SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qfq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 10 LEU A  34
LEU A  31
LEU A 102
ALA A 105
LEU A 101
 None
 1.32A 1ie4A-2qfqA:
undetectable
1ie4C-2qfqA:
undetectable		 1ie4A-2qfqA:
15.99
1ie4C-2qfqA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 10 LEU A 102
ALA A 105
LEU A 101
LEU A  34
LEU A  31
 None
 1.34A 1ie4A-2qfqA:
undetectable
1ie4C-2qfqA:
undetectable		 1ie4A-2qfqA:
15.99
1ie4C-2qfqA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 11 ALA A  84
LEU A  92
LEU A 102
LEU A  60
LEU A  90
 None
 0.98A 2ceoA-2qfqA:
undetectable		 2ceoA-2qfqA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 LEU A 420
ALA A 252
ILE A 255
ILE A 403
LEU A   6
 None
 1.19A 2jn3A-2qfqA:
undetectable		 2jn3A-2qfqA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 11 LEU A  18
GLY A 264
ILE A 265
ILE A 294
LEU A 250
 None
 0.96A 2kawA-2qfqA:
undetectable		 2kawA-2qfqA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 HIS A 385
LYS A 411
SER A  25
ASP A 313
 FMT  A 601 (-4.3A)
FMT  A 602 (-2.8A)
None
S3P  A 701 ( 2.8A)
 1.07A 2obvA-2qfqA:
undetectable		 2obvA-2qfqA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 HIS A 385
LYS A 411
SER A  25
ASP A 313
 FMT  A 601 (-4.3A)
FMT  A 602 (-2.8A)
None
S3P  A 701 ( 2.8A)
 1.12A 2p02A-2qfqA:
undetectable		 2p02A-2qfqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		3 / 3 ASP A  49
ASN A  26
THR A 174
 FMT  A 602 ( 4.6A)
None
S3P  A 701 ( 4.8A)
 0.69A 2q63B-2qfqA:
undetectable		 2q63B-2qfqA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 10 ALA A  84
LEU A  92
LEU A 102
LEU A  60
LEU A  90
 None
 1.01A 2riwA-2qfqA:
undetectable
2riwB-2qfqA:
undetectable		 2riwA-2qfqA:
22.20
2riwB-2qfqA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 10 ALA A  84
LEU A  92
LEU A 102
LEU A  60
LEU A  90
 None
 0.98A 2xn6A-2qfqA:
undetectable
2xn6B-2qfqA:
undetectable		 2xn6A-2qfqA:
23.06
2xn6B-2qfqA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 10 ALA A  84
LEU A  92
LEU A 102
LEU A  60
LEU A  90
 None
 0.93A 2xn7A-2qfqA:
undetectable
2xn7B-2qfqA:
undetectable		 2xn7A-2qfqA:
22.84
2xn7B-2qfqA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 GLN A 171
ARG A 100
ASP A 313
SER A 244
 S3P  A 701 (-4.0A)
None
S3P  A 701 ( 2.8A)
None
 1.12A 2xytH-2qfqA:
undetectable		 2xytH-2qfqA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 6 LEU A 280
ILE A 255
ALA A 252
THR A 317
 None
 1.05A 3mdrA-2qfqA:
undetectable		 3mdrA-2qfqA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 6 ALA A 277
ILE A 294
LEU A 250
ALA A 314
 None
 0.91A 3r9sA-2qfqA:
undetectable		 3r9sA-2qfqA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 6 GLU A 378
PRO A 406
LYS A   1
GLU A   2
 None
 1.47A 4a7tA-2qfqA:
undetectable		 4a7tA-2qfqA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 6 GLU A 378
PRO A 406
LYS A   1
GLU A   2
 None
 1.48A 4a7tF-2qfqA:
undetectable		 4a7tF-2qfqA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 6 GLU A 378
PRO A 406
LYS A   1
GLU A   2
 None
 1.45A 4a7uA-2qfqA:
undetectable		 4a7uA-2qfqA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 5 HIS A 128
SER A 167
SER A 169
VAL A 196
 None
None
S3P  A 701 (-2.6A)
None
 1.33A 4a99D-2qfqA:
undetectable		 4a99D-2qfqA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 HIS A 385
LYS A 411
SER A  25
ASP A 313
 FMT  A 601 (-4.3A)
FMT  A 602 (-2.8A)
None
S3P  A 701 ( 2.8A)
 1.09A 4kttA-2qfqA:
undetectable		 4kttA-2qfqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 HIS A 385
LYS A 411
SER A  25
ASP A 313
 FMT  A 601 (-4.3A)
FMT  A 602 (-2.8A)
None
S3P  A 701 ( 2.8A)
 1.06A 4kttC-2qfqA:
undetectable		 4kttC-2qfqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 HIS A 385
LYS A 411
SER A  25
ASP A 313
 FMT  A 601 (-4.3A)
FMT  A 602 (-2.8A)
None
S3P  A 701 ( 2.8A)
 1.05A 4ndnA-2qfqA:
undetectable		 4ndnA-2qfqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 7 HIS A 385
LYS A 411
SER A  25
ASP A 313
 FMT  A 601 (-4.3A)
FMT  A 602 (-2.8A)
None
S3P  A 701 ( 2.8A)
 1.04A 4ndnC-2qfqA:
undetectable		 4ndnC-2qfqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 7 HIS A 385
LYS A 411
SER A  25
ASP A 313
 FMT  A 601 (-4.3A)
FMT  A 602 (-2.8A)
None
S3P  A 701 ( 2.8A)
 1.13A 4odjA-2qfqA:
undetectable		 4odjA-2qfqA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		3 / 3 GLY A  80
PRO A  81
ALA A 105
 None
 0.30A 4qn9B-2qfqA:
undetectable		 4qn9B-2qfqA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 ALA A 319
ILE A 318
LEU A 301
MET A 283
GLY A 284
 None
 1.16A 4r38D-2qfqA:
undetectable		 4r38D-2qfqA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 MET A 387
PHE A 391
ALA A 322
LEU A 323
 None
 1.00A 4rkuA-2qfqA:
undetectable
4rkuJ-2qfqA:
undetectable		 4rkuA-2qfqA:
20.95
4rkuJ-2qfqA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 9 PRO A 181
GLY A 159
ILE A 215
MET A 208
LEU A 177
 None
 1.24A 4x3mB-2qfqA:
undetectable		 4x3mB-2qfqA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		3 / 3 ASP A  48
ARG A 344
ARG A 124
 None
FMT  A 601 (-2.6A)
FMT  A 602 (-3.1A)
 0.86A 4x5iA-2qfqA:
undetectable		 4x5iA-2qfqA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 7 MET A 387
PHE A 391
ALA A 322
LEU A 323
 None
 1.06A 4xk8A-2qfqA:
undetectable		 4xk8A-2qfqA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 9 SER A  25
LEU A  54
LEU A  57
ILE A  75
 None
 0.95A 4xtaA-2qfqA:
undetectable		 4xtaA-2qfqA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 SER A  25
LEU A  54
LEU A  57
ILE A  75
 None
 0.98A 4xtaB-2qfqA:
undetectable		 4xtaB-2qfqA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 HIS A 385
LYS A 411
SER A  25
ASP A 313
 FMT  A 601 (-4.3A)
FMT  A 602 (-2.8A)
None
S3P  A 701 ( 2.8A)
 1.14A 5a1iA-2qfqA:
undetectable		 5a1iA-2qfqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 7 HIS A 385
LYS A 411
SER A  25
ASP A 313
 FMT  A 601 (-4.3A)
FMT  A 602 (-2.8A)
None
S3P  A 701 ( 2.8A)
 1.14A 5a1iA-2qfqA:
undetectable		 5a1iA-2qfqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		3 / 3 ASP A  48
ARG A 344
ARG A 124
 None
FMT  A 601 (-2.6A)
FMT  A 602 (-3.1A)
 0.95A 5eajB-2qfqA:
undetectable		 5eajB-2qfqA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 LEU A  44
SER A  47
VAL A  50
SER A 269
GLY A 272
 None
 1.18A 5f9zB-2qfqA:
undetectable		 5f9zB-2qfqA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 ILE A  75
GLU A  74
ARG A  72
ASN A  55
LEU A  44
 None
FMT  A 605 ( 4.8A)
FMT  A 605 (-4.0A)
None
None
 1.39A 5fhzD-2qfqA:
undetectable		 5fhzD-2qfqA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 9 SER A 169
GLY A 166
ALA A 132
VAL A 164
ILE A 191
 S3P  A 701 (-2.6A)
None
None
None
None
 1.49A 5i3cA-2qfqA:
undetectable		 5i3cA-2qfqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		6 / 11 LEU A 108
GLY A 156
LEU A 182
THR A 158
GLU A 185
ALA A 183
 None
 1.50A 5o96G-2qfqA:
undetectable		 5o96G-2qfqA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 PHE A 276
ALA A 277
ALA A 426
ALA A  10
THR A 286
 None
 1.23A 5tl8A-2qfqA:
undetectable		 5tl8A-2qfqA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 LEU A 345
THR A 320
ILE A 368
ARG A 353
THR A 342
 None
 1.25A 5z6fA-2qfqA:
undetectable		 5z6fA-2qfqA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 ILE A  75
VAL A  62
LEU A 102
ALA A 105
LEU A  82
 None
 1.13A 6ajiA-2qfqA:
undetectable		 6ajiA-2qfqA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 6 ILE A 334
MET A 308
ASN A 309
ASP A 307
 None
 1.24A 6dhbA-2qfqA:
undetectable		 6dhbA-2qfqA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 HIS A 385
LYS A 411
SER A  25
ASP A 313
 FMT  A 601 (-4.3A)
FMT  A 602 (-2.8A)
None
S3P  A 701 ( 2.8A)
 1.07A 6fbnB-2qfqA:
undetectable		 6fbnB-2qfqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 HIS A 385
LYS A 411
SER A  25
ASP A 313
 FMT  A 601 (-4.3A)
FMT  A 602 (-2.8A)
None
S3P  A 701 ( 2.8A)
 1.14A 6fboA-2qfqA:
undetectable		 6fboA-2qfqA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 HIS A 385
LYS A 411
SER A  25
ASP A 313
 FMT  A 601 (-4.3A)
FMT  A 602 (-2.8A)
None
S3P  A 701 ( 2.8A)
 1.09A 6fcbA-2qfqA:
undetectable		 6fcbA-2qfqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 HIS A 385
LYS A 411
SER A  25
ASP A 313
 FMT  A 601 (-4.3A)
FMT  A 602 (-2.8A)
None
S3P  A 701 ( 2.8A)
 1.15A 6fcdA-2qfqA:
undetectable		 6fcdA-2qfqA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 6 MET A  53
GLY A  96
ALA A 103
LEU A 115
 None
FMT  A 602 (-3.4A)
None
None
 1.08A 6fosA-2qfqA:
undetectable		 6fosA-2qfqA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 7 HIS A 385
LYS A 411
SER A  25
ASP A 313
 FMT  A 601 (-4.3A)
FMT  A 602 (-2.8A)
None
S3P  A 701 ( 2.8A)
 1.14A 6g6rA-2qfqA:
undetectable		 6g6rA-2qfqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Escherichia
coli) 		4 / 8 ARG A  51
GLY A  93
LEU A  92
ALA A  98
 None
 0.80A 6mdqA-2qfqA:
undetectable		 6mdqA-2qfqA:
12.75