA-2qf7A:
undetectable		 4ojbA-2qf7A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 5 HIS A 216
VAL A 217
GLU A 218
LYS A 245
 AGS  A1162 (-3.9A)
None
None
AGS  A1162 (-3.5A)
 1.04A 4p6vB-2qf7A:
3.7
4p6vE-2qf7A:
undetectable		 4p6vB-2qf7A:
16.28
4p6vE-2qf7A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 GLU A 602
ASP A 599
LEU A 616
ALA A 982
PHE A 979
 None
 1.06A 4retC-2qf7A:
2.9		 4retC-2qf7A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 ILE A 681
ALA A 728
HIS A 747
VAL A 717
ILE A 744
 None
None
ZN  A1157 (-3.3A)
KCX  A 718 ( 3.1A)
None
 1.11A 4rvdA-2qf7A:
3.4		 4rvdA-2qf7A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 THR A 882
VAL A 881
THR A 588
VAL A 591
GLU A 582
 None
 1.32A 4s0vA-2qf7A:
undetectable		 4s0vA-2qf7A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 ASP A1043
SER A1040
THR A 478
ALA A 481
ASN A 486
 None
 1.44A 4u15A-2qf7A:
undetectable		 4u15A-2qf7A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 5 ASP A 655
VAL A 636
ASP A 633
GLY A 953
 None
 1.20A 4xp6A-2qf7A:
undetectable		 4xp6A-2qf7A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_A_FOLA201_0
(FOLATE ECF
TRANSPORTER)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 LEU A 985
MET A 618
ALA A 643
PHE A 589
THR A 588
 None
 1.18A 4z7fA-2qf7A:
0.0		 4z7fA-2qf7A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 ASP A1043
SER A1040
THR A 478
ALA A 481
ASN A 486
 None
 1.42A 5dsgA-2qf7A:
1.8		 5dsgA-2qf7A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 ARG A 421
VAL A 405
LEU A 383
TYR A 373
ALA A 376
 None
 1.18A 5ikrA-2qf7A:
undetectable		 5ikrA-2qf7A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		3 / 3 GLN A 351
THR A 307
ASP A 384
 None
 0.92A 5k9dA-2qf7A:
7.4		 5k9dA-2qf7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 8 HIS A 747
HIS A 749
GLY A 842
SER A 553
 ZN  A1157 (-3.3A)
ZN  A1157 (-3.3A)
None
None
 0.97A 5m8rC-2qf7A:
undetectable		 5m8rC-2qf7A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 12 VAL A  30
ASP A  47
GLU A  48
ALA A  83
SER A  81
 None
 1.43A 5nd2B-2qf7A:
undetectable		 5nd2B-2qf7A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 7 THR A 561
LEU A 476
VAL A 483
GLU A1021
 None
 1.11A 5tudA-2qf7A:
undetectable		 5tudA-2qf7A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		3 / 3 HIS A 749
SER A 782
ARG A 548
 ZN  A1157 (-3.3A)
None
KCX  A 718 ( 3.6A)
 0.96A 5u63A-2qf7A:
2.7		 5u63A-2qf7A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		3 / 3 TYR A 452
ALA A 252
TYR A 254
 None
 0.70A 5uunB-2qf7A:
undetectable		 5uunB-2qf7A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		3 / 3 TYR A 452
ARG A 215
THR A 454
 None
None
AGS  A1162 (-3.5A)
 0.80A 5z84J-2qf7A:
undetectable		 5z84J-2qf7A:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		5 / 10 ILE A   3
TRP A  33
ILE A  14
ALA A  15
ALA A  31
 None
 1.47A 5zjiB-2qf7A:
undetectable		 5zjiB-2qf7A:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 6 GLN A 351
VAL A 311
LEU A 438
ARG A 424
 None
 1.11A 6brdB-2qf7A:
undetectable		 6brdB-2qf7A:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 7 ALA A 481
THR A 478
TYR A 479
VAL A 485
 None
 0.95A 6cduA-2qf7A:
undetectable
6cduE-2qf7A:
undetectable		 6cduA-2qf7A:
13.75
6cduE-2qf7A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 7 VAL A 485
ALA A 481
THR A 478
TYR A 479
 None
 0.92A 6cduH-2qf7A:
undetectable
6cduI-2qf7A:
undetectable		 6cduH-2qf7A:
13.75
6cduI-2qf7A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2qf7 PYRUVATE CARBOXYLASE
PROTEIN
(Rhizobium
etli) 		4 / 7 HIS A 745
THR A 543
ARG A 737
ASP A 768
 None
None
None
MG  A1158 (-3.5A)
 1.26A 6mn4E-2qf7A:
undetectable		 6mn4E-2qf7A:
12.45