SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qgm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 ILE A 410
ASN A 307
GLY A  85
PHE A 348
TYR A 140
 None
 1.25A 1hvyA-2qgmA:
undetectable		 1hvyA-2qgmA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 ILE A 410
ASN A 307
GLY A  85
PHE A 348
TYR A 140
 None
 1.23A 1hvyB-2qgmA:
undetectable		 1hvyB-2qgmA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 11 ILE A 410
ASN A 307
GLY A  85
PHE A 348
TYR A 140
 None
 1.32A 1hvyC-2qgmA:
undetectable		 1hvyC-2qgmA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 11 ILE A 410
ASN A 307
GLY A  85
PHE A 348
TYR A 140
 None
 1.13A 1ju6A-2qgmA:
undetectable		 1ju6A-2qgmA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 10 ILE A 410
ASN A 307
GLY A  85
PHE A 348
TYR A 140
 None
 1.14A 1ju6C-2qgmA:
undetectable		 1ju6C-2qgmA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 10 ILE A 410
ASN A 307
GLY A  85
PHE A 348
TYR A 140
 None
 1.21A 1jujA-2qgmA:
undetectable		 1jujA-2qgmA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 10 ILE A 410
ASN A 307
GLY A  85
PHE A 348
TYR A 140
 None
 1.21A 1jujB-2qgmA:
undetectable		 1jujB-2qgmA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 10 ILE A 410
ASN A 307
GLY A  85
PHE A 348
TYR A 140
 None
 1.21A 1jujC-2qgmA:
undetectable		 1jujC-2qgmA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 10 ILE A 410
ASN A 307
GLY A  85
PHE A 348
TYR A 140
 None
 1.21A 1jujD-2qgmA:
undetectable		 1jujD-2qgmA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 GLU A  81
GLY A  78
ALA A 110
LEU A 332
PHE A 430
 None
 1.31A 1nw3A-2qgmA:
undetectable		 1nw3A-2qgmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 GLY A 116
GLY A 118
GLY A 169
GLN A 177
PHE A 180
 None
 1.17A 1wg8A-2qgmA:
undetectable		 1wg8A-2qgmA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 ILE A 410
ASN A 307
GLY A  85
PHE A 348
TYR A 140
 None
 1.23A 3nrrA-2qgmA:
undetectable		 3nrrA-2qgmA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 ILE A 410
ASN A 307
GLY A  85
PHE A 348
TYR A 140
 None
 1.23A 3nrrB-2qgmA:
2.3		 3nrrB-2qgmA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		3 / 3 TYR A 124
GLU A 113
TYR A 140
 None
 0.84A 3ug8A-2qgmA:
undetectable		 3ug8A-2qgmA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 LEU A 319
TYR A 320
GLY A 411
ILE A 308
ILE A 414
 None
 1.03A 3uj6A-2qgmA:
undetectable		 3uj6A-2qgmA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 ILE A 436
LEU A  52
GLY A 340
ASN A 307
LEU A 387
 None
 0.98A 3uq6B-2qgmA:
undetectable		 3uq6B-2qgmA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		4 / 7 THR A 439
HIS A 435
ASN A 375
LEU A 408
 None
 1.34A 4awuA-2qgmA:
undetectable		 4awuA-2qgmA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		6 / 12 GLY A 325
GLY A 313
ILE A 310
ALA A 324
HIS A 309
LEU A 170
 None
 1.28A 4iv8B-2qgmA:
undetectable		 4iv8B-2qgmA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 HIS A 435
LEU A 426
PHE A 386
ILE A  45
LEU A 407
 None
 1.47A 4r88A-2qgmA:
undetectable		 4r88A-2qgmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 HIS A 435
LEU A 426
PHE A 386
ILE A  45
LEU A 407
 None
 1.47A 4r88B-2qgmA:
undetectable		 4r88B-2qgmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 HIS A 435
LEU A 426
PHE A 386
ILE A  45
LEU A 407
 None
 1.48A 4r88C-2qgmA:
undetectable		 4r88C-2qgmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 HIS A 435
LEU A 426
PHE A 386
ILE A  45
LEU A 407
 None
 1.49A 4r88D-2qgmA:
undetectable		 4r88D-2qgmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 HIS A 435
LEU A 426
PHE A 386
ILE A  45
LEU A 407
 None
 1.49A 4r88E-2qgmA:
undetectable		 4r88E-2qgmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 HIS A 435
LEU A 426
PHE A 386
ILE A  45
LEU A 407
 None
 1.47A 4r88F-2qgmA:
undetectable		 4r88F-2qgmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 LEU A 426
LEU A  79
MET A 302
ILE A  71
LEU A  67
 None
 1.10A 5ienA-2qgmA:
undetectable		 5ienA-2qgmA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		5 / 12 LEU A 426
LEU A  79
MET A 302
ILE A  71
LEU A  67
 None
 1.15A 5ienB-2qgmA:
undetectable		 5ienB-2qgmA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		3 / 3 THR A 439
SER A  86
ASP A 365
 None
 0.84A 5kvaA-2qgmA:
undetectable		 5kvaA-2qgmA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		4 / 6 TYR A 322
VAL A 323
ILE A 314
GLU A 317
 None
 1.04A 5z3jA-2qgmA:
undetectable		 5z3jA-2qgmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		3 / 3 LEU A 281
GLN A 284
LYS A 227
 None
 0.81A 6exiB-2qgmA:
undetectable		 6exiB-2qgmA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN
(Bacillus
cereus) 		3 / 3 LEU A 281
GLN A 284
LYS A 227
 None
 0.84A 6exiA-2qgmA:
undetectable		 6exiA-2qgmA:
13.54