SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qga'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2qga ADENYLOSUCCINATE
LYASE
(Plasmodium
vivax) 		5 / 10 ILE B  35
ALA B 127
ILE B  74
ILE B  34
THR B 130
 None
 1.24A 1rb3A-2qgaB:
undetectable		 1rb3A-2qgaB:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2qga ADENYLOSUCCINATE
LYASE
(Plasmodium
vivax) 		4 / 6 LEU B 282
TYR B 276
ILE B 273
GLY B 178
 None
 0.86A 2du8A-2qgaB:
undetectable		 2du8A-2qgaB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 2qga ADENYLOSUCCINATE
LYASE
(Plasmodium
vivax) 		3 / 3 LYS B 152
ARG B 457
VAL B 455
 None
 0.92A 2r2vC-2qgaB:
undetectable
2r2vD-2qgaB:
undetectable		 2r2vC-2qgaB:
6.47
2r2vD-2qgaB:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2qga ADENYLOSUCCINATE
LYASE
(Plasmodium
vivax) 		3 / 3 TYR B 350
LEU B 362
LYS B 360
 None
 0.74A 3sueD-2qgaB:
undetectable		 3sueD-2qgaB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 2qga ADENYLOSUCCINATE
LYASE
(Plasmodium
vivax) 		5 / 11 LEU B 282
ILE B 367
SER B 174
LEU B 154
LEU B 269
 None
 1.15A 4dm8A-2qgaB:
undetectable		 4dm8A-2qgaB:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2qga ADENYLOSUCCINATE
LYASE
(Plasmodium
vivax) 		4 / 8 SER B 329
ASP B 334
VAL B 340
THR B 339
 None
None
None
AMP  B 908 (-4.6A)
 1.11A 4lnwA-2qgaB:
1.7		 4lnwA-2qgaB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 2qga ADENYLOSUCCINATE
LYASE
(Plasmodium
vivax) 		3 / 3 PHE B 177
THR B 265
LEU B 362
 None
 0.47A 4qztA-2qgaB:
undetectable		 4qztA-2qgaB:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2qga ADENYLOSUCCINATE
LYASE
(Plasmodium
vivax) 		4 / 6 ILE B 421
GLN B 418
ILE B 412
ASP B 413
 None
 1.08A 4w5qA-2qgaB:
undetectable		 4w5qA-2qgaB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2qga ADENYLOSUCCINATE
LYASE
(Plasmodium
vivax) 		4 / 6 ILE B 421
GLN B 418
ILE B 416
ASP B 413
 None
 1.19A 4z4cA-2qgaB:
undetectable		 4z4cA-2qgaB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 2qga ADENYLOSUCCINATE
LYASE
(Plasmodium
vivax) 		5 / 12 ALA B 202
TYR B 239
LEU B 117
PHE B  50
PHE B 211
 None
 1.14A 5fsaA-2qgaB:
1.6		 5fsaA-2qgaB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2qga ADENYLOSUCCINATE
LYASE
(Plasmodium
vivax) 		5 / 12 ILE B  74
ILE B  69
VAL B  77
GLU B  97
ASN B 101
 None
 1.18A 5lg3J-2qgaB:
undetectable		 5lg3J-2qgaB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 2qga ADENYLOSUCCINATE
LYASE
(Plasmodium
vivax) 		5 / 12 LEU B 259
ASN B 263
SER B 357
LEU B 359
LEU B 352
 None
 1.17A 5mwyA-2qgaB:
undetectable		 5mwyA-2qgaB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 2qga ADENYLOSUCCINATE
LYASE
(Plasmodium
vivax) 		3 / 3 GLU B 145
HIS B 189
VAL B 192
 None
 0.89A 5trqB-2qgaB:
undetectable		 5trqB-2qgaB:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2qga ADENYLOSUCCINATE
LYASE
(Plasmodium
vivax) 		3 / 3 ARG B 342
PHE B 319
LEU B 326
 AMP  B 908 (-3.7A)
None
None
 0.84A 5veuA-2qgaB:
undetectable		 5veuA-2qgaB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 2qga ADENYLOSUCCINATE
LYASE
(Plasmodium
vivax) 		4 / 5 ASN B 183
TYR B 276
LEU B 372
SER B 165
 None
 1.27A 6a7pA-2qgaB:
2.9		 6a7pA-2qgaB:
22.48