SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 8 THR A 129
GLY A 156
PHE A 130
GLY A 390
 None
 0.72A 1d0vA-2qfrA:
undetectable		 1d0vA-2qfrA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		3 / 3 ARG A 222
THR A  48
VAL A  47
 None
 0.93A 1hxbA-2qfrA:
undetectable		 1hxbA-2qfrA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 8 THR A 129
GLY A 156
PHE A 130
GLY A 390
 None
 0.70A 1jhaA-2qfrA:
undetectable		 1jhaA-2qfrA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 8 THR A 129
GLY A 156
PHE A 130
GLY A 390
 None
 0.75A 1jhqA-2qfrA:
undetectable		 1jhqA-2qfrA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 8 THR A 129
GLY A 156
PHE A 130
GLY A 390
 None
 0.74A 1jhvA-2qfrA:
undetectable		 1jhvA-2qfrA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		5 / 12 HIS A 325
ALA A 362
GLY A 134
ILE A 204
ASP A 169
 FE  A 433 ( 3.5A)
None
None
None
None
 1.13A 1kxhA-2qfrA:
undetectable		 1kxhA-2qfrA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 6 TYR A 167
GLU A 299
ILE A 368
GLY A 363
 FE  A 433 (-4.5A)
None
None
None
 1.01A 1maaB-2qfrA:
undetectable
1maaD-2qfrA:
undetectable		 1maaB-2qfrA:
20.17
1maaD-2qfrA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		5 / 12 TYR A 379
VAL A 324
ASP A 369
ALA A 381
SER A 330
 None
 1.35A 1nbhC-2qfrA:
undetectable		 1nbhC-2qfrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		3 / 3 TYR A 290
ARG A 423
GLN A 351
 None
 1.00A 1tw4A-2qfrA:
undetectable		 1tw4A-2qfrA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		5 / 12 ALA A 245
ILE A 247
ASP A 361
ILE A 359
TYR A 327
 None
 1.08A 1x1aA-2qfrA:
undetectable		 1x1aA-2qfrA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		5 / 12 ILE A 133
GLY A 134
GLY A 322
GLY A 390
ALA A 362
 None
 1.01A 2fk8A-2qfrA:
undetectable		 2fk8A-2qfrA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_2
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 4 TRP A 425
LEU A 124
VAL A 273
LYS A 272
 None
 1.38A 2hw2A-2qfrA:
0.0		 2hw2A-2qfrA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		3 / 3 ARG A 222
THR A  48
VAL A  47
 None
 0.92A 2q64A-2qfrA:
undetectable		 2q64A-2qfrA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		3 / 3 ARG A 222
THR A  48
VAL A  47
 None
 0.81A 2qakA-2qfrA:
undetectable		 2qakA-2qfrA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 6 LEU A 160
PHE A 320
ILE A 282
PHE A 307
 None
 0.93A 3ko0B-2qfrA:
undetectable		 3ko0B-2qfrA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 6 LEU A 160
PHE A 320
ILE A 282
PHE A 307
 None
 0.98A 3ko0S-2qfrA:
undetectable		 3ko0S-2qfrA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 7 THR A 186
TRP A 182
HIS A  31
TYR A 223
 None
 1.47A 4a3uA-2qfrA:
undetectable		 4a3uA-2qfrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 7 THR A 186
TRP A 182
HIS A  31
TYR A 223
 None
 1.47A 4a3uB-2qfrA:
undetectable		 4a3uB-2qfrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		5 / 12 LEU A 284
GLY A 134
GLY A 363
LEU A 160
GLY A 131
 None
 1.15A 4blvA-2qfrA:
undetectable		 4blvA-2qfrA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		5 / 12 ASP A 361
HIS A 389
GLY A 134
GLY A 322
LEU A 146
 None
 1.16A 4blvB-2qfrA:
undetectable		 4blvB-2qfrA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		3 / 3 HIS A 295
GLU A 299
ASN A 201
 SO4  A 435 (-4.1A)
None
ZN  A 434 ( 2.7A)
 1.04A 4bupB-2qfrA:
undetectable		 4bupB-2qfrA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		3 / 3 GLY A  72
SER A  55
TRP A  46
 None
 0.92A 4e7cD-2qfrA:
undetectable		 4e7cD-2qfrA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 8 ILE A 247
LEU A 132
GLY A 131
PHE A 130
 None
 0.81A 4iqqD-2qfrA:
undetectable		 4iqqD-2qfrA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 7 LEU A 160
VAL A 159
PRO A 194
TYR A 238
 None
 0.79A 4lb2A-2qfrA:
undetectable		 4lb2A-2qfrA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		5 / 12 HIS A 296
ASP A 369
ASP A 135
ASN A 201
HIS A 286
 SO4  A 435 (-3.9A)
None
FE  A 433 ( 2.9A)
ZN  A 434 ( 2.7A)
ZN  A 434 (-3.2A)
 1.34A 4pgfA-2qfrA:
undetectable		 4pgfA-2qfrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 7 VAL A 283
PHE A 320
ASN A 335
PHE A 311
 None
 0.96A 5hieC-2qfrA:
undetectable		 5hieC-2qfrA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 7 PHE A 161
GLY A 137
GLY A 363
HIS A 325
 None
None
None
FE  A 433 ( 3.5A)
 0.95A 5n9xA-2qfrA:
undetectable		 5n9xA-2qfrA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 4 ASP A 164
HIS A 286
HIS A 323
HIS A 202
 ZN  A 434 ( 2.8A)
ZN  A 434 (-3.2A)
ZN  A 434 ( 3.1A)
SO4  A 435 (-4.2A)
 1.46A 5ncdD-2qfrA:
undetectable		 5ncdD-2qfrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 4 ASP A 369
HIS A 295
HIS A 296
HIS A 325
 None
SO4  A 435 (-4.1A)
SO4  A 435 (-3.9A)
FE  A 433 ( 3.5A)
 1.42A 5ncdD-2qfrA:
undetectable		 5ncdD-2qfrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 6 HIS A 202
HIS A 295
HIS A 296
HIS A 325
 SO4  A 435 (-4.2A)
SO4  A 435 (-4.1A)
SO4  A 435 (-3.9A)
FE  A 433 ( 3.5A)
 0.91A 5nelB-2qfrA:
undetectable
5nelC-2qfrA:
undetectable		 5nelB-2qfrA:
19.39
5nelC-2qfrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 7 ASN A 201
HIS A 202
ASP A 135
GLY A 366
 ZN  A 434 ( 2.7A)
SO4  A 435 (-4.2A)
FE  A 433 ( 2.9A)
None
 1.00A 5x7pA-2qfrA:
undetectable		 5x7pA-2qfrA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		5 / 12 TYR A 167
GLY A 134
GLY A 137
LEU A 132
ASP A 135
 FE  A 433 (-4.5A)
None
None
None
FE  A 433 ( 2.9A)
 1.34A 5yn6A-2qfrA:
undetectable		 5yn6A-2qfrA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		5 / 12 TYR A 167
GLY A 134
GLY A 137
LEU A 132
ASP A 164
 FE  A 433 (-4.5A)
None
None
None
ZN  A 434 ( 2.8A)
 1.34A 5yn6A-2qfrA:
undetectable		 5yn6A-2qfrA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		5 / 12 TYR A 167
GLY A 134
GLY A 137
LEU A 132
ASP A 135
 FE  A 433 (-4.5A)
None
None
None
FE  A 433 ( 2.9A)
 1.33A 5ynmA-2qfrA:
undetectable		 5ynmA-2qfrA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 4 VAL A 162
GLY A 134
ASP A 135
ASP A 361
 None
None
FE  A 433 ( 2.9A)
None
 0.98A 6cjkC-2qfrA:
5.1		 6cjkC-2qfrA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		5 / 10 GLY A 134
ILE A 359
ALA A 362
HIS A 389
GLY A 390
 None
 0.93A 6e5zA-2qfrA:
undetectable		 6e5zA-2qfrA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		5 / 12 ARG A 112
VAL A 105
ILE A  44
VAL A 190
ILE A  32
 None
 1.49A 6gsdA-2qfrA:
2.5		 6gsdA-2qfrA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2qfr PURPLE ACID
PHOSPHATASE
(Phaseolus
vulgaris) 		4 / 7 TRP A 182
HIS A 174
GLU A 203
ASP A 164
 None
None
None
ZN  A 434 ( 2.8A)
 1.43A 6mn4F-2qfrA:
undetectable		 6mn4F-2qfrA:
21.12