SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 2qfe CALPAIN-7
(Homo
sapiens) 		4 / 5 PHE A 801
ILE A 781
ASN A 693
PHE A 782
 None
None
BR  A   5 ( 4.8A)
None
 1.35A 3octA-2qfeA:
undetectable		 3octA-2qfeA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2qfe CALPAIN-7
(Homo
sapiens) 		4 / 5 ARG A 759
ILE A 785
HIS A 711
GLY A 705
 None
 1.27A 4e7cC-2qfeA:
undetectable		 4e7cC-2qfeA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2qfe CALPAIN-7
(Homo
sapiens) 		4 / 6 LEU A 774
LEU A 727
GLU A 773
ILE A 729
 BR  A   9 ( 4.1A)
None
None
None
 0.94A 4ww7A-2qfeA:
undetectable		 4ww7A-2qfeA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 2qfe CALPAIN-7
(Homo
sapiens) 		3 / 3 ASN A 802
SER A 689
ARG A 691
 None
None
BR  A   4 (-3.2A)
 0.96A 5b2qA-2qfeA:
undetectable		 5b2qA-2qfeA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2qfe CALPAIN-7
(Homo
sapiens) 		4 / 7 GLN A 718
PHE A 719
PHE A 801
LEU A 799
 None
 0.89A 5b3sP-2qfeA:
undetectable		 5b3sP-2qfeA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2qfe CALPAIN-7
(Homo
sapiens) 		3 / 3 ASN A 706
ASP A 764
GLY A 763
 None
None
BR  A  11 ( 4.1A)
 0.64A 5fctB-2qfeA:
undetectable		 5fctB-2qfeA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 2qfe CALPAIN-7
(Homo
sapiens) 		5 / 12 HIS A 711
GLY A 705
ILE A 784
GLY A 740
SER A 787
 None
 1.07A 6c2mA-2qfeA:
undetectable		 6c2mA-2qfeA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 2qfe CALPAIN-7
(Homo
sapiens) 		5 / 12 HIS A 711
GLY A 705
ILE A 784
GLY A 740
SER A 787
 None
 1.09A 6c2mB-2qfeA:
undetectable		 6c2mB-2qfeA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2qfe CALPAIN-7
(Homo
sapiens) 		5 / 11 LEU A 731
ILE A 692
PHE A 741
ILE A 784
ILE A 729
 None
BR  A   8 ( 4.6A)
None
None
None
 1.08A 6ebzA-2qfeA:
undetectable		 6ebzA-2qfeA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2qfe CALPAIN-7
(Homo
sapiens) 		5 / 11 LEU A 731
ILE A 692
PHE A 741
ILE A 784
ILE A 729
 None
BR  A   8 ( 4.6A)
None
None
None
 1.07A 6ebzB-2qfeA:
undetectable		 6ebzB-2qfeA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2qfe CALPAIN-7
(Homo
sapiens) 		5 / 11 LEU A 731
ILE A 692
PHE A 741
ILE A 784
ILE A 729
 None
BR  A   8 ( 4.6A)
None
None
None
 1.09A 6ebzD-2qfeA:
undetectable		 6ebzD-2qfeA:
28.26